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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 2
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Research Article

Dose-dependent elimination of theophylline in rats

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Pages 165-171 | Received 05 Dec 1983, Accepted 30 Aug 1984, Published online: 22 Sep 2008

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João Monteiro, Marco G. Alves, Pedro F. Oliveira & Branca M. Silva. (2019) Pharmacological potential of methylxanthines: Retrospective analysis and future expectations. Critical Reviews in Food Science and Nutrition 59:16, pages 2597-2625.
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Flavio Gaspari & Maurizio Bonati. (1990) Interspecies Metabolism and Pharmacokinetic Scaling of Theophylline Disposition. Drug Metabolism Reviews 22:2-3, pages 179-207.
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Miyoko Matsushima, Souma Tanihata, Junpei Kusakabe, Momoha Okahira, Hiroshi Ito, Atsushi Yamamoto, Masanori Yamamoto, Ryohei Yamamoto & Tsutomu Kawabe. (2022) Correlation of theophylline levels in rat exhaled breath and lung tissue after its intravenous injection. Journal of Breath Research 16:3, pages 036003.
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Yoo-Seong Jeong, Chang-Soon Yim, Heon-Min Ryu, Chi-Kyoung Noh, Yoo-Kyung Song & Suk-Jae Chung. (2017) Estimation of the minimum permeability coefficient in rats for perfusion-limited tissue distribution in whole-body physiologically-based pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics 115, pages 1-17.
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Jung-woo Chae, In-hwan Baek & Kwang-il Kwon. (2012) Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats. Journal of Ethnopharmacology 144:2, pages 248-254.
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Jung-woo Chae, Jung-hwa An, Wonku Kang, Jin yeul Ma & Kwang-il Kwon. (2012) Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. Food and Chemical Toxicology 50:10, pages 3666-3672.
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Jung-woo Chae, Dong-hyun Kim, Byung-yo Lee, Eun jung Kim & Kwang-il Kwon. (2012) Development and validation of a sensitive LC–MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of Chromatography B 889-890, pages 44-49.
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Denise Poisson, Antoine Dupuis, Michel Breteau, Serge Bouquet, Marc Poterre & William Couet. (1997) Effect of Tamoxifen on the Pharmacokinetics of Theophylline in Rats. Journal of Pharmacy and Pharmacology 49:1, pages 40-42.
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Ruttikorn Apichartpichean, Takaaki Hasegawa, Masayuki Nadai, Takafumi Kuzuya & Toshitaka Nabeshima. (1991) Structure-pharmacokinetic Relationships among the N 1, N 3-Alkylxanthines in Rats . Journal of Pharmacy and Pharmacology 43:4, pages 262-269.
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Xian Pan, Ping Wang, Nan Hu, Li Liu, Xiaodong Liu, Lin Xie & Guangji Wang. (2011) A Physiologically Based Pharmacokinetic Model Characterizing Mechanism-based Inhibition of CYP1A2 for Predicting Theophylline/Antofloxacin Interaction in both Rats and Humans. Drug Metabolism and Pharmacokinetics 26:4, pages 387-398.
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Bertil B. FredholmMaurice J. Arnaud. 2011. Methylxanthines. Methylxanthines 33 91 .
Chao-Feng Chien, Yu-Tse Wu, Wen-Chuan Lee, Lie-Chwen Lin & Tung-Hu Tsai. (2010) Herb–drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chemico-Biological Interactions 184:3, pages 458-465.
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Kyung H Yang, Joo H Lee & Myung G Lee. (2008) Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. Journal of Pharmacy and Pharmacology 60:1, pages 45-53.
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Yune-Fang UengTung-Hu TsaiMing-Jaw DonRuei-Ming ChenTa-Liang Chen. (2005) Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa , in rats . Journal of Pharmacy and Pharmacology 57:2, pages 227-232.
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Su Yeon Yu, Hye Chin Chung, Eun Jung Kim, So Hee Kim, Inchull Lee, Sang Geon Kim & Myung Gull Lee. (2002) Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. Journal of Pharmacy and Pharmacology 54:12, pages 1687-1692.
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Yune-Fang Ueng, Ching-Chin Tsai, Wei-Sheng Lo & Chul-Ho Yun. (2010) Induction of Hepatic Cytochrome P450s by the Herbal Medicine Sophora flavescens Extract in Rats: Impact on the Elimination of Theophylline. Drug Metabolism and Pharmacokinetics 25:6, pages 560-567.
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Kyung H. Yang, Young S. Jung, Dae Y. Lee, Joo H. Lee, Young C. Kim & Myung G. Lee. (2008) Time-Dependent Effects of Klebsiella Pneumoniae Endotoxin (KPLPS) on the Pharmacokinetics of Theophylline in Rats: Return of the Parameters in 96-Hour KPLPS Rats to the Control Levels . Drug Metabolism and Disposition 36:5, pages 811-815.
