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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 11
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Original Article

Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins

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Pages 849-859 | Received 05 Dec 1983, Published online: 30 Sep 2009

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Yao Xiao, Yi-Kun Wang, Xue-Rong Xiao, Qi Zhao, Jian-Feng Huang, Wei-Feng Zhu & Fei Li. (2020) Metabolic profiling of coumarins by the combination of UPLC-MS-based metabolomics and multiple mass defect filter. Xenobiotica 50:9, pages 1076-1089.
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J. R. Fry, A. H. Hammond, K. L. Jassi, A. E. Bass, G. Bruce, C. Laughton, P. N. Shaw, I. E. Bylov & S. M. Kovalenko. (2004) Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus. Xenobiotica 34:8, pages 707-722.
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A. Steensma, J. A. Beamand, D. G. Walters, R. J. Price & B. G. Lake. (1994) Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, Cynomolgus monkey and human precision-cut liver slices. Xenobiotica 24:9, pages 893-907.
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M. K. Bayliss, J. A. Bell, K. Wilson & G. R. Park. (1994) 7-Ethoxycoumarin O-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions. Xenobiotica 24:3, pages 231-241.
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JaspreetS. Sidhu, TerranceJ. Kavanagh, MaureenT. Reilly & CurtisJ. Omiecinski. (1993) Direct determination of functional activity of cytochrome p‐4501A1 and nadph DT‐diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry. Journal of Toxicology and Environmental Health 40:2-3, pages 177-194.
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J. R. Fry, M. J. Garle & K. Lal. (1992) Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities. Xenobiotica 22:2, pages 211-215.
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J. Barr, A. J. Weir, K. Brendel & I. G. Sipes. (1991) Liver slices in dynamic organ culture. I. An alternative in vitro technique for the study of rat hepatic drug metabolism. Xenobiotica 21:3, pages 331-339.
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S. A. Horner, J. R. Fry, R. H. Clothier & M. Balls. (1987) The detection of cytotoxicity produced by short-lived reactive intermediates: a study with bromobenzene. Xenobiotica 17:6, pages 777-782.
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V. Rogiers, L. Adriaenssens, Y. Vandenberghe, E. Gepts, A. Callaerts & A. Vercruysse. (1986) Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes. Xenobiotica 16:9, pages 817-826.
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S. A. Horner, J. R. Fry, R. H. Clothier & M. Balls. (1985) A comparison of two cytotoxicity assays for the detection of metabolism-mediated toxicity in vitro: a study with cyclophosphamide. Xenobiotica 15:8-9, pages 681-686.
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Articles from other publishers (28)

