Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 1-2
35
Views
81
CrossRef citations to date
0
Altmetric
Original Article

Human cytochromes P-450

&
Pages 151-185 | Received 18 Jul 1983, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (17)

Olavi Pelkonen. (2002) Human CYPs: in vivo and clinical aspects. Drug Metabolism Reviews 34:1-2, pages 37-46.
Read now
Agneta Löf & Gunnar Johanson. (1998) Toxicokinetics of Organic Solvents: A Review of Modifying Factors. Critical Reviews in Toxicology 28:6, pages 571-650.
Read now
O. PELKONEN, J. MÄEENPÄEÄ, P. TAAVITSAINEN, A. RAUTIO & H. RAUNIO. (1998) Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28:12, pages 1203-1253.
Read now
M. K. Bayliss, J. A. Bell, K. Wilson & G. R. Park. (1994) 7-Ethoxycoumarin O-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions. Xenobiotica 24:3, pages 231-241.
Read now
Steven A. Wrighton, Mark Vandenbranden, Jeffrey C. Stevens, Lisa A. Shipley, Barbara J. Ring, John R. Cashman & Allan E. Rettie. (1993) In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development. Drug Metabolism Reviews 25:4, pages 453-484.
Read now
Steven A. Wrighton & Jeffrey C. Stevens. (1992) The Human Hepatic Cytochromes P450 Involved in Drug Metabolism. Critical Reviews in Toxicology 22:1, pages 1-21.
Read now
K. Lavrijsen, J. Van Houdt, D. Van Dyck, J. Hendrickx, M. Bockx, R. Hurkmans, W. Meuldermans, L. Le Jeune, W. Lauwers & J. Heykants. (1992) Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes. Xenobiotica 22:7, pages 815-836.
Read now
A. G. Renwick. (1991) Safety factors and establishment of acceptable daily intakes. Food Additives & Contaminants 8:2, pages 135-149.
Read now
Y. C. Lou. (1990) Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians. Drug Metabolism Reviews 22:5, pages 451-475.
Read now
Robert L. Bronaugh, Steven W. Collier, Jan E. Storm & Raymond F. Stewart. (1989) In Vitro Evaluation of Skin Absorption and Metabolism. Journal of Toxicology: Cutaneous and Ocular Toxicology 8:4, pages 453-467.
Read now
F. Berthou, D. Ratanasavanh, C. Riche, D. Picart, T. Voirin & A. Guillouzo. (1989) Comparison of Caffeine Metabolism by Slices, Microsomes and Hepatocyte Cultures from Adult Human Liver. Xenobiotica 19:4, pages 401-417.
Read now
Leif-å Svensson & Anders Tunek. (1988) The design and bioactivation of presystemically stable prodrugs. Drug Metabolism Reviews 19:2, pages 165-194.
Read now
F. P. Guengerich, D. R. Umbenhauer, P. F. Churchill, P. H. Beaune, R. Böcker, R. G. Knodell, M. V. Martin & R. S. Lloyd. (1987) Polymorphism of human cytochrome P-450. Xenobiotica 17:3, pages 311-316.
Read now
GuyD. Griffin, B. Zane Egan, NormanE. Lee & CarlA. Burtis. (1986) Induction of mixed—function oxidase activity in mouse lymphoid tissues by polycyclic aromatic hydrocarbons. Journal of Toxicology and Environmental Health 19:2, pages 185-194.
Read now
H. Souhaili-El Amri, A. M. Batt & G. Siest. (1986) Comparison of cytochrome P-450 content and activities in liver microsomes of seven animal species, including man. Xenobiotica 16:4, pages 351-358.
Read now

Articles from other publishers (64)

Kayo Ikeda, Kazuro Ikawa, Toshihiro Kozumi, Satoko Yokoshige, Shunji Horikawa & Norifumi Morikawa. (2012) Development and validation of a GC-EI-MS method with reduced adsorption loss for the quantification of olanzapine in human plasma. Analytical and Bioanalytical Chemistry 403:7, pages 1823-1830.
Crossref
Qing-Lan Wang, Quoc Wu, Yan-Yan Tao, Cheng-Hai Liu & Hani El-Nezami. (2011) Salvianolic acid B modulates the expression of drug-metabolizing enzymes in HepG2 cells. Hepatobiliary & Pancreatic Diseases International 10:5, pages 502-508.
Crossref
M E McManus, D S Davies, A R Boobis, P H Grantham & P J Wirth. (1987) Guanethidine N -oxidation in human liver microsomes . Journal of Pharmacy and Pharmacology 39:12, pages 1052-1055.
Crossref
Socorro Espuelas, Maite Agüeros, Irene Esparza & Juan M. Irache. 2011. Intracellular Delivery. Intracellular Delivery 487 509 .
