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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 8
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Original Article

p-Cymene metabolism in rats and guinea-pigs

A. Walde Department of Pharmacology, School of Medicine, University of Bergen, MFH-Bygget, 5016 Haukeland, Sykehus, Bergen, Norway
,
B. Ve Department of Pharmacology, School of Medicine, University of Bergen, MFH-Bygget, 5016 Haukeland, Sykehus, Bergen, Norway
,
R. R. Scheline Department of Pharmacology, School of Medicine, University of Bergen, MFH-Bygget, 5016 Haukeland, Sykehus, Bergen, Norway
&
P. Monge National Institute of Forensic Toxicology, Sognsvannsveien 28, Oslo, 3, Norway
Pages 503-512 | Received 19 Apr 1983, Published online: 30 Sep 2009

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Yasushi Yamazoe, Kazumi Ito & Kouichi Yoshinari. (2011) Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order. Drug Metabolism Reviews 43:4, pages 409-439.
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R. J. W. Meesters, M. Duisken & J. Hollender. (2009) Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?. Xenobiotica 39:9, pages 663-671.
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G. J. Pass, S. McLean, I. Stupans & N. W. Davies. (2002) Microsomal metabolism and enyzme kinetics of the terpene p-cymene in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus) and rat. Xenobiotica 32:5, pages 383-397.
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G. J. Pass, S. McLean, I. Stupans & N. Davies. (2001) Microsomal metabolism of the terpene 1,8-cineole in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus), rat and human. Xenobiotica 31:4, pages 205-221.
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T. Ishida & T. Matsumoto. (1992) Enantioselective metabolism of cumene. Xenobiotica 22:11, pages 1291-1298.
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T. Ishida, M. Toyota & Y. Asakawa. (1989) Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (−)-perillaldehyde, (−)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits. Xenobiotica 19:8, pages 843-855.
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Y. Asakawa, M. Toyota & T. Ishida. (1988) Biotransformation of 1,4-Cineole, a Monoterpene Ether. Xenobiotica 18:10, pages 1129-1134.
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O. B. Samuelsen, J. Brenna, E. Solheim & R. R. Scheline. (1986) Metabolism of the cinnamon constituent o-methoxycinnamaldehyde in the rat. Xenobiotica 16:9, pages 845-852.
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Articles from other publishers (22)

Rick Wilhiam de Camargo, Marina Goulart da Silva, Guilherme Cabreira Daros, Fabiana Durante de Medeiros, Naiana da Rosa, Caroline Liana Menschhein Medeiros, Eduardo de Medeiros Peretti, Juliete Palandi, Franciane Bobinski, Jucélia Jeremias Fortunato & Rafael Mariano de Bitencourt. (2021) Effects of Chronic Administration of P-Cymene in an Animal Model of LPS-Induced Autism. Planta Medica International Open 8:03, pages e104-e113.
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Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
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Ellen Games, Marina Guerreiro, Fernanda Santana, Nathalia Pinheiro, Emerson de Oliveira, Fernanda Lopes, Clarice Olivo, Iolanda Tibério, Mílton Martins, João Lago & Carla Prado. (2016) Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema. Molecules 21:10, pages 1390.
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. (2015) Scientific Opinion on Flavouring Group Evaluation 18, Revision 3 (FGE.18Rev3): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 13:5.
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. 2014. Essential Oil Safety. Essential Oil Safety 677 755 .
Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety 483 647 .
D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat & I.G. Sipes. (2012) A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients. Food and Chemical Toxicology 50, pages S52-S99.
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J. Scognamiglio, L. Jones, C.S. Letizia & A.M. Api. (2012) Fragrance material review on p-α,α-trimethylbenzyl alcohol. Food and Chemical Toxicology 50, pages S113-S116.
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T.B. Adams, C. Lucas Gavin, M.M. McGowen, W.J. Waddell, S.M. Cohen, V.J. Feron, L.J. Marnett, I.C. Munro, P.S. Portoghese, I.M.C.M. Rietjens & R.L. Smith. (2011) The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients. Food and Chemical Toxicology 49:10, pages 2471-2494.
Crossref
. (2011) Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31. EFSA Journal 9:6, pages 2177.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 9:5.
Crossref
. (2010) Scientific Opinion on Flavouring Group Evaluation 25Rev1: Aliphatic and aromatic hydrocarbons from chemical group 31. EFSA Journal 8:5, pages 1334.
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. (2009) Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1) : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8. EFSA Journal 7:2, pages 978.
Crossref
. (2008) Flavouring Group Evaluation 25, (FGE.25) - Aliphatic and aromatic hydrocarbons from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. EFSA Journal 6:12, pages 918.
Crossref
. (2006) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 18 (FGE.18): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aro. EFSA Journal 4:8, pages 331.
Crossref
Rebecca Boyle, Stuart McLean, William Foley, Noel W Davies, Evan J Peacock & Ben Moore. (2001) Metabolites of dietary 1,8-cineole in the male koala (Phascolarctos cinereus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 129:4, pages 385-395.
Crossref
Georgia J Pass, Stuart McLean & Ieva Stupans. (1999) Induction of xenobiotic metabolising enzymes in the common brushtail possum, Trichosurus vulpecula, by Eucalyptus terpenes. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 124:3, pages 239-246.
Crossref
Henrik Rye Lam, Ole Ladefoged, Grete Østergaard, Søren Peter Lund & Leif Simonsen. (2009) Four Weeks’Inhalation Exposure of Rats to p‐Cymene Affects Regional and Synaptosomal Neurochemistry. Pharmacology & Toxicology 79:5, pages 225-230.
Crossref
Mitsuo Miyazawa, Takashi Wada & Hiromu Kameoka. (1996) Biotransformation of α-Terpinene in Common Cutworm Larvae ( Spodoptera litura Fabricius) . Journal of Agricultural and Food Chemistry 44:9, pages 2889-2893.
Crossref
Stuart McLean, William J. Foley, Noel W. Davies, Susan Brandon, Li Duo & Adrian J. Blackman. (1993) Metabolic fate of dietary terpenes fromEucalyptus radiata in common ringtail possum (Pseudocheirus peregrinus). Journal of Chemical Ecology 19:8, pages 1625-1643.
Crossref
Takashi Matsumoto, Noriaki Hayashi, Takashi Ishida & Yoshinori Asakawa. (1990) Metabolites of (+)-dehydroabietic acid in rabbits. Journal of Pharmaceutical Sciences 79:6, pages 540-547.
Crossref
Liv‐Torill Austgulen, Einar Solheim & Ronald R. Scheline. (2009) Metabolism in Rats of p ‐Cymene Derivatives: Carvacrol and Thymol . Pharmacology & Toxicology 61:2, pages 98-102.
Crossref

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