Ali Mansour Giurnazi, Michael J Garle, Kishan Lal & Jeffrey R Fry. (1996) 7−Ethoxy−3,4−dimethylcoumarin: A Substrate for a Cytochrome p450-mediated Mono-oxygenase Activity that is Highly Induced by Phenobarbitone and β-Naphthoflavone. Journal of Pharmacy and Pharmacology 48:7, pages 729-733.
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David J Wilkinson & Jeffrey R Fry. (1995) Rat Liver Cytochrome P450-mediated Metabolic Activation of Methoxsalen and Structurally Related Compounds and its Relation to Enzyme Inhibition. Journal of Pharmacy and Pharmacology 47:1, pages 79-84.
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I Leguen, C Carlsson, E Perdu-Durand, P Prunet, P Pärt & J.P Cravedi. (2000) Xenobiotic and steroid biotransformation activities in rainbow trout gill epithelial cells in culture. Aquatic Toxicology 48:2-3, pages 165-176.
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Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
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Dennis C. Morse, Adam P. Stein, Paul E. Thomas & Herbert E. Lowndes. (1998) Distribution and Induction of Cytochrome P450 1A1 and 1A2 in Rat Brain. Toxicology and Applied Pharmacology 152:1, pages 232-239.
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CA Musonda, N. Helsby & JK Chipman. (2016) Effects of quercetin on drug metabolizing enzymes and oxidation of 2', 7-dichlorofluorescin in HepG2 cells. Human & Experimental Toxicology 16:12, pages 700-708.
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R.J. Price, A.B. Renwick, J.A. Beamand, F. Esclangon, P.T. Wield, D.G. Walters & B.G. Lake. (1995) Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food and Chemical Toxicology 33:3, pages 233-237.
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Miranda Cornet, Karin Mertens, André Callaerts, Walter Sonck, Antoine Vercruysse & Vera Rogiers. (1994) Age- and gender-related changes in the hepatic metabolism of 2-methylpropene and relationship to epoxide metabolizing enzymes. Mechanisms of Ageing and Development 74:1-2, pages 103-115.
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Alison H. Hammond & Jeffrey R. Fry. (1992) Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. Biochemical Pharmacology 44:7, pages 1461-1464.
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Sandra Coecke, Karin Mertens, Anja Segaert, André Callaerts, Antoine Vercruysse & Vera Rogiers. (1992) Spectrophotometric measurement of flavin-containing monooxygenase activity in freshly isolated rat hepatocytes and their cultures. Analytical Biochemistry 205:2, pages 285-288.
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Ruud Albers & Daniel W. Rosenberg. (1991) In vivo intestinal metabolism of 7-ethoxycoumarin in the rat: Production and distribution of phase I and II metabolites in the isolated, perfused intestinal loop. Toxicology and Applied Pharmacology 109:3, pages 507-513.
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Alison H. Hammond & Jeffrey R. Fry. (1990) The in vivo induction of rat hepatic cytochrome P450-dependent enzyme activities and their maintenance in culture. Biochemical Pharmacology 40:3, pages 637-642.
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Diane E. Matthew & J.Brian Houston. (1990) Drug metabolizing capacity in vitro and in vivo—I. Biochemical Pharmacology 40:4, pages 743-749.
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R.J. Riley, P. Roberts, N.R. Kitteringham & B.K. Park. (1990) Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes. Biochemical Pharmacology 39:12, pages 1951-1958.
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Karen Dominguez, Julia H. Fentem, Michael J. Garle & Jeffrey R. Fry. (1990) Comparison of Mongolian gerbil and rat hepatic microsomal monooxygenase activities: High coumarin 7-hydroxylase activity in the gerbil. Biochemical Pharmacology 39:10, pages 1629-1631.
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J.H. Fentem, B. Foster, C.O. Mills, R. Coleman & J.K. Chipman. (1990) Biliary excretion of fluorescent cholephiles in hepatocyte couplets: An in vitro model for hepatobiliary and hepatotoxicity studies. Toxicology in Vitro 4:4-5, pages 452-457.
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Christiane Aschmann, Torsten Stork & Otmar Wassermann. (1989) Short-term effects of chlorophenols on the function and viability of primary cultured rat hepatocytes. Archives of Toxicology 63:2, pages 121-126.
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Michael J. Garle & Jeffrey R. Fry. (1989) Detection of reactive metabolites in vitro. Toxicology 54:1, pages 101-110.
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H. Babich, M.K. Sardanaand & E. Borenfreund. (1988) Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2. Cell Biology and Toxicology 4:3, pages 295-309.
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J.Brian Houston, Michael J. Humphrey, Diana E. Matthew & Michael H. Tarbit. (1988) Comparison of two azole antifungal drugs, ketoconazole and fluconazole, as modifiers of rat hepatic monooxygenase activity. Biochemical Pharmacology 37:3, pages 401-408.
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M.J. Garle, J. Khan & J.R. Fry. (1988) Depletion of glutathione by the hepatotoxins paracetamol and bromobenzene, and their non-hepatotoxic analogues, in a fortified liver microsomal system. Toxicology in Vitro 2:4, pages 247-252.
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Jeffrey R. Fry & Pauline Paterson. (1987) Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production, and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes. Biochemical Pharmacology 36:18, pages 3090-3092.
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Ulrich Schöder & Horst Diehl. (1987) Substrate specificity of the carbon monoxide-dependent cytochrome P-450 kinetics. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 913:2, pages 185-194.
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J.K. Chipman, J.E. Davies & P. Paterson. (1987) Mechanisms of butylated hydroxytoluene-mediated modulation of 2-acetylaminofluorene mutagenicity in rat and human hepatocyte/Salmonella assays. Mutation Research/Genetic Toxicology 187:3, pages 105-112.
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S.A. Horner, F. Zucco, J.R. Fry, R.H. Clothier & M. Balls. (1987) Investigation of the cytotoxicity produced by generation of short-lived reactive metabolites in vitro: A study with paracetamol. Toxicology in Vitro 1:3, pages 133-138.
Crossref
Richard Clothier. (2020) Sir. Alternatives to Laboratory Animals 13:2, pages 123-124.
Crossref
Vera Rogiers & Antoine Vercruysse. (2020) 7-ECD Activity in vitro . Alternatives to Laboratory Animals 13:2, pages 123-123.
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. (2012) Communications. British Journal of Pharmacology 85:S1.
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