Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 11
37
Views
25
CrossRef citations to date
0
Altmetric
Original Article

Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: The role of flavin-containing mono-oxygenase and cytochrome P-450 systems

, , , &
Pages 861-866 | Received 19 Jul 1983, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Ian R. Phillips & Elizabeth A. Shephard. (2017) Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 167-181.
Read now
Mohammad Reza Eskandari, Mokhtar Rahmati, Ali Reza Khajeamiri, Farzad Kobarfard, Maryam Noubarani & Himan Heidari. (2014) A new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction. Xenobiotica 44:1, pages 70-76.
Read now
M.-A. Mori, M. Kobayashi, H. Uemura, Y. Mori, T. Miyahara & H. Kozuka. (1993) Metabolism of mephentermine and its derivatives by the microsomal fraction from male Wistar rat livers. Xenobiotica 23:1, pages 11-18.
Read now
B. Schlemper, D. J. Siegers, J. W. Paxton & I. G. C. Robertson. (1993) Rat hepatocyte-mediated metabolism of the experimental anti-tumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide. Xenobiotica 23:4, pages 361-371.
Read now
M.-A. Mori, M. Kobayashi, K. Sakai, K. Nakafuku, Y. Mori & H. Kozuka. (1992) The formation of metabolites of mephentermine by microsomal and cytosolic preparations of male Wistar rat livers. Xenobiotica 22:4, pages 451-457.
Read now
T. Inoue & K. Tanaka. (1990) N-Oxidation and N-demethylation of methylephedrine by rat-liver microsomes. Xenobiotica 20:3, pages 265-271.
Read now
S. D. Roy. (1990) Kinetics of in vitro metabolism of methoxyphenamine in rats. Xenobiotica 20:1, pages 55-70.
Read now
Masa-Aki Mori, Narcisa Uy, Yu Kikuko Sakai, Masami Inoue, Tatsuro Miyahara & Hiroshi Kozuka. (1989) Urinary and Biliary Metabolites of Mephentermine in Male Wistar Rats. Xenobiotica 19:3, pages 287-299.
Read now
T. Baba, H. Yamada, K. Oguri & H. Yoshimura. (1987) A new metabolite of methamphetamine; evidence for formation of N-[(1-methyl-2-phenyl)ethyl]ethanimine N-oxide. Xenobiotica 17:9, pages 1029-1038.
Read now
H. Yamada, K. Oguri & H. Yoshimura. (1986) Effects of several factors on urinary excretion of methamphetamine and its metabolites in rats. Xenobiotica 16:2, pages 137-141.
Read now

Articles from other publishers (14)

Michael D. Berquist, Mitchell R. McGill, Anna Mazur, David L. Findley, Greg Gorman, Cynthia B. Jones & Michael D. Hambuchen. (2020) Effect of bile duct ligation-induced liver dysfunction on methamphetamine pharmacokinetics in male and female rats. Drug and Alcohol Dependence 215, pages 108190.
Crossref
M Mori, M Fujita & H Kozuka. (1985) The effect of phenothiazine and dibenzazepine pretreatment on the metabolism of methamphetamine in rats. Journal of Pharmacy and Pharmacology 37:11, pages 819-820.
Crossref
Sharon K. Krueger & David E. Williams. (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics 106:3, pages 357-387.
Crossref
ARTHUR K. CHO, SHIZUO NARIMATSU & YOSHITO KUMAGAI. (1999) Metabolism of drugs of abuse by cytochromes P450. Addiction Biology 4:3, pages 283-301.
Crossref
Ning-Yuan Li, Yan Li & Edward M. Sellers. (1997) An improved HPLC method for analysis of methamphetamine and its metabolites in plasma. European Journal of Drug Metabolism and Pharmacokinetics 22:4, pages 427-432.
Crossref
K. S. Pang & M. Chiba. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 101 187 .
S. Coecke, A. Segaert, A. Vercruysse & V. Rogiers. (1993) Expression of flavin-containing monooxygenase activity in adult rat hepatocytes under various culture conditions. Toxicology in Vitro 7:4, pages 487-491.
Crossref
Hideyuki Yamada, Koichiro Yuno, Kazuta Oguri & Hidetoshi Yoshimura. (1990) Multiplicity of liver microsomal flavin-containing monooxygenase in the guinea pig: Its purification and characterization. Archives of Biochemistry and Biophysics 280:2, pages 305-312.
Crossref
Janeric Seidegård, Lena Grönquist & Per Olov Gunnarsson. (1990) Metabolism of a novel nitrosourea, tauromustine, in the rat. Biochemical Pharmacology 39:9, pages 1431-1436.
Crossref
Robert L. Fitzgerald, Robert V. Blanke & Alphonse Poklis. (2004) Stereoselective pharmacokinetics of 3,4‐methylenedioxymethamphetamine in the rat. Chirality 2:4, pages 241-248.
Crossref
Hideyuki Yamada, Takahiko Baba, Kazuta Oguri & Hidetoshi Yoshimura. (1988) Enzymic reduction of N-hydroxyamphetamine: the role of electron transfer system containing cytochrome b5. Biochemical Pharmacology 37:2, pages 368-370.
Crossref
Takahiko Baba, Hideyuki Yamada, Kazuta Oguri & Hidetoshi Yoshimura. (1987) Studies on N-demethylation of methamphetamine by means of purified guinea-pig liver flavin-containing monooxygenase. Biochemical Pharmacology 36:23, pages 4171-4173.
Crossref
J.F. Brady, E.W. Di Stefano & A.K. Cho. (1986) Spectral and inhibitory interactions of (±)−3, 4-methylenedioxyamphetamine (MDA) and (±)−3, 4-methylenedioxymethampetamine (MDMA) with rat hepatic microsomes. Life Sciences 39:16, pages 1457-1464.
Crossref
Krys J. Miller, David C. Anderholm & Matthew M. Ames. (1986) Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations. Biochemical Pharmacology 35:10, pages 1737-1742.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.