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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 1-2
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Original Article

The peroxidatic function of liver microsomal cytochrome P-450: Comparison of hydrogen peroxide and NADPH-catalysed iV-demethylation reactions

R. W. Estabrook Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA
,
C. Martin-wixtrom Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA
,
Y. Saeki Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA; Central Research Laboratory, Shiga University of Medical Science, Seta, Ohtsu, Shiga, 520-21, Japan
,
R. Renneberg Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA; Central Institute of Molecular Biology, Academy of Sciences of GDR, Department of Applied Enzymology, GDR-1115 Berlin-Buch, Robert-Rossle-Str. 10DR, Germany
,
A. Hildebrandt Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA; Max von Pettenkofer Institut, Bundes Gesundheitsamt, Postfache 330013, D-1000, Berlin 33, FR Germany
&
J. Werringloer Department of Biochemistry, University of Texas Health Science Center, Dallas, TX, 75235, USA; Department of Toxicology, University of Tübingen, Lothar Meyer-Bau Wilhelmstrasse 56, D-7400, Tübingen 1, FR Germany
Pages 87-104 | Received 30 Sep 1983, Published online: 30 Sep 2009

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K. Ruckpaul & R. Renneberg. (2007) Ron Estabrook—A Catalyst of Scientific Interactions Between East and West. Drug Metabolism Reviews 39:2-3, pages 267-270.
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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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Satya Narayan, Patricia L. Bounds & Gary W. Winston. (1990) Differential Induction of Peroxygenase-Dependent Microsomal Aniline Hydroxylase by Chronic Ethanol Ingestion. Drug and Chemical Toxicology 13:2-3, pages 155-172.
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M. Štefek & L. Beneš. (1989) Hydrogen Peroxide-Dependent Liver Microsomal N-Demethylation and N-Oxygenation of Stobadine, a γ-Carboline Antiarrhythmic and Cardioprotective Agent. Xenobiotica 19:6, pages 627-634.
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B. Clement & M. Zimmermann. (1987) Characteristics of the microsomal N-hydroxylation of benzamidine to benzamidoxime. Xenobiotica 17:6, pages 659-667.
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A. M. Weli & B. Lindeke. (1986) Peroxidative N-oxidation and N-dealkylation reactions of pargyline. Xenobiotica 16:3, pages 281-288.
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N. Premereur, C. Van Den Branden & F. Roels. (1985) Demonstration of H2O2 production in vivo during aminopyrine metabolism and phenobarbital induction. Archives Internationales de Physiologie et de Biochimie 93:3, pages 241-248.
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Articles from other publishers (33)

