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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 7
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Original Article

Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine

A. H. Beckett Department of Pharmacy, Chelsea College, (University of London), Manresa Road, London, SW3 6LX, UK; Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG
,
A. J. Hutt Department of Pharmacy, Chelsea College, (University of London), Manresa Road, London, SW3 6LX, UK; Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG
&
G. E. Navas Department of Pharmacy, Chelsea College, (University of London), Manresa Road, London, SW3 6LX, UK; Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG
Pages 391-405 | Received 19 Jan 1983, Published online: 30 Sep 2009

Citations (6)

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K. Strandgården & P. O. Gunnarsson. (1994) Metabolism of lofepramine and imipramine in liver microsomes from rat and man. Xenobiotica 24:8, pages 703-711.
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A. H. Beckett, G. E. Navas & A. J. Hutt. (1988) Metabolism of chlorpromazine and promazine in vitro: Isolation and characterization of N-oxidation products. Xenobiotica 18:1, pages 61-74.
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F. S. Abbott, J. G. Slatter, R. Burton & Gun Il Kang. (1985) Methadone metabolism in the rat in vivo: identification of a novel formamide metabolite. Xenobiotica 15:2, pages 129-140.
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Articles from other publishers (3)

Kelsey L. Hanson, Brooke M. VandenBrink, Kantipudi N. Babu, Kyle E. Allen, Wendel L. Nelson & Kent L. Kunze. (2010) Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, ( S )-Fluoxetine, and N- Desmethyldiltiazem . Drug Metabolism and Disposition 38:6, pages 963-972.
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Ellen W. Baxter & Allen B. Reitz. 2004. Organic Reactions. Organic Reactions 1 714 .
C. Bensoussan, M. Delaforge & D. Mansuy. (1995) Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. Biochemical Pharmacology 49:5, pages 591-602.
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