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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 8
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Original Article

Disposition and metabolism of amosulalol hydrochloride, a new combined α- and β-adrenoceptor blocking agent, in rats, dogs and monkeys

H. Sasaki Drug Metabolism Group and Physico-Analysis Group, Yamanouchi Pharmaceutical Co., Ltd, No. 1-8 Azusawa-1-chome, Itabashi-ku, Tokyo, 174, Japan
,
H. Kamimura Drug Metabolism Group and Physico-Analysis Group, Yamanouchi Pharmaceutical Co., Ltd, No. 1-8 Azusawa-1-chome, Itabashi-ku, Tokyo, 174, Japan
,
H. Kaniwa Product Development Laboratories, Yamanouchi Pharmaceutical Co., Ltd, No. 1-8 Azusawa-1-chome, Itabashi-ku, Tokyo, 174, Japan
,
S. Kawamura Drug Metabolism Group and Physico-Analysis Group, Yamanouchi Pharmaceutical Co., Ltd, No. 1-8 Azusawa-1-chome, Itabashi-ku, Tokyo, 174, Japan
,
M. Takaichi Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokaimura, Nakagun, Ibaraki, 319-11, Japan
&
T. Yokoshima Tokai Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokaimura, Nakagun, Ibaraki, 319-11, Japan
Pages 621-631 | Received 08 Sep 1983, Published online: 30 Sep 2009

Citations (10)

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Read on this site (3)

Y. Soeishi, H. Matsushima, Y. Teraya, T. Watanabe, S. Higuchi & H. Kaniwa. (1996) Metabolism of tamsulosin in rat and dog. Xenobiotica 26:3, pages 355-365.
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H. Kamimura, H. Sasaki & S. Kawamura. (1985) Metabolism of amosulalol hydrochloride in man: Quantitative comparison with laboratory animals. Xenobiotica 15:5, pages 413-420.
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H. Kamimura, H. Sasaki & S. Kawamura. (1984) Pharmacokinetics of amosulalol, an α, β-adrenoceptor blocker, in rats, dogs and monkeys. Xenobiotica 14:8, pages 613-620.
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Articles from other publishers (7)

Seigo Sanoh & Shigeru Ohta. (2014) Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics. Biopharmaceutics & Drug Disposition 35:2, pages 71-86.
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Hidetaka Kamimura, Naoyuki Nakada, Katsuhiro Suzuki, Ayako Mera, Kinya Souda, Yuichi Murakami, Kohichiro Tanaka, Takafumi Iwatsubo, Akio Kawamura & Takashi Usui. (2010) Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites. Drug Metabolism and Pharmacokinetics 25:3, pages 223-235.
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Katsuhiro SuzukiHidetaka Kamimura. (2007) Pharmacokinetics and Metabolism of an .ALPHA.,.BETA.-Blocker, Amosulalol Hydrochloride, in Mice: Biliary Excretion of Carbamoyl Glucuronide. Biological and Pharmaceutical Bulletin 30:8, pages 1580-1585.
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YASUHIRO TAMAKI, MAKOTO ARAIE & KENJI MUTA. (1999) Effect of Topical Amosulalol on Tissue Circulation in the Optic Nerve Head. Journal of Ocular Pharmacology and Therapeutics 15:3, pages 217-224.
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Toshihiro Saito, Kazutoshi Yamamoto & Yoshiaki Inagaki. (1992) Hemodynamic effects of amosulalol (YM-09538) in patients with essential hypertension. Current Therapeutic Research 52:5, pages 702-707.
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Toichi Takenaka. (2007) Amosulalol. Cardiovascular Drug Reviews 5:1, pages 117-134.
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Kazuo HONDA, Toichi TAKENAKA, Kumiko SHIONO, Akemi MIYATA-OSAWA & Chieko NAKAGAWA. (1985) Autonomic and Antihypertensive Activity of Oral Amosulalol (YM-09538), a Combined α- and β-Adrenoceptor Blocking Agent in Conscious Rats. Japanese Journal of Pharmacology 38:1, pages 31-41.
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