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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 6
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Original Article

Absorption, metabolism and excretion studies on clavulanic acid in the rat and dog

G. C. Bolton Drug Metabolism Unit, Beecham Pharmaceuticals Research Division, The Pinnacles, Coldharbour Road, Harlow, Essex, CM19 SAD, UK
,
G. D. Allen Drug Metabolism Unit, Beecham Pharmaceuticals Research Division, The Pinnacles, Coldharbour Road, Harlow, Essex, CM19 SAD, UK
,
C. W. Filer Drug Metabolism Unit, Beecham Pharmaceuticals Research Division, The Pinnacles, Coldharbour Road, Harlow, Essex, CM19 SAD, UK
&
D. J. Jeffery Drug Metabolism Unit, Beecham Pharmaceuticals Research Division, The Pinnacles, Coldharbour Road, Harlow, Essex, CM19 SAD, UK
Pages 483-490 | Received 13 Jul 1983, Published online: 30 Sep 2009

Citations (14)

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Read on this site (3)

CarlosM. Carceles, M. Soledad Vicente & Elisa Escudero. (1995) Pharmacokinetics of amoxicillin‐clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens. Avian Pathology 24:4, pages 643-652.
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C.M. Carceles, E. Escudero, M.S. Vicente, J.M. Serrano & S. Carli. (1995) Pharmacokinetics of amoxicillin/clavulanic acid combination after intravenous and oral administration in goats. Veterinary Quarterly 17:4, pages 134-138.
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G. C. Bolton, G. D. Allen, B. E. Davies, C. W. Filer & D. J. Jeffery. (1986) The disposition of clavulanic acid in man. Xenobiotica 16:9, pages 853-863.
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Articles from other publishers (11)

Andrea Kleindienst, Francisco Marin & Frank Dodoo-Schittko. (2015) Dysphagia Diagnosed by Fiberoptic Endoscopy Is Common and Transient in Critical Illness Polyneuropathy. Critical Care Medicine 43:2, pages 492-493.
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Katrina L. Mealey. (2001) Penicillins and -lactamase inhibitor combinations. Journal of the American Veterinary Medical Association 218:12, pages 1893-1896.
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Marc L. Hautekeete, Yves Horsmans, Christine van Waeyenberge, Christian Demanet, Jean Henrion, Louis Verbist, Reginald Brenard, Christine Sempoux, Peter P. Michielsen, Paul S.H. Yap, Jacques Rahier & Andre P. Geubel. (1999) HLA association of amoxicillin-clavulanate–induced hepatitis. Gastroenterology 117:5, pages 1181-1186.
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Elisa Escudero, M. Soledad Vicente & Carlos Mario Carceles. (1998) Pharmacokinetics of amoxicillin/clavulanic acid combination after intravenous and intramuscular administration to pigeons. Research in Veterinary Science 65:1, pages 77-81.
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E. Escudero, C.M. Carceles & S. Vicente. (1996) Pharmacokinetics of amoxicillin/ciavulanic acid combination and of both drugs alone after intravenous administration to goats. British Veterinary Journal 152:5, pages 551-559.
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Nicholas G. Ryley, Kenneth A. Fleming & Roger W.G. Chapman. (1995) Focal destructive cholaugiopathy associated with amoxycillin/clavulanicacid (Augmentin). Journal of Hepatology 23:3, pages 278-282.
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C.M. CARCELES, E. ESCUDERO & J.D. BAGGOT. (2008) Comparative pharmacokinetics of amoxicillin/clavulanic acid combination after intravenous administration to sheep and goats. Journal of Veterinary Pharmacology and Therapeutics 18:2, pages 132-136.
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K ColemanD R GriffinP A Upshon. (1991) Pharmacokinetic studies and renal dehydropeptidase stability of the new beta-lactamase inhibitor BRL 42715 in animals. Antimicrobial Agents and Chemotherapy 35:9, pages 1748-1752.
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Marc Verhamme, Carlos Ramboer, Peter Van De Bruaene & Nirwan Inderadjaja. (1989) Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation. Journal of Hepatology 9:2, pages 260-264.
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Jun Haginaka, Hiroyuki Yasuda, Toyozo Uno & Terumichi Nakagawa. (1986) High-performance liquid chromatographic assay of clavulanate in human plasma and urine by fluorimetric detection. Journal of Chromatography B: Biomedical Sciences and Applications 377, pages 269-277.
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Derrick Jackson, Andrew Cockburn, Denis L. Cooper, Peter F. Langley, Tim C.G. Tasker & David J. White. (1985) Clinical pharmacology and safety evaluation of timentin. The American Journal of Medicine 79:5, pages 44-55.
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