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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 6
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Original Article

4,5-Dimethylthiazole-N-oxide-S-oxide: A metabolite of chlormethiazole in man

C. P. Offen School of Natural Sciences, The Hatfield Polytechnic, Hatfield, Hertfordshire, UK
,
M. J. Frearson School of Natural Sciences, The Hatfield Polytechnic, Hatfield, Hertfordshire, UK
,
K. Wilson School of Natural Sciences, The Hatfield Polytechnic, Hatfield, Hertfordshire, UK
&
D. Burnett Clinical Biochemistry Department, City Hospital, St Albans, Hertfordshire, UK
Pages 503-511 | Received 12 Jul 1984, Published online: 30 Sep 2009

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X. Yang & W. Chen. (2005) In vitro microsomal metabolic studies on a selective mGluR5 antagonist MTEP: Characterization of in vitro metabolites and identification of a novel thiazole ring opening aldehyde metabolite. Xenobiotica 35:8, pages 797-809.
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K. Wilson, H. Chissick, A. M. Fowler, F. J. Frearson, M. Gittins & F. J. Swinbourne. (1991) Metabolism of benzothiazole. I. Identification of ring-cleavage products. Xenobiotica 21:9, pages 1179-1183.
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Articles from other publishers (13)

Chaitanya K. Jaladanki, Samima Khatun, Holger Gohlke & Prasad V. Bharatam. (2021) Reactive Metabolites from Thiazole-Containing Drugs: Quantum Chemical Insights into Biotransformation and Toxicity. Chemical Research in Toxicology 34:6, pages 1503-1517.
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Disha Thakkar & Abhijeet S. Kate. (2019) In silico , in vitro and in vivo metabolite identification of brexpiprazole using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry . Rapid Communications in Mass Spectrometry 33:11, pages 1024-1035.
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Gunnar Hall, Susanne Alenljung & Ulla Forsgren-Brusk. (2017) Identification of Key Odorants in Used Disposable Absorbent Incontinence Products. Journal of Wound, Ostomy & Continence Nursing 44:3, pages 269-276.
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. (2015) Scientific Opinion on Flavouring Group Evaluation 21, Revision 5 (FGE.21Rev5): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 13:4.
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. (2013) Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 11:11.
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. (2012) Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 10:2, pages 2457.
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. (2011) Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. EFSA Journal 9:10, pages 1989.
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. (2009) Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30. EFSA Journal 7:8.
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. (2008) Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) ‐ Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:3.
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Amit S. Kalgutkar, James Driscoll, Sabrina X. Zhao, Gregory S. Walker, Richard M. Shepard, John R. Soglia, James Atherton, Linning Yu, Abdul E. Mutlib, Michael J. Munchhof, Lawrence A. Reiter, Christopher S. Jones, Johnathan L. Doty, Kristen A. Trevena, Christopher L. Shaffer & Sharon L. Ripp. (2007) A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif. Chemical Research in Toxicology 20:12, pages 1954-1965.
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M. J. Wilby & P. J. Hutchinson. (2006) The Pharmacology of Chlormethiazole: A Potential Neuroprotective Agent?. CNS Drug Reviews 10:4, pages 281-294.
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Deepak K. Dalvie & Thomas N. O'Connell. (2004) CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES. Drug Metabolism and Disposition 32:1, pages 49-57.
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A. L. Burlingame, Thomas A. Baillie & Peter J. Derrick. (2002) Mass spectrometry. Analytical Chemistry 58:5, pages 165-211.
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