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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 8
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Original Article

Studies related to the metabolism of anabolic steroids in the horse: The phase I and phase II biotransformation of 19-nortestosterone in the equine castrate

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Pages 647-655 | Received 19 Jul 1983, Accepted 29 Mar 1984, Published online: 30 Sep 2009

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J. Scarth, C. Akre, L. van Ginkel, B. Le Bizec, H. De Brabander, W. Korth, J. Points, P. Teale & J. Kay. (2009) Presence and metabolism of endogenous androgenic–anabolic steroid hormones in meat-producing animals: a review. Food Additives & Contaminants: Part A 26:5, pages 640-671.
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Articles from other publishers (27)

Levent Dirikolu & Andreas F. Lehner. (2023) A review of current chemistry, pharmacology, and regulation of endogenous anabolic steroids testosterone, boldenone, and nandrolone in horses. Journal of Veterinary Pharmacology and Therapeutics 46:4, pages 201-217.
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Caitlin Harding, Marjaana Viljanto, Jocelyn Habershon‐Butcher, Polly Taylor & James Scarth. (2023) Equine metabolism of the selective androgen receptor modulator YK‐11 in urine and plasma following oral administration. Drug Testing and Analysis 15:4, pages 388-407.
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Frédéric Balssa, Michael Fischer & Yves Bonnaire. (2011) Easy stereoselective synthesis of 5α-estrane-3β,17α-diol, the major metabolite of nandrolone in the horse. Steroids 76:7, pages 667-668.
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Philip TealeEdward Houghton. (2010) Metabolism of anabolic steroids and their relevance to drug detection in horseracing. Bioanalysis 2:6, pages 1085-1107.
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Andrew R McKinney. (2009) Modern techniques for the determination of anabolic–androgenic steroid doping in the horse. Bioanalysis 1:4, pages 785-803.
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Ed Houghton & Steve Maynard. 2010. Doping in Sports. Doping in Sports 369 409 .
Philip B. Grace, Erica C. Drake, Philip Teale & Edward Houghton. (2008) Quantification of 19-nortestosterone sulphate and boldenone sulphate in urine from male horses using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 22:19, pages 2999-3007.
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Rosa Ventura, Meritxell Roig, Belén Pérez, Sergi López, Mireia Medina, Jaume Bosch & Jordi Segura. (2008) Detection of the administration of 17 β -nortestosterone in boars by gas chromatography/mass spectrometry . Rapid Communications in Mass Spectrometry 22:12, pages 1863-1870.
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E. Houghton, P. Teale & M.C. Dumasia. (2007) Studies related to the origin of C18 neutral steroids isolated from extracts of urine from the male horse: The identification of urinary 19-oic acids and their decarboxylation to produce estr-4-en-17β-ol-3-one (19-nortestosterone) and estr-4-ene-3,17-dione (19-norandrost-4-ene-3,17-dione) during sample processing. Analytica Chimica Acta 586:1-2, pages 196-207.
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Meritxell Roig, Jordi Segura & Rosa Ventura. (2007) Quantitation of 17β-nandrolone metabolites in boar and horse urine by gas chromatography–mass spectrometry. Analytica Chimica Acta 586:1-2, pages 184-195.
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Andrew R. McKinney, Craig J. Suann & Allen M. Stenhouse. (2007) A stereochemical examination of the equine metabolism of 17α-methyltestosterone. Analytica Chimica Acta 581:2, pages 377-387.
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G. N. W. Leung, E. N. M. Ho, D. K. K. Leung, F. P. W. Tang, T. S. M. Wan, J. H. K. Yeung & H. N. C. Wong. (2005) Metabolic Studies of Clostebol Acetate in Horses. Chromatographia 61:7-8, pages 397-402.
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M. C. Dumasia. (2003) In vivo biotransformation of 17α‐methyltestosterone in the horse revisited: identification of 17‐hydroxymethyl metabolites in equine urine by capillary gas chromatography/mass spectrometry . Rapid Communications in Mass Spectrometry 17:4, pages 320-329.
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Andrew R. McKinney, Damon D. Ridley & Craig J. Suann. (2001) The metabolism of norethandrolone in the horse: characterization of 16-, 20- and 21-oxygenated metabolites by gas chromatography/mass spectrometry. Journal of Mass Spectrometry 36:2, pages 145-150.
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Karen A. Bean & Jack D. Henion. (1997) Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 690:1-2, pages 65-75.
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D. B. Gower, E. Houghton & A. T. Kicman. 1995. Steroid Analysis. Steroid Analysis 468 526 .
Claudia Schoene, Angus N. R. Nedderman & Edward Houghton. (1994) Preliminary study of the metabolism of 17α-methyltestosterone in horses utilizing gas chromatography–mass spectrometric techniques. The Analyst 119:12, pages 2537-2542.
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P.W. Tang, D.L. Crone, C.S. Chu, H.K. Yeung & K. Chan. (1993) Measuring the nandrolone threshold ratio by enzyme-linked immunosorbent assay for 5α-estrane-3β,17α-diol. Analytica Chimica Acta 275:1-2, pages 139-146.
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E. Daeseleire, A. De Guesquière & C. Van Peteghem. (1993) Metabolism of 17β,19-nortestosterone in urine of calves after oral intake and intramuscular administration. Analytica Chimica Acta 275:1-2, pages 95-103.
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E. Houghton, L. Grainger, M. C. Dumasia & P. Teale. (1992) Application of gas chromatography/mass spectrometry to steroid analysis in equine sports: Problems with enzyme hydrolysis. Organic Mass Spectrometry 27:10, pages 1061-1070.
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G. Debruyckere & C. Van Peteghem. (1991) Detection of 19-nortestosterone and its urinary metabolites in miniature pigs by gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 564:2, pages 393-403.
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P. Teale & E. Houghton. (1991) The development of a gas chromatographic/mass spectrometric screening procedure to detect the administration of anabolic steroids to the horse. Biological Mass Spectrometry 20:3, pages 109-114.
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E. Houghton, M.C. Dumasia, P. Teale, S.J. Smith, J. Cox, D. MarshaII & D.B. Gower. (1990) The use of stable isotopes and gas chromatography/mass spectrometry in the identification of steroid metabolites in the equine. Steroids 55:10, pages 433-439.
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M. C. Dumasia & E. Houghton. (1988) Biotransformation of 1-dehydrotestosterone in the equine male castrate: Identification of the neutral unconjugated and glucuronic acid conjugated metabolites in horse urine. Biological Mass Spectrometry 17:5, pages 383-392.
Crossref
E. HOUGHTON, ANNETTE GINN, P. TEALE, M. C. DUMASIA & M. S. MOSS. (2010) Detection of the administration of anabolic preparations of nandrolone to the entire male horse. Equine Veterinary Journal 18:6, pages 491-493.
Crossref
E. Houghton, M.C. Dumasia, P. Teale, M.S. Moss & Sharon Sinkins. (1986) Development of a gas chromatographic—mass spectrometric method using multiple analytes for the confirmatory analysis of anabolic steroid residues in horse urine. Journal of Chromatography B: Biomedical Sciences and Applications 383, pages 1-8.
Crossref
Minoo C. Dumasia, Edward Houghton & Sharon Sinkins. (1986) Development of a gas chromatographic—mass spectrometric method using multiple analytes for the confirmatory analysis of anabolic steroids in horse urine. Journal of Chromatography B: Biomedical Sciences and Applications 377, pages 23-33.
Crossref

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