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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 11
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Original Article

Formation of reactive metabolites of phenacetin in humans and rats

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Pages 929-940 | Received 14 Sep 1984, Published online: 30 Sep 2009

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P. David Josephy. (2005) The Molecular Toxicology of Acetaminophen. Drug Metabolism Reviews 37:4, pages 581-594.
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James E. Hines III, Curtistine J. Deere, Poornasai Vaddi, Ranjeeth R. Kondati, Frank R. Fronczek & Rao M. Uppu. (2022) N -(4-Methoxy-2-nitrophenyl)acetamide . IUCrData 7:3.
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Yasushi Yamazoe & Kunitoshi Mitsumori. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 171 192 .
Yuki Kobayashi, Tatsuki Fukami, Ryota Higuchi, Miki Nakajima & Tsuyoshi Yokoi. (2012) Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. Biochemical Pharmacology 84:9, pages 1196-1206.
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Alexander V. LyubimovHayley M. Webb, Sophie Regan, Daniel J. Antoine, Nicola Lane, Rachel J. Walsh, Abhishek Srivastava, Philip Starkey‐Lewis, Craig Benson, Dominic P. Williams, Hugh Laverty, Christopher Goldring & B. Kevin Park. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 44 .
Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J. Elliot, Kushari Bowalgaha, Kathleen M. Knights & John O. Miners. (2012) Effect of Albumin on Human Liver Microsomal and Recombinant CYP1A2 Activities: Impact on In Vitro-In Vivo Extrapolation of Drug Clearance. Drug Metabolism and Disposition 40:5, pages 982-989.
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Graham F. Smith. 2011. Progress in Medicinal Chemistry Volume 50. Progress in Medicinal Chemistry Volume 50 1 47 .
K. Mathijs, K. J. J. Brauers, D. G. J. Jennen, D. Lizarraga, J. C. S. Kleinjans & J. H. M. van Delft. (2010) Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds. Mutagenesis 25:6, pages 561-568.
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Donald J. AbrahamJulian Blagg. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 301 334 .
Abhishek Srivastava, Lu-Yun Lian, James L. Maggs, Masautso Chaponda, Munir Pirmohamed, Dominic P. Williams & B. Kevin Park. (2010) Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. Drug Metabolism and Disposition 38:1, pages 122-132.
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Li Liu, Carston R. Wagner & Patrick E. Hanna. (2009) Isoform-Selective Inactivation of Human Arylamine N -Acetyltransferases by Reactive Metabolites of Carcinogenic Arylamines . Chemical Research in Toxicology 22:12, pages 1962-1974.
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Lijuan Zhang, Xiaoqun Mu, Juanling Fu & Zongcan Zhou. (2007) In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney. Toxicology in Vitro 21:4, pages 734-740.
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Sundeep S. Dhareshwar & Valentino J. Stella. 2007. Prodrugs. Prodrugs 731 799 .
Nagako Tanaka, Taku Miyasho, Raku Shinkyo, Toshiyuki Sakaki & Hiroshi Yokota. (2006) cDNA cloning and characterization of feline CYP1A1 and CYP1A2. Life Sciences 79:26, pages 2463-2473.
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Paul R. Ortiz de Montellano & James J. De Voss. 2005. Cytochrome P450. Cytochrome P450 183 245 .
Paul R. Ortiz de Montellano. 1995. Cytochrome P450. Cytochrome P450 245 303 .
L. M. H. Koymans, W. M. P. B. Menge, G. M. Donné‐Op Den Kelder, J. M. Te Koppele, N. P. E. Vermeulen & J. H. van Lenthe. (2010) A theoretical study on the oxidative metabolism of 4‐chloroacetanilide by cytochrome P450: Alternative mechanisms for migration of 4‐substituents during enzymatic oxidation. Recueil des Travaux Chimiques des Pays-Bas 112:2, pages 186-190.
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D.J. Kirkland, J.H. Dresp, R.R. Marshall, M. Baumeister, C. Gerloff & E. Gocke. (1992) Normal chromosomal aberration frequencies in peripheral lymphocytes of healthy human volunteers exposed to a maximum daily dose of paracetamol in a double blind trial. Mutation Research/Genetic Toxicology 279:3, pages 181-194.
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Charles B. Jensen & David J. Jollow. (1991) The role of N-hydroxyphenetidine in phenacetin-induced hemolytic anemia. Toxicology and Applied Pharmacology 111:1, pages 1-12.
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M. E. Veronese & S. McLean. (1991) Metabolism of paracetamol and phenacetin in relation to debrisoquine oxidation phenotype. European Journal of Clinical Pharmacology 40:6, pages 547-552.
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J. Topinka, R.J. Šrám, G. Širinjan, J. Kočišová, B. Binková & I. Fojtíková. (1989) Mutagenicity studies on paracetamol in human volunteers II. Unscheduled DNA synthesis and micronucleus test. Mutation Research Letters 227:3, pages 147-152.
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