Nathalie Khoueiry ZgheibZahi MitriEddy GeryessPakiza Noutsi. (2010) Cytochrome P4502E1 ( CYP2E1 ) Genetic Polymorphisms in a Lebanese Population: Frequency Distribution and Association with Morbid Diseases . Genetic Testing and Molecular Biomarkers 14:3, pages 393-397.
Crossref
Anthony H.Lu & Shiew-Mei Huang. 2004. New Drug Development. New Drug Development 87 110 .
Maria-Cristina Carrillo, Setsuko Kanai, Kyoko Miyasaka & Kenichi Kitani. (2002) A protein free diet uncovers the potential age-difference in the hepatic detoxifying system, glutathione S-transferase, in female mice. Mechanisms of Ageing and Development 123:12, pages 1617-1623.
Crossref
Balaji Agoram, Walter S. Woltosz & Michael B. Bolger. (2001) Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Advanced Drug Delivery Reviews 50, pages S41-S67.
Crossref
K. Kitani. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 341 366 .
Kenichi Kitani. (1994) Aging and the liver: fucntional aspects. Archives of Gerontology and Geriatrics 19:2, pages 145-158.
Crossref
Mayumi Mimura, Hiroshi Yamazaki, Chikako Sugahara, Toyoko Hiroi, Yoshihiko Funae & Tsutomu Shimada. (1994) Differential roles of cytochromes P450 2D1, 2C11, and 1A1/2 in the hydroxylation of bufuralol by rat liver microsomes. Biochemical Pharmacology 47:11, pages 1957-1963.
Crossref
Edoardo Spina & Achille P. Caputi. (1994) Pharmacogenetic aspects in the metabolism of psychotropic drugs: Pharmacokinetic and clinical implications. Pharmacological Research 29:2, pages 121-137.
Crossref
O. Pelkonen & D. D. Breimer. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 289 332 .
M. Paolini, G. L. Biagi, C. Bauer & G. Cantelli‐Forti. (2013) Cocktail Strategy: Complications and Limitations. The Journal of Clinical Pharmacology 33:11, pages 1011-1012.
Crossref
James A. Bond. (1993) Metabolism and Elimination of Inhaled Drugs and Airborne Chemicals from the Lungs. Pharmacology & Toxicology 72, pages 36-47.
Crossref
Robert R. Evans & Mary V. Relling. (1992) Automated high-performance liquid chromatographic assay for the determination of 7-ethoxycoumarin and umbelliferone. Journal of Chromatography B: Biomedical Sciences and Applications 578:1, pages 141-145.
Crossref
Kenichi Kitani. (1992) Liver and aging. Gastroenterologia Japonica 27:2, pages 276-285.
Crossref
Setsuko Kanai, Yuko Sato & Kenichi Kitani. (1992) The effect of age on the biliary transport maximum (Tm) of bile salts in rats. Archives of Gerontology and Geriatrics 14:2, pages 101-115.
Crossref
M. Manno, R. Ferrara, S. Cazzaro, P. Rigotti & E. Ancona. (2009) Suicidal Inactivation of Human Cytochrome P‐450 by Carbon Tetrachloride and Halothane in Vitro . Pharmacology & Toxicology 70:1, pages 13-18.
Crossref
O. V. Gladyshev, S. I. Kolesnikov & I. T. Reshetneva. (1991) Immunohistochemical localization of cytochrome P-450. Bulletin of Experimental Biology and Medicine 112:6, pages 1810-1812.
Crossref
Daniel Stralka & Henry W. Strobel. (1991) Characterization of cytochrome P450-dependent dimethylhydrazine metabolism in human colon microsomes. Cancer 68:11, pages 2363-2369.
Crossref
Steffen Loft, Victoria Otton, Martin S. Lennard, Geoffrey T. Tucker & Henrik E. Poulsen. (1991) Characterization of metronidazole metabolism by human liver microsomes. Biochemical Pharmacology 41:8, pages 1127-1134.
Crossref
Kenichi Kitani. (1991) Aging of the liver: facts and theories. Archives of Gerontology and Geriatrics 12:2-3, pages 133-154.
Crossref
V.M. Morrison, A.K. Burnett, L.M. Forrester, C.R. Wolf & J.A. Craft. (1991) The contribution of specific cytochromes P-450 in the metabolism of 7,12-dimethylbenz[a]anthracene in rat and human liver microsomal membranes. Chemico-Biological Interactions 79:2, pages 179-196.
Crossref
P.G. Gervasi, V. Longo, F. Naldi, G. Panattoni & F. Ursino. (1991) Xenobiotic-metabolizing enzymes in human respiratory nasal mucgsa. Biochemical Pharmacology 41:2, pages 177-184.
