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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 7
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Original Article

Glutathione transferase-mediated and non-enzymatic activation and detoxication of the N-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen

K. Saito Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160, Japan
,
Y. Yamazoe Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160, Japan
,
T. Kamataki Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160, Japan
&
R. Kato Department of Pharmacology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160, Japan
Pages 545-548 | Received 28 Nov 1983, Published online: 30 Sep 2009

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Margherita Strolin Benedetti, Rhys Whomsley, Italo Poggesi, Willi Cawello, François-Xavier Mathy, Marie-Laure Delporte, Peggy Papeleu & Jean-Baptiste Watelet. (2009) Drug metabolism and pharmacokinetics. Drug Metabolism Reviews 41:3, pages 344-390.
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I. K. Thomas, A. Koizumi & T. Imamura. (1986) Suppressive effect of O,O‐dimethyl, S‐ethyl phosphorothioate on immune response. Journal of Toxicology and Environmental Health 19:4, pages 465-476.
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Articles from other publishers (10)

Fang Zhao, Jing‑Fen Su, Shu‑Min Lun, Yong‑Jie Hou, Li‑Juan Duan, Neng‑Chao Wang, Fang‑Fang Shen, Yao‑Wen Zhang, Zhao‑Wei Gao, Jing Li, Xian‑Juan Du & Fu‑You Zhou. (2019) Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high‑incidence area of northern China. Oncology Letters.
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In-Sung Kim, Ji-Hee Hwang, Masashi Hirano, Hisato Iwata & Eun-Young Kim. (2016) In vitro and in silico evaluation of transactivation potencies of avian AHR1 and AHR2 by endogenous ligands: Implications for the physiological role of avian AHR2. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 187, pages 1-9.
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W. Teubner, J. I. Fuchs & P. Steinberg. (2006) Enhanced glutathione S-transferase expression in 2-hydroxyamino- 1-methyl-6-phenylimidazo[4,5-b]pyridine-resistant IEC-18 cells. Cell Biology and Toxicology 23:3, pages 153-161.
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H. Glatt. 2006. Acrylamide and Other Hazardous Compounds in Heat-Treated Foods. Acrylamide and Other Hazardous Compounds in Heat-Treated Foods 358 404 .
Hyang-Sook Chun, Paul A. Kuzmicky, Norman Y. Kado & Robert H. Rice. (2000) Toxicity of Trp-P-2 to cultured human and rat keratinocytes. Chemico-Biological Interactions 127:3, pages 237-253.
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Tim Marczylo & Costas Ioannides. (1999) Evidence for the presence of a microsomal NADH-dependent enzyme system that can bioactivate aromatic amines in the liver of rats and mice. Toxicology 134:2-3, pages 127-141.
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G. Eisenbrand & W. Tang. (1993) Food-borne heterocyclic amines. Chemistry, formation, occurrence and biological activities. A literature review. Toxicology 84:1-3, pages 1-82.
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Medhat Abu-Zeid, Norma Staiano, Yasushi Yamazoe & Ryuichi Kato. (1990) Enhancement by Cysteinyl Thiols of Acetyltransferase-mediated, but Not of Sulfotransferase-mediated, Binding of a Pyrolysate-derived N-Hydroxyarylamine, 2-Hydroxyamino-6-methyldipyrido[1,2- a :3′,2′- d ]imidazole, to DNA . Japanese Journal of Cancer Research 81:6-7, pages 653-659.
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W.E. Brennan-Craddock, S. Neale, A.K. Mallett & I.R. Rowland. (1989) Developmental changes in hepatic activation of dietary mutagens by mice. Chemico-Biological Interactions 71:4, pages 367-379.
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Imad K. Thomas & Toshiko Imamura. (1986) Modulation of cellular and humoral immune responses by O,S,S-trimethyl phosphorodithioate, an impurity of commercial malathion. Toxicology 39:1, pages 1-12.
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