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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 9
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Original Article

Cytochrome P-450-dependent oxidation of felodipine—a 1,4-dihydropyridine—to the corresponding pyridine

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Pages 719-726 | Received 17 Aug 1983, Published online: 30 Sep 2009

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F. Takayama, K. Saito, Y. Ishii, K. Shiratori & M. Ohtawa. (1991) Sex difference in the stereoselective metabolism of a new dihydropyridine calcium channel blocker, in rat studies in vivo and in vitro. Xenobiotica 21:5, pages 557-568.
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U. G. Eriksson, K. J. Hoffmann, R. Simonsson & C. G. Regårdh. (1991) Pharmacokinetics of the enantiomers of felodipine in the dog after oral and intravenous administration of a pseudoracemic mixture. Xenobiotica 21:1, pages 75-84.
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Articles from other publishers (31)

KIRAN MALLI, LALIT KUMAR & RUCHI VERMA. (2023) FELODIPINE-REVIEW OF ANALYTICAL METHODS DEVELOPED FOR PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS. International Journal of Applied Pharmaceutics, pages 53-59.
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Ioannis Stouras, Theodore Papaioannou, Konstantinos Tsioufis, Aristides Eliopoulos & Despina Sanoudou. (2022) The Challenge and Importance of Integrating Drug–Nutrient–Genome Interactions in Personalized Cardiovascular Healthcare. Journal of Personalized Medicine 12:4, pages 513.
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Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Diane L. Nabb, Bogdan Szostek, Matthew W. Himmelstein, Michael P. Mawn, Michael L. Gargas, Lisa M. Sweeney, Judith C. Stadler, Robert C. Buck & William J. Fasano. (2007) In Vitro Metabolism of 8-2 Fluorotelomer Alcohol: Interspecies Comparisons and Metabolic Pathway Refinement. Toxicological Sciences 100:2, pages 333-344.
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Irene Drizin, Robert J. Altenbach, Steven A. Buckner, Kristi L. Whiteaker, Victoria E. Scott, John F. Darbyshire, Venkata Jayanti, Rodger F. Henry, Michael J. Coghlan, Murali Gopalakrishnan & William A. Carroll. (2004) Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers. Bioorganic & Medicinal Chemistry 12:8, pages 1895-1904.
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Yoji Tokuma & Hideyo Noguchi. (1995) Stereoselective pharmacokinetics of dihydropyridine calcium antagonists. Journal of Chromatography A 694:1, pages 181-193.
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Milena R. Koleva & Tsanko S. Stoychev. (1995) Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone. General Pharmacology: The Vascular System 26:1, pages 225-228.
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J.T.B. StrodeIIIIII, L.T. Taylor, A.L. Howard, D. Ip & M.A. Brooks. (1994) Analysis of felodipine by packed column supercritical fluid chromatography with electron capture and ultraviolet absorbance detection. Journal of Pharmaceutical and Biomedical Analysis 12:8, pages 1003-1014.
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Takashi Sakamoto, Yumi Ohtake, Motofumi Itoh, Shigeru Tabata, Takeo Kuriki & Kazuo Uno. (2005) Determination of felodipine enantiomers using chiral stationary phase liquid chromatography and gas chromatography/mass spectrometry, and the study of their pharmacokinetic profiles in human and dog. Biomedical Chromatography 7:2, pages 99-103.
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P. A. Soons, T. M. T. Mulders, E. Uchida, H. C. Schoemaker, A. F. Cohen & D. D. Breimer. (1993) Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics. European Journal of Clinical Pharmacology 44:2, pages 163-169.
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Margareth Gabrielsson, Kurt-Jürgen Hoffmann & Carl Gunnar Regårdh. (1992) Determination of four carboxylic acid metabolites of felodipine in plasma by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 573:2, pages 265-274.
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Kimberly C. Yedinak & Larry M. Lopez. (2016) Felodipine: A New Dihydropyridine Calcium-Channel Antagonist. DICP 25:11, pages 1193-1206.
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Dg Bailey, Jd Spence, C. Munoz & J.M.O. Arnold. (1991) Interaction of citrus juices with felodipine and nifedipine. The Lancet 337:8736, pages 268-269.
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E Blychert, B Edgar, D Elmfeldt & T Hedner. (2012) A population study of the pharmacokinetics of felodipine.. British Journal of Clinical Pharmacology 31:1, pages 15-24.
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E. Fritschka, M. Claus & Th. Philipp. 1991. Kalziumantagonisten in Klinik und Praxis. Kalziumantagonisten in Klinik und Praxis 27 77 .
T. A. Sutfin, T. Lind, M. Gabrielsson & C. G. Reg»rdh. (1990) Biliary secretion of felodipine metabolites in man after intravenous [14C]felodipine. European Journal of Clinical Pharmacology 38:5, pages 421-424.
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R.H. Böcker, E. Preuss & R. Peter. (1990) High-performance liquid chromatography of the metabolites of nitrendipine and investigation into the metabolic pathways of this dihydropyridine. Journal of Chromatography B: Biomedical Sciences and Applications 530, pages 206-211.
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T. Bratel, B. Billing & R. Dahlqvist. (1989) Felodipine reduces the absorption of theophylline in man. European Journal of Clinical Pharmacology 36:5, pages 481-485.
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C. G. Reg�rdh, B. Edgar, R. Olsson, M. Kendall, P. Collste & C. Shansky. (1989) Pharmacokinetics of felodipine in patients with liver disease. European Journal of Clinical Pharmacology 36:5, pages 473-479.
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S. Capewell, J.A.J.H. Critchley, S. Freestone, A. Pottage & L.F. Prescott. (1988) REDUCED FELODIPINE BIOAVAILABILITY IN PATIENTS TAKING ANTICONVULSANTS. The Lancet 332:8609, pages 480-482.
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AG Renwick, DR Robertson, B. Macklin, V. Challenor, DG Waller & CF George. (2012) The pharmacokinetics of oral nifedipine‐a population study.. British Journal of Clinical Pharmacology 25:6, pages 701-708.
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F P Guengerich, L A Peterson & R H Böcker. (1988) Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.. Journal of Biological Chemistry 263:17, pages 8176-8183.
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F P Guengerich & R H Böcker. (1988) Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines.. Journal of Biological Chemistry 263:17, pages 8168-8175.
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VF Challenor, DG Waller, AG Renwick, BS Gruchy & CF George. (2012) The trans‐hepatic extraction of nifedipine.. British Journal of Clinical Pharmacology 24:4, pages 473-477.
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A. G. renwick, J. Le Vie, V. F. Challenor, D. G. Waller, B. Gruchy & C. F. George. (1987) Factors affecting the pharmacokinetics of nifedipine. European Journal of Clinical Pharmacology 32:4, pages 351-355.
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C. Bäärnhielm, H. Dahlbäck & I. Skånberg. (2009) In Vivo Pharmacokinetics of Felodipine Predicted from in Vitro Studies in Rat, Dog and Man . Acta Pharmacologica et Toxicologica 59:2, pages 113-122.
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Catharina Bäärnhielm & Göran Hansson. (1986) Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Biochemical Pharmacology 35:9, pages 1419-1425.
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Catharina Bäärnhielm*Christer Westerlund. (1986) Quantitative relationships between structure and microsomal oxidation rate of 1,4-dihydropyridines. Chemico-Biological Interactions 58, pages 277-288.
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Kurt-J. Hoffmann & Lars Weidolf. (1985) Identification of felodipine metabolites in rat urine. Biological Mass Spectrometry 12:8, pages 414-423.
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