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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 5
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Original Article

Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes

M. Murray Institute for Comparative and Environmental Toxicology and Department of Entomology, Cornell University, Ithaca, NY, 14853, USA
,
Krystyna Hetnarski Institute for Comparative and Environmental Toxicology and Department of Entomology, Cornell University, Ithaca, NY, 14853, USA
&
C. F. Wilkinson Institute for Comparative and Environmental Toxicology and Department of Entomology, Cornell University, Ithaca, NY, 14853, USA
Pages 369-379 | Received 25 Apr 1984, Accepted 09 Oct 1984, Published online: 30 Sep 2009

Citations (32)

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Read on this site (6)

Michael Murray. (2016) CYP2J2 – regulation, function and polymorphism. Drug Metabolism Reviews 48:3, pages 351-368.
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Paul F. Hollenberg. (2002) Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes. Drug Metabolism Reviews 34:1-2, pages 17-35.
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M. Nakajima, M. Suzuki, R. Yamaji, H. Takashina, N. Shimada, H. Yamazaki & T. Yokoi. (1999) Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds. Xenobiotica 29:12, pages 1191-1202.
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David F. V. Lewis. (1997) Quantitative Structure-Activity Relationships in Substrates, Inducers, and Inhibitors of Cytochrome P4501 (CYP1). Drug Metabolism Reviews 29:3, pages 589-650.
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J. Petridou-fischer & A. Dahl. (1988) Inhibition of nasal and liver cytochrome P-450 mono-oxygenases by dioxolanes. Xenobiotica 18:1, pages 1-9.
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Marcel Mesnil, Bernard Testa & Peter Jenner. (1988) In vitro Inhibition by Stiripentol of Rat Brain Cytochrome P-450-Mediated Naphthalene Hydroxylation. Xenobiotica 18:9, pages 1097-1106.
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Articles from other publishers (26)

PAUL F. HOLLENBERG. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook 407 425 .
Pramod C. Nair, Tina B. Gillani, Tristan Rawling & Michael Murray. (2021) Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chemico-Biological Interactions 338, pages 109401.
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Michael Murray, Wei V. Zhang & Robert J. Edwards. (2018) Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. Basic & Clinical Pharmacology & Toxicology 122:4, pages 388-395.
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Michael Murray, Tina B. Gillani, Sussan Ghassabian, Robert J. Edwards & Tristan Rawling. (2018) Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver. European Journal of Pharmaceutical Sciences 114, pages 55-63.
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Kaori Yasuda, Sera Ueno, Erika Ueda, Miyu Nishikawa, Kie Takeda, Masaki Kamakura, Shinichi Ikushiro & Toshiyuki Sakaki. (2015) Influence of sesamin on CYP 2C‐mediated diclofenac metabolism: in vitro and in vivo analysis . Pharmacology Research & Perspectives 3:5.
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Maria Almira Correia & Paul. F. Hollenberg. 2015. Cytochrome P450. Cytochrome P450 177 259 .
Suvi T. M. Orr, Sharon L. Ripp, T. Eric Ballard, Jaclyn L. Henderson, Dennis O. Scott, R. Scott Obach, Hao Sun & Amit S. Kalgutkar. (2012) Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks. Journal of Medicinal Chemistry 55:11, pages 4896-4933.
Crossref
Paul F. Hollenberg. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 18 .
Paul F. Hollenberg. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 341 358 .
John S. Walsh. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery 49 80 .
Gérard Simonneaux & Paul Le Maux. 2006. Bioorganometallic Chemistry. Bioorganometallic Chemistry 83 122 .
Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
GÉRARD SIMONNEAUX & PAUL LE MAUX. 2003. The Porphyrin Handbook. The Porphyrin Handbook 133 159 .
Masato Chiba, Joy A Nishime, I-Wu Chen, Kari J Vastag, Yousif S Sahly, Byeong Moon Kim, Bruce D Dorsey, Joseph P Vacca & Jiunn H Lin. (1998) Metabolite–P450 Complex Formation by Methylenedioxyphenyl HIV Protease Inhibitors in Rat and Human Liver Microsomes. Biochemical Pharmacology 56:2, pages 223-230.
Crossref
Jiunn H. Lin & Anthony Y.H. Lu. 1997. 295 304 .
David F.V. Lewis, Costas Ioannides & Dennis V. Parke. (1995) Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501. Toxicology Letters 76:1, pages 39-45.
Crossref
Paul R. Ortiz de Montellano & Maria Almira Correia. 1995. Cytochrome P450. Cytochrome P450 305 364 .
Michael Murray & Ishita Mehta. (1990) Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17-dione hydroxylase activities by derivatives of 5α- and 5β-androstane. Journal of Steroid Biochemistry 35:3-4, pages 465-471.
Crossref
Marcel Mesnil, Bernard Testa & Peter Jenner. (1988) Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol. Biochemical Pharmacology 37:19, pages 3619-3622.
Crossref
David A. Erickson, Mark S. Goodrich & John J. Lech. (1988) The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri). Toxicology and Applied Pharmacology 94:1, pages 1-10.
Crossref
Michael Murray. (1988) Complexation of cytochrome P-450 isozymes in hepatic microsomes from SKF 525-A-induced rats. Archives of Biochemistry and Biophysics 262:1, pages 381-388.
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Lee A. Morehouse & Steven D. Aust. 1988. Oxygen Radicals in Biology and Medicine. Oxygen Radicals in Biology and Medicine 517 521 .
Michael Murray. (1987) New heterocyclic modifiers of oxidative drug metabolism—II. Biochemical Pharmacology 36:4, pages 463-468.
Crossref
Michael Murray, Louise Zaluzny & Geoffrey C. Farrell. (1986) Selective reactivation of steroid hydroxylases following dissociation of the isosafrole metabolite complex with rat hepatic cytochrome P-450. Archives of Biochemistry and Biophysics 251:2, pages 471-478.
Crossref
Michael Murray & Geoffrey C. Farrell. (1986) Mechanistic aspects of the inhibition of microsomal drug oxidation by primaquine. Biochemical Pharmacology 35:13, pages 2149-2155.
Crossref
Michael Murray, Ernest Lacey & Geoffrey C. Farrell. (1986) New heterocyclic modifiers of oxidative drug metabolism—I. Biochemical Pharmacology 35:12, pages 1971-1979.
Crossref

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