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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 7
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Original Article

Cholesterol ester formation by transesterification of chlorambucil: A novel pathway in drug metabolism

P. O. Gunnarsson AB Leo Research Laboratories, Box 941, S-251 09, Helsingborg, Sweden
,
S. Å. Johansson AB Leo Research Laboratories, Box 941, S-251 09, Helsingborg, Sweden
&
L. Svensson AB Leo Research Laboratories, Box 941, S-251 09, Helsingborg, Sweden
Pages 569-574 | Received 28 Nov 1983, Accepted 08 Mar 1984, Published online: 30 Sep 2009

Citations (16)

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Hideo Kaneko, Yasuko Takamatsu, Yasuyoshi Okuno, Junko Abiko, Akira Yoshitake & Junshi Miyamoto. (1988) Substrate specificity for formation of cholesterol ester conjugates from fenvalerate analogues and for granuloma formation. Xenobiotica 18:1, pages 11-19.
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Articles from other publishers (15)

Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 357 422 .
Richard B. Silverman. 2004. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 405 495 .
B. Walther, P. Vis & A. Taylor. 1996. Lipophilicity in Drug Action and Toxicology. Lipophilicity in Drug Action and Toxicology 253 261 .
Peter F. Dodds. (1995) Xenobiotic lipids: The inclusion of xenobiotic compounds in pathways of lipid biosynthesis. Progress in Lipid Research 34:3, pages 219-247.
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Eugen Musch, Mouhamad Malek, Jasna Peter-Katalinic, Heinz Egge, Hermann Rink, Bernd Lathan & Eberhard Riedel. (1992) Cellular kinetics of prednimustine versus chlorambucil plus prednisolone in vitro. Cancer Chemotherapy and Pharmacology 29:4, pages 297-304.
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Harkishan Singh, Dharam Paul Jindal, Mange Ram Yadav & Manoj Kumar. 1991. 233 300 .
Peter F. Dodds. (1991) Incorporation of xenobiotic carboxylic acids into lipids. Life Sciences 49:9, pages 629-649.
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Lars Bastholt, Carl-Johan Johansson, Per Pfeiffer, Leif Svensson, Sven-�ke Johansson, Per Olov Gunnarsson & Henning Mouridsen. (1991) A pharmacokinetic study of prednimustine as compared with prednisolone plus chlorambucil in cancer patients. Cancer Chemotherapy and Pharmacology 28:3, pages 205-210.
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Matthias M. Oppitz, Eugen Musch, Mouhammad Malek, Hans P. Rüb, Gerd E. von Unruh, Ulrich Loos & Brigitte Mühenbruch. (1989) Studies on the pharmacokinetics of chlorambucl and prednimustine in patients using a new high-performance liquid chromatographic assay. Cancer Chemotherapy and Pharmacology 23:4, pages 208-212.
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Hari K. Bhat & G.A.S. Ansari. (1989) Chromatographic separation of cholesteryl acetate and its chloro analogues. Journal of Chromatography A 462, pages 467-470.
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Hari K. Bhat & G. A. S. Ansari. (1989) Covalent interaction of chloroacetic and acetic acids with cholesterol. Journal of Biochemical Toxicology 4:3, pages 189-193.
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Elisabeth Kruse, Sven-Åke Johansson, Beryl Hartley-Asp & Per Olov Gunnarsson. (1988) Distribution and metabolism of estramustine in HeLa cells and the human prostatic tumour cell line 1013L. Biochemical Pharmacology 37:16, pages 3161-3167.
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Junshi Miyamoto, Hideo Kaneko & Yasuko Takamatsu. (2006) Stereoselective formation of a cholesterol ester conjugate from fenvalerate by mouse microsomal carboxyesterase(s). Journal of Biochemical Toxicology 1:2, pages 79-93.
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Yasuyoshi Okuno, Takaki Seki, Seiichi Ito, Hideo Kaneko, Tomoyuki Watanabe, Tomoyuki Yamada & Junshi Miyamoto. (1986) Differential metabolism of fenvalerate and granuloma formation. Toxicology and Applied Pharmacology 83:1, pages 157-169.
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Hideo Kaneko, Masatoshi Matsuo & Junshi Miyamoto. (1986) Differential metabolism of fenvalerate and granuloma formation. Toxicology and Applied Pharmacology 83:1, pages 148-156.
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