Alexander V. LyubimovEugene G. Hrycay & Stelvio M. Bandiera. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Martin Hofrichter, Harald Kellner, Marek J. Pecyna & René Ullrich. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 341 368 .
Eugene G. Hrycay & Stelvio M. Bandiera. (2012) The monooxygenase, peroxidase, and peroxygenase properties of cytochrome P450. Archives of Biochemistry and Biophysics 522:2, pages 71-89.
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James R. Reed, Lauren M. Brignac-Huber & Wayne L. Backes. (2008) Physical Incorporation of NADPH-Cytochrome P450 Reductase and Cytochrome P450 into Phospholipid Vesicles Using Glycocholate and Bio-Beads. Drug Metabolism and Disposition 36:3, pages 582-588.
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Paul R. Ortiz de Montellano & James J. De Voss. 2005. Cytochrome P450. Cytochrome P450 183 245 .
Peter Hlavica. (2004) Models and mechanisms of O‐O bond activation by cytochrome P450. European Journal of Biochemistry 271:22, pages 4335-4360.
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James R. Reed & Paul F. Hollenberg. (2003) Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5. Journal of Inorganic Biochemistry 93:3-4, pages 152-160.
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Zaineb Fadhel, Zijing Lu, Larry W. Robertson & Howard P. Glauert. (2002) Effect of 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats. Toxicology 175:1-3, pages 15-25.
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Yutaka Maruyama, Hiroki Teraoka, Hisato Iwata, Akio Kazusaka & Shoichi Fujita. (2001) Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochemistry International 38:7, pages 567-572.
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M. R. Anari, S. Khan, S. D. Jatoe & P. J. O’Brien. (1997) Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes. European Journal of Drug Metabolism and Pharmacokinetics 22:4, pages 305-310.
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Catherine S.E Jewell, Maxwell H Mayeaux & Gary W Winston. (1997) Benzo[a]pyrene Metabolism by the Hepatopancreas and Green Gland of the Red Swamp Crayfish, Procambarus clarkii, In Vitro. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 118:3, pages 369-374.
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P. Hlavica, I. Golly, M. Lehnerer & J. Schulze. (2016) Primary aromatic amines: their N-oxidative bioactivation. Human & Experimental Toxicology 16:8, pages 441-448.
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Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
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Paul R. Ortiz de Montellano. 1995. Cytochrome P450. Cytochrome P450 245 303 .
Peter Hlavica & Ute Künzel-Mulas. (1993) Metabolic N-oxide formation by rabbit-liver microsomal cytochrome P-4502B4: involvement of superoxide in the NADPH-dependent N-oxygenation of N,N-dimethylaniline. Biochimica et Biophysica Acta (BBA) - General Subjects 1158:1, pages 83-90.
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A. Bast, K. Smid & H. Timmerman. (1989) The effects of cimetidine, ranitidine and famotidine on rat hepatic microsomal cytochrome P-450 activities. Agents and Actions 27:1-2, pages 188-191.
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Jean A. Boutin, Georges E.N. Kass & Peter Moldéus. (1989) Drug-induced hydrogen peroxide production in isolated rat hepatocytes. Toxicology 54:2, pages 129-137.
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B. Clement. (1989) STRUCTURAL REQUIREMENTS OF MICROSOMAL N-OXYGENATIONS DERIVED FROM STUDIES ON AMIDINES. Drug Metabolism and Drug Interactions 7:1.
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Catherine S.E. Jewell & Gary W. Winston. (1989) Characterization of the microsomal mixed-function oxygenase system of the hepatopancreas and green gland of the red swamp crayfish, Procambarus clarkii. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 92:2, pages 329-339.
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Steven G. Nadler & Henry W. Strobel. (1988) Role of electrostatic interactions in the reaction of NADPH-cytochrome P-450 reductase with cytochromes P-450. Archives of Biochemistry and Biophysics 261:2, pages 418-429.
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Bernd Clement & Martin Zimmermann. (1987) Hepatic microsomal N-demethylation of N-methylbenzamidine. Biochemical Pharmacology 36:19, pages 3127-3133.
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Tan Youzhuang, Larry K. Keefer & Chung S. Yang. (1987) Inhibition of microsomal N-nitrosodimethylamine demethylase by diethyl ether and other anesthetics. Biochemical Pharmacology 36:12, pages 1973-1978.
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Zainab A. F. Al-Bayati, Wallace J. Murray & Sidney J. Stohs. (1987) 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced lipid peroxidation in hepatic and extrahepatic tissues of male and female rats. Archives of Environmental Contamination and Toxicology 16:2, pages 159-166.
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M.Q. Hassan, H. Mohammadpour, S.J. Hermansky, W.J. Murray & S.J. Stohs. (1987) Comparative effects of BHA and ascorbic acid on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. General Pharmacology: The Vascular System 18:5, pages 547-550.
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Gábor Gullner & Ernö Tyihák. (1987) Hydrogen peroxide dependent N-demethylase activity in the leaves of normal and heat-shocked bean plants. Plant Science 52:1-2, pages 21-27.
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Randy H. Weiss & Ronald W. Estabrook. (1986) The mechanism of cumene hydroperoxide-dependent lipid peroxidation: The function of cytochrome P-450. Archives of Biochemistry and Biophysics 251:1, pages 348-360.
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Catharina Bäärnhielm & Göran Hansson. (1986) Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Biochemical Pharmacology 35:9, pages 1419-1425.
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Aalt Bast. (1986) Is formation of reactive oxygen by cytochrome P-450 perilous and predictable?. Trends in Pharmacological Sciences 7, pages 266-270.
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Elizabeth K. Marker & Arun P. Kulkarni. (1986) Cumene hydroperoxide-supported denitrification of 2-nitropropane in uninduced mouse liver microsomes. International Journal of Biochemistry 18:7, pages 595-601.
Crossref
G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 39 81 .
Paul R. Ortiz de Montellano. 1986. Cytochrome P-450. Cytochrome P-450 217 271 .
S. J. Stohs, Z. F. Al-Bayati, M. Q. Hassan, W. J. Murray & H. A. Mohammadpour. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 357 365 .
Afaf M. Weli & Björn Lindere. (1985) The metabolic fate of pargyline in rat liver microsomes. Biochemical Pharmacology 34:11, pages 1991-1998.
Crossref

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