Crossref
Fabrice MOREL, Philippe H. BEAUNE, Damrong RATANASAVANH, Jean‐Pierre FLINOIS, Chung S. YANG, F. Peter GUENGERICH & André GUILLOUZO. (2005) Expression of cytochrome P ‐450 enzymes in cultured human hepatocytes . European Journal of Biochemistry 191:2, pages 437-444.
Crossref
Steffen Loft. (1990) Metronidazole and Antipyrine as Probes for the Study of Foreign Compound Metabolism. Pharmacology & Toxicology 66, pages 1-31.
Crossref
D Sesardic, AR Boobis, BP Murray, S Murray, J Segura, R de la Torre & DS Davies. (2012) Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.. British Journal of Clinical Pharmacology 29:6, pages 651-663.
Crossref
Allan B. Okey. (1990) Enzyme induction in the cytochrome P-450 system. Pharmacology & Therapeutics 45:2, pages 241-298.
Crossref
M. Barry & J. Feely. (1990) Enzyme induction and inhibition. Pharmacology & Therapeutics 48:1, pages 71-94.
Crossref
QY Yue, JO Svensson, C Alm, F Sjoqvist & J Sawe. (2012) Codeine O‐demethylation co‐segregates with polymorphic debrisoquine hydroxylation.. British Journal of Clinical Pharmacology 28:6, pages 639-645.
Crossref
Robert L. Bronaugh, Raymond F. Stewart & Jan E. Storm. (1989) Extent of cutaneous metabolism during percutaneous absorption of xenobiotics. Toxicology and Applied Pharmacology 99:3, pages 534-543.
Crossref
Colin W. Howden, Gordon G. Birnie & Martin J. Brodie. (1989) Drug metabolism in liver disease. Pharmacology & Therapeutics 40:3, pages 439-474.
Crossref
M. Eichelbaum. 1989. Verhandlungen der Deutschen Gesellschaft für Neurologie. Verhandlungen der Deutschen Gesellschaft für Neurologie 781 788 .
Markku Pasanen, Taina Taskinen, Eero A. Sotaniemi, Matti Kairaluoma & Olavi Pekonen. (2009) Inhibitor Panel Studies of Human Hepatic and Placental Cytochrome P‐450‐Associated Monooxygenase Activities. Pharmacology & Toxicology 62:5, pages 311-317.
Crossref
A. Robillart, M. Zeisser, B. Vailly & J.P. Dupeyron. (1988) Les monooxygénases hépatiques. Annales Françaises d'Anesthésie et de Réanimation 7:2, pages 149-155.
Crossref
G. M. McGuire, G. J. A. Macphee, G. G. Thompson, B. K. Park, M. R. Moore & M. J. Brodie. (1988) The effects of chronic carbamazepine treatment on haem biosynthesis in man and rat. European Journal of Clinical Pharmacology 35:3, pages 241-247.
Crossref
J. J. van Houdt, P. W. H. G. Coenen, G. M. Alink, J. S. M. Boleij & J. H. Koeman. (1988) Organ specific metabolic activation of five extracts of indoor and outdoor particulate matter. Archives of Toxicology 61:3, pages 213-217.
Crossref
G. Goerz & R. Lissner. 1988. Neue Entwicklungen in der Dermatologie. Neue Entwicklungen in der Dermatologie 157 176 .
A. R. Dahl. 1988. Inhalation Toxicology. Inhalation Toxicology 41 65 .
L. Shaw, M.S. Lennard, G.T. Tucker, N.D.S. Bax & H.F. Woods. (1987) Irreversible binding and metabolism of propranolol by human liver microsomes—Relationship to polymorphic oxidation. Biochemical Pharmacology 36:14, pages 2283-2288.
Crossref
Niilo T. Kärki, Risto Pokela, Lauri Nuutinen & Olavi Pelkonen. (2006) Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls. International Journal of Cancer 39:5, pages 565-570.
Crossref
HS Purba, JL Maggs, ML Orme, DJ Back & BK Park. (2012) The metabolism of 17 alpha‐ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.. British Journal of Clinical Pharmacology 23:4, pages 447-453.
Crossref
Lisa B.G. Tee, Donald S. Davies, Caroline E. Seddon & Alan R. Boobis. (1987) Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Biochemical Pharmacology 36:7, pages 1041-1052.
Crossref
A.R. Boobis, S. Murray, C.E. Seddon & D.S. Davies. (1987) In vitro studies of induction and inhibition of drug oxidation in man. Pharmacology & Therapeutics 33:1, pages 101-108.
Crossref
Michael E. McManus. (1987) Metabolic characterization of human liver microsomal cytochromes P-450 involved in the oxidation of debrisoquine, bufuralol and the carcinogen 2-acetylaminofluorene. Pharmacology & Therapeutics 33:1, pages 47-53.
