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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 5
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Original Article

Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes

B. J. Blaauboer Institute of Veterinary Pharmacology, Pharmacy and Toxicology, University of Utrecht, Biltstraat 172, 3572 BP, Utrecht, The Netherlands
&
C. W. M. Van Holsteijn Institute of Veterinary Pharmacology, Pharmacy and Toxicology, University of Utrecht, Biltstraat 172, 3572 BP, Utrecht, The Netherlands
Pages 295-302 | Received 01 Dec 1982, Published online: 30 Sep 2009

Citations (13)

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X.-Q. Wang, W. Seinen & W. De Wolf. (1994) Biotransformation of monochloroanilines in guppy, Poecilia reticulata. Xenobiotica 24:1, pages 59-69.
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J. M. Dady, S. P. Bradbury, A. D. Hoffman, M. M. Voit & D. L. Olson. (1991) Hepatic microsomal N-hydroxylation of aniline and 4-chloroaniline by rainbow trout (Onchorhyncus mykiss). Xenobiotica 21:12, pages 1605-1620.
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C. T. A. Evelo, J. F. M. Versteegh & B. J. Blaauboer. (1984) Kinetics of the formation and secretion of the aniline metabolite 4-aminophenol and its conjugates by isolated rat hepatocytes. Xenobiotica 14:5, pages 409-416.
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Articles from other publishers (10)

Takashi Yamada, Tomoko Kawamura, Shinji Tsujii, Minoru Miura, Hideo Ohata, Naruo Katsutani, Mariko Matsumoto & Akihiko Hirose. (2022) Formation and evaluation of mechanism-based chemical categories for regulatory read-across assessment of repeated-dose toxicity: A case of hemolytic anemia. Regulatory Toxicology and Pharmacology 136, pages 105275.
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Takashi Yamada, Masayuki Kurimoto, Akihiko Hirose, Chihae Yang & James F. Rathman. (2021) Development of a New Threshold of Toxicological Concern Database of Non-cancer Toxicity Endpoints for Industrial Chemicals. Frontiers in Toxicology 3.
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Sean C Gay, Arthur G Roberts & James R Halpert. (2010) Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR. Future Medicinal Chemistry 2:9, pages 1451-1468.
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Hongli Li, Haifang Wang, Hongfang Sun, Yuanfang Liu, Kexin Liu & Shixiang Peng. (2003) Binding of nitrobenzene to hepatic DNA and hemoglobin at low doses in mice. Toxicology Letters 139:1, pages 25-32.
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Yasuhiro Ohkuma, Yusuke Hiraku, Shinji Oikawa, Naruto Yamashita, Mariko Murata & Shosuke Kawanishi. (1999) Distinct Mechanisms of Oxidative DNA Damage by Two Metabolites of Carcinogenic o-Toluidine. Archives of Biochemistry and Biophysics 372:1, pages 97-106.
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Yasuhiro Ohkuma & Shosuke Kawanishi. (1999) Oxidative DNA Damage by a Metabolite of Carcinogenic and Reproductive Toxic Nitrobenzene in the Presence of NADH and Cu(II). Biochemical and Biophysical Research Communications 257:2, pages 555-560.
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Frank N.A.M. van Pelt, Wim C. Mennes, Ine G.A.M. Hassing & Bas J. Blaauboer. (1989) Application of high-performance liquid chromatographic analysis of scoparone and its metabolites in the study of cytochrome P450 differentiation in vitro. Journal of Chromatography B: Biomedical Sciences and Applications 487, pages 489-495.
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M. Ascherl, P. Eyer & H. Kampffmeyer. (1985) Formation and disposition of nitrosochloramphenicol in rat liver. Biochemical Pharmacology 34:20, pages 3755-3763.
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M. R. O’Donovan. 1985. Comparative Genetic Toxicology. Comparative Genetic Toxicology 281 289 .
James L. Wilmer, Gregory L. Erexson & Andrew D. Kligerman. 1984. Sister Chromatid Exchanges. Sister Chromatid Exchanges 561 567 .

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