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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 11
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Original Article

Metabolism and enterohepatic circulation of benzo(a)pyrene-4,5-epoxide in the rat

T. R. D. Elmhirst Department of Biochemistry, St Mary's Hospital Medical School, London, W2 1PG, UK
,
J. K. Chipman Department of Biochemistry, St Mary's Hospital Medical School, London, W2 1PG, UK
,
O. Ribeiro Department of Biochemistry, St Mary's Hospital Medical School, London, W2 1PG, UK
,
P. C. Hirom Department of Biochemistry, St Mary's Hospital Medical School, London, W2 1PG, UK
&
P. Millburn Department of Biochemistry, St Mary's Hospital Medical School, London, W2 1PG, UK
Pages 899-906 | Received 02 Dec 1984, Published online: 30 Sep 2009

Citations (13)

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Marjory Moreau, Pierre Ayotte & Michèle Bouchard. (2015) Kinetics of Diol and Hydroxybenzo[a]pyrene Metabolites in Relation to DNA Adduct Formation and Gene Expression in Rats. Journal of Toxicology and Environmental Health, Part A 78:12, pages 725-746.
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Articles from other publishers (12)

Marjory Moreau & Michèle Bouchard. (2015) Comparison of the kinetics of various biomarkers of benzo[ a ]pyrene exposure following different routes of entry in rats . Journal of Applied Toxicology 35:7, pages 781-790.
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Yu Gao, Jingwei Shao, Zhou Jiang, Jianzhong Chen, Songen Gu, Suhong Yu, Ke Zheng & Lee Jia. (2014) Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19:3, pages 326-340.
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Sang-K. Noh & Ju-Yeon Kim. (2011) Enteral Infusion of Green Tea Extract Selectively Enhances the Biliary Secretion of 14 C-Benzo[a]pyrene in Rats without Affecting Other Biliary Lipids . Preventive Nutrition and Food Science 16:2, pages 104-109.
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Aramandla Ramesh, Stormy A. Walker, Darryl B. Hood, Maria D. Guillén, Klaus Schneider & Eric H. Weyand. (2016) Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons. International Journal of Toxicology 23:5, pages 301-333.
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Theo M.C.M de Kok & Jan M.S van Maanen. (2000) Evaluation of fecal mutagenicity and colorectal cancer risk. Mutation Research/Reviews in Mutation Research 463:1, pages 53-101.
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K KataokaT KinouchiS AkimotoY Ohnishi. (1995) Bioactivation of cysteine conjugates of 1-nitropyrene oxides by cysteine conjugate beta-lyase purified from Peptostreptococcus magnus. Applied and Environmental Microbiology 61:11, pages 3781-3787.
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Yang Yang, Börje Egestad, Bengt Jernström, Jan Sjöovall, Jan‐Åke Gustafsson, Joseph Rafter & T. A. Bailli. (2005) Dynamic fast‐atom bombardment mass spectrometry of conjugated metabolites of benzo[ a ]pyrene . Rapid Communications in Mass Spectrometry 5:11, pages 499-502.
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Gary M. Pollack & Kim L. R. Brouwer. (1991) Physiologic and metabolic influences on enterohepatic recirculation: Simulations based upon the disposition of valproic acid in the rat. Journal of Pharmacokinetics and Biopharmaceutics 19:2, pages 189-225.
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G.L. LARSEN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 79 107 .
Leslie Recio & Abraham W. Hsie. (1987) Modulation of the cytotoxicity and mutagenicity of benzo[a]pyrene and benzo[a]pyrene 7,8-diol by glutathione and glutathione S-transferases in mammalian cells (CHO/HGPRT assay). Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 178:2, pages 257-269.
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Börje Egestad, Per Pettersson, Jan Sjövall, Joseph Rafter, Kaija Hyvönen & Jan‐Åke Gustafsson. (2005) Studies on the chromatographic fractionation of metabolites of benzo[ a ]pyrene in faeces and urine from germfree and conventional rats . Biomedical Chromatography 2:3, pages 120-134.
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O. Ribeiro, C. A. Kirkby, P. C. Hirom & P. Millburn. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 833 842 .

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