Crossref
S. Dragacci, J. Thomassin, J. Magdalou, H. Souhaili El Amri, P. Boissel & G. Siest. (1987) Properties of human hepatic UDP-glucuronosyltransferases. Relationship to other inducible enzymes in patients with cholestasis. European Journal of Clinical Pharmacology 32:5, pages 485-491.
Crossref
M. Eichelbaum. 1987. Funktion und Funktionsdiagnostik der Leber. Funktion und Funktionsdiagnostik der Leber 145 160 .
Osamu Inoue, Kazunori Seiji, Takao Watanabe, Miyuki Kasahara, Haruo Nakatsuka, Songnian Yin, Guilan Li, Shixiong Cai, Chui Jin & Masayuki Ikeda. (1986) Possible ethnic difference in toluene metabolism: A com- parative study among chinese, turkish and japanese sol- vent workers. Toxicology Letters 34:2-3, pages 167-174.
Crossref
Alan R. Buckpitt & Linda S. Bahnson. (1986) Naphthalene metabolism by human lung microsomal enzymes. Toxicology 41:3, pages 333-341.
Crossref
C. Bäärnhielm, H. Dahlbäck & I. Skånberg. (2009) In Vivo Pharmacokinetics of Felodipine Predicted from in Vitro Studies in Rat, Dog and Man . Acta Pharmacologica et Toxicologica 59:2, pages 113-122.
Crossref
Allan B. Okey, Eve A. Roberts, Patricia A. Harper & Michael S. Denison. (1986) Induction of drug-metabolizing enzymes: Mechanisms and consequences. Clinical Biochemistry 19:2, pages 132-141.
Crossref
W. Kalow. (1986) Genetics of drug transformation. Clinical Biochemistry 19:2, pages 76-82.
Crossref
J.M. Neis, S.H. Yap, P.J.L. van Gemert, H.M.J. Roelofs, R.P. Bos & P.Th. Henderson. (1986) Activation of mutagens by hepatocytes and liver 9000 × g supernatant from human origin in the Salmonella typhimurium mutagenicity assay. Mutation Research/Environmental Mutagenesis and Related Subjects 164:1, pages 41-51.
Crossref
Simon Plummer, Alan R. Boobis & Donald S. Davies. (1986) Is the activation of aflatoxin B1 catalysed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man?. Archives of Toxicology 58:3, pages 165-170.
Crossref
Takashi MATSUBARA, Noriko YAMADA, Toshio MITOMI, Seishichi YOKOYAMA, Yonetaka FUKIISHI, Yasuhiko HASEGAWA & Hideo NISHIMURA. (1986) Cytochrome P-450-Dependent Monooxygenase Activities in Prenatal and Postnatal Human Livers: Comparison of Human Liver 7-Alkoxycoumarin O-Dealkylases with Rat Liver Enzymes. Japanese Journal of Pharmacology 40:3, pages 389-398.
Crossref
G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 82 112 .
Michael R. Waterman, Maliyakal E. John & Evan R. Simpson. 1986. Cytochrome P-450. Cytochrome P-450 345 386 .
M. E. McManus, D. J. Birkett, W. M. Burgess, I. Stupans, J. A. Koenig, A. R. Boobis, D. S. Davies, P. J. Wirth, P. H. Grantham & S. S. Thorgeirsson. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 773 779 .
F. Peter Guengerich, Tsutomu Shimada, Diane R. Umbenhauer, Martha V. Martin, Kunio S. Misono, Linda M. Distlerath, Paul E. B. Reilly & Thomas Wolff. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 83 94 .
GC Kahn, AR Boobis, MJ Brodie, EL Toverud, S Murray & DS Davies. (2012) Phenacetin O‐deethylase: an activity of a cytochrome P‐450 showing genetic linkage with that catalysing the 4‐hydroxylation of debrisoquine?. British Journal of Clinical Pharmacology 20:1, pages 67-76.
Crossref
AR Boobis, CE Hampden, S Murray, P Beaune & DS Davies. (2012) Attempts to phenotype human liver samples in vitro for debrisoquine 4‐ hydroxylase activity.. British Journal of Clinical Pharmacology 19:6, pages 721-729.
Crossref
Alan R. Boobis, Jamie McQuade, Dorothea Sesardic, Richard T. Robson, Chris Hayward, Edward A. Lock, Cliff R. Elcombe, Michael S. Rose & Donald S. Davies. (1985) A monoclonal antibody raised to rat liver cytochrome P-448 (form c) which recognises an epitope common to many other forms of cytochrome P-450. Biochemical Pharmacology 34:10, pages 1671-1681.
Crossref
Lennart Eberson. (1985) The Marcus theory of electron transfer, a sorting device for toxic compounds. Advances in Free Radical Biology & Medicine 1:1, pages 19-90.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.