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Jingling Tang, Jin Sun, Yongqiang Zhang, Lin Li, Fude Cui & Zhonggui He. (2007) Herb–drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats. Food and Chemical Toxicology 45:12, pages 2441-2445.
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Hye D. Choi, Hee E. Kang, Hye J. Chung, Soo K. Bae, Karen N. Shin & Myung G. Lee. (2007) Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3‐dimethyluric acid, after intravenous and oral administration of aminophylline to rats. Biopharmaceutics & Drug Disposition 28:8, pages 445-454.
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Soo K. Bae, Hee E. Kang, Min K. Kang, Jin W. Kim, Taekrho Kim & Myung G. Lee. (2006) Pharmacokinetics of Oltipraz in Mutant Nagase Analbuminemic Rats. Journal of Pharmaceutical Sciences 95:5, pages 998-1005.
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Woan-Ching Jan, Lie-Chwen Lin, Chieh-Fu-Chen & Tung-Hu Tsai. (2005) Herb–drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats. Journal of Ethnopharmacology 102:3, pages 440-445.
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Yu Chul Kim, Ae Kyung Lee, Joo Hyun Lee, Inchul Lee, Duk Chul Lee, So Hee Kim, Sang Geon Kim & Myung Gull Lee. (2005) Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European Journal of Pharmaceutical Sciences 26:1, pages 114-123.
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Sandrine Derkenne, Christine P. Curran, Howard G. Shertzer, Timothy P. Dalton, Nadine Dragin & Daniel W. Nebert. (2005) Theophylline pharmacokinetics: comparison of Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenetics and Genomics 15:7, pages 503-511.
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Makiko Kizawa, Etsuko Miyamoto, Shuka Aono, Junichi Kawakami & Isao Adachi. (2005) Inhibition of Theophylline Metabolism by Suplatast and Its Metabolites in Rats. Biological and Pharmaceutical Bulletin 28:6, pages 1061-1065.
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Tung-Hu Tsai & Mei-Chun Liu. (2004) Determination of unbound theophylline in rat blood and brain by microdialysis and liquid chromatography. Journal of Chromatography A 1032:1-2, pages 97-101.
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Eun Jung Kim, Ok Kyung Suh & Myung Gull Lee. (2003) Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. Life Sciences 72:11, pages 1231-1245.
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K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food and Chemical Toxicology 39:7, pages 667-680.
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Pascal L. Hickey, Peter W. Angus, Allan J. Mclean & Denis J. Morgan. (1995) Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats. Gastroenterology 108:5, pages 1504-1509.
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R.A.A. Mathoˆt, S. Appel, E.A. van Schaick, W. Soudijn, A.P. Ijzerman & M. Danhof. (1993) High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats. Journal of Chromatography B: Biomedical Sciences and Applications 620:1, pages 113-120.
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C. INGVAST‐LARSSON, L.‐E. APPELGREN & G. NYMAN. (2008) Distribution studies of theophylline: microdialysis in rat and horse and whole body autoradiography in rat. Journal of Veterinary Pharmacology and Therapeutics 15:4, pages 386-394.
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Masayuki Nadai, Takaaki Hasegawa, Isao Muraoka, Kenzo Takagi & Toshitaka Nabeshima. (1991) Dose-Dependent Pharmacokinetics of Enprofylline and Its Renal Handling in Rats. Journal of Pharmaceutical Sciences 80:7, pages 648-652.
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K TakagiK YamakiM NadaiT KuzuyaT Hasegawa. (1991) Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients. Antimicrobial Agents and Chemotherapy 35:6, pages 1137-1141.
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Lars Ståhle. 1991. Microdialysis in the Neurosciences. Microdialysis in the Neurosciences 155 174 .
Lars Ståhle, Stina Segersvärd & Urban Ungerstedt. (1991) Drug distribution studies with microdialysis II. Caffeine and theophylline in blood, brain and other tissues in rats. Life Sciences 49:24, pages 1843-1852.
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Kathleen H. Anderson, Paul J. Perry, Arnold D. Sherman & Roger G. Kathol. (1989) Behavioral performance and seizure activity of lithium-intoxicated Sprague-Dawley rats treated with theophylline. Psychiatry Research 30:1, pages 77-82.
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Gerard J. Mulder, J.Fred Nagelkerke, Roeline B. Tijdens, Wilhelmus J.A. Wijnands & Ed J. Van Der Mark. (1988) Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin. Biochemical Pharmacology 37:13, pages 2565-2568.
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E. J. van Hoogdalem, A. G. De Boer & D. D. Breimer. (1986) Influence of salicylate and anaesthesia on the rectal absorption of theophylline in rats. Pharmaceutisch Weekblad 8:6, pages 281-285.
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