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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 11
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Original Article

Metabolism of methamphetamine, amphetamine and p-hydroxymethamphetamine by rat-liver microsomal preparations in vitro

T. Yamamoto Department of Pharmacology, Medical College of Oita, 1-1506, Idaigaoka, Hazama-cho, Oita, 879-56, Japan
,
R. Takano Department of Pharmacology, Medical College of Oita, 1-1506, Idaigaoka, Hazama-cho, Oita, 879-56, Japan
,
T. Egashira Department of Pharmacology, Medical College of Oita, 1-1506, Idaigaoka, Hazama-cho, Oita, 879-56, Japan
&
Y. Yamanaka Department of Pharmacology, Medical College of Oita, 1-1506, Idaigaoka, Hazama-cho, Oita, 879-56, Japan
Pages 867-875 | Received 28 Jul 1983, Accepted 06 Mar 1984, Published online: 30 Sep 2009

Citations (16)

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John R. Richards, Colin G. Wang, Roderick W. Fontenette, Rory P. Stuart, Kerry F. McMahon & Samuel D. Turnipseed. (2020) Rhabdomyolysis, Methamphetamine, Amphetamine and MDMA Use: Associated Factors and Risks. Journal of Dual Diagnosis 16:4, pages 429-437.
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Mohammad Reza Eskandari, Mokhtar Rahmati, Ali Reza Khajeamiri, Farzad Kobarfard, Maryam Noubarani & Himan Heidari. (2014) A new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction. Xenobiotica 44:1, pages 70-76.
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Kenji Tsujikawa, Toshiyasu Mikuma, Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T. Iwata & Hiroyuki Inoue. (2011) Urinary excretion profiles of N-hydroxy-3,4-methylenedioxymethamphetamine in rats. Xenobiotica 41:7, pages 578-584.
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M.-A. Mori, M. Kobayashi, H. Uemura, Y. Mori, T. Miyahara & H. Kozuka. (1993) Metabolism of mephentermine and its derivatives by the microsomal fraction from male Wistar rat livers. Xenobiotica 23:1, pages 11-18.
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M.-A. Mori, M. Kobayashi, K. Sakai, K. Nakafuku, Y. Mori & H. Kozuka. (1992) The formation of metabolites of mephentermine by microsomal and cytosolic preparations of male Wistar rat livers. Xenobiotica 22:4, pages 451-457.
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T. Inoue & K. Tanaka. (1990) N-Oxidation and N-demethylation of methylephedrine by rat-liver microsomes. Xenobiotica 20:3, pages 265-271.
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T. Baba, H. Yamada, K. Oguri & H. Yoshimura. (1988) Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine. Xenobiotica 18:5, pages 475-484.
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H. Yamada, K. Oguri & H. Yoshimura. (1986) Effects of several factors on urinary excretion of methamphetamine and its metabolites in rats. Xenobiotica 16:2, pages 137-141.
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Articles from other publishers (8)

Christina Mullany, Paul A. Keller, Ari S. Nugraha & James F. Wallman. (2014) Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia. Forensic Science International 241, pages 102-111.
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M Mori, M Fujita & H Kozuka. (1985) The effect of phenothiazine and dibenzazepine pretreatment on the metabolism of methamphetamine in rats. Journal of Pharmacy and Pharmacology 37:11, pages 819-820.
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Sean C Gay, Arthur G Roberts & James R Halpert. (2010) Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR. Future Medicinal Chemistry 2:9, pages 1451-1468.
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M. Dostalek, E. Hadasova, M. Hanesova, J. Pistovcakova, A. Sulcova, J. Jurica, J. Tomandl & I. Linhart. (2005) Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats. European Journal of Drug Metabolism and Pharmacokinetics 30:3, pages 195-201.
Crossref
Chandrani Gunaratna & Peter T Kissinger. (1998) Investigation of stereoselective metabolism of amphetamine in rat liver microsomes by microdialysis and liquid chromatography with precolumn chiral derivatization. Journal of Chromatography A 828:1-2, pages 95-103.
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Charles V. Vorhees, Tracy M. Reed, Mary A. Schilling, J.Edward Fisher, Mary S. Moran, Gregg D. Cappon & Daniel W. Nebert. (1998) Cyp2d1 Polymorphism in Methamphetamine-Treated Rats. Neurotoxicology and Teratology 20:3, pages 265-273.
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Robert L. Fitzgerald, Robert V. Blanke & Alphonse Poklis. (2004) Stereoselective pharmacokinetics of 3,4‐methylenedioxymethamphetamine in the rat. Chirality 2:4, pages 241-248.
Crossref
Toshinori Yamamoto, Ritsuko Takano, Toru Egashira & Yasumitu Yamanaka. (1988) Reversible inhibition of aromatic hydroxylation of methamphetamine in rat liver microsomal preparations pretreated with methamphetamine. Biochemical Pharmacology 37:8, pages 1433-1437.
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