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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 3
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Original Article

trans, trans-Muconic acid, an open-chain urinary metabolite of benzene in mice. Quantification by high-pressure liquid chromatography

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Pages 211-220 | Received 10 Apr 1984, Published online: 30 Sep 2009

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Anthony P. DeCaprio. (1999) The Toxicology of Hydroquinone — Relevance to Occupational and Environmental Exposure. Critical Reviews in Toxicology 29:3, pages 283-330.
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A. M. Medeiros, M. G. Bird & G. Witz. (1997) POTENTIAL BIOMARKERS OF BENZENE EXPOSURE. Journal of Toxicology and Environmental Health 51:6, pages 519-539.
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Sergio Ghittori, Luciano Maestri, Laura Rolandi, Lorenzo Lodola, Maria Lorena Fiorentino & Marcello Imbriani. (1996) The Determination of Trans, Trans-Muconic Acid in Urine as an Indicator of Occupational Exposure to Benzene. Applied Occupational and Environmental Hygiene 11:3, pages 187-192.
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F. Bosch Reig, P. Campíns Falcó & J. Verdü Andrés. (1995) Preconcentration, Sample Clean-Up, and HPLC Determination of Phenol and its Chloro, Methyl, and Nitro Derivatives in Biological Samples. A Review. Journal of Liquid Chromatography 18:11, pages 2229-2241.
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Andi Bartczak, StanleyA. Kline, Ryun Yu, CliffordP. Weisel, BernardD. Goldstein, Gisela Witz & WilliamE. Bechtold. (1994) Evaluation of assays for the identification and quantitation of muconic acid, a benzene metabolite in human urine. Journal of Toxicology and Environmental Health 42:3, pages 245-258.
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Articles from other publishers (42)

Sean M. Hays, David W. Pyatt, Chris R. Kirman & Lesa L. Aylward. (2012) Biomonitoring Equivalents for benzene. Regulatory Toxicology and Pharmacology 62:1, pages 62-73.
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Benjamin Smith, Peter Cadby, Michael DiNovi & R. Woodrow Setzer. (2010) Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology 48, pages S49-S56.
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S Wilbur, D Wohlers, S Paikoff, LS Keith & O Faroon. (2008) ATSDR evaluation of potential for human exposure to benzene. Toxicology and Industrial Health 24:5-6, pages 399-442.
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S Wilbur, D Wohlers, S Paikoff, LS Keith & O Faroon. (2008) ATSDR evaluation of health effects of benzene and relevance to public health. Toxicology and Industrial Health 24:5-6, pages 263-398.
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Assieh A. Melikian, Qingshan Qu, Roy Shore, Guilan Li, Heyi Li, Ximei Jin, Beverly Cohen, Lungchi Chen, Yuying Li, Songnian Yin, Reidong Mu, Xiaoling Zhang & Yuanxiang Wang. (2002) Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid. Journal of Chromatography B 778:1-2, pages 211-221.
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Giorgio Marrubini, Teresa Coccini & Luigi Manzo. (2001) Direct analysis of urinary trans,trans-muconic acid by coupled column liquid chromatography and spectrophotometric ultraviolet detection: method applicability to human urine. Journal of Chromatography B: Biomedical Sciences and Applications 758:2, pages 295-303.
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Thomas Renner, Michaela Baer-Koetzle & Gerhard Scherer. (1999) Determination of sorbic acid in urine by gas chromatography–mass spectrometry. Journal of Chromatography A 847:1-2, pages 127-133.
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Assieh A. Melikian, Ray O'Connor, Agasanur K. Prahalad, Peifeng Hu, Heyi Li, Mark Kagan & Seth Thompson. (1999) Determination of the urinary benzene metabolites S-phenylmercapturic acid and trans,trans-muconic acid by liquid chromatography-tandem mass spectrometry. Carcinogenesis 20:4, pages 719-726.
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Gerhard Scherer, Thomas Renner & Michael Meger. (1998) Analysis and evaluation of trans,trans-muconic acid as a biomarker for benzene exposure. Journal of Chromatography B: Biomedical Sciences and Applications 717:1-2, pages 179-199.
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F. Gobba, S. Rovesti, P. Borella, R. Vivoli, E. Caselgrandi & G. Vivoli. (1997) Inter-individual variability of benzene metabolism to trans,trans-muconic acid and its implications in the biological monitoring of occupational exposure. Science of The Total Environment 199:1-2, pages 41-48.
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Jingsheng Tuo, Steffen Loft, Mikael S. Thomsen & Henrik E. Poulsen. (1996) Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition. Mutation Research/Genetic Toxicology 368:3-4, pages 213-219.
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Nimmagudda R. Rao & Robert Snyder. (2006) Oxidative modifications produced in HL‐60 cells on exposure to benzene metabolites. Journal of Applied Toxicology 15:5, pages 403-409.
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Sergio Ghittori, Luciano Maestri, Maria Lorena Fiorentino & Marcello Imbriani. (1995) Evaluation of occupational exposure to benzene by urinalysis. International Archives of Occupational and Environmental Health 67:3, pages 195-200.
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Thomas Ruppert, Gerhard Scherer, Anthony R. Tricker, Dankwart Rauscher & Franz Adlkofer. (1995) Determination of urinary trans,trans-muconic acid by gas chromatography-mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 666:1, pages 71-76.
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Choon-Nam Ong & Bee-Lan Lee. (1994) Determination of benzene and its metabolites: Application in biological monitoring of environmental and occupational exposure to benzene. Journal of Chromatography B: Biomedical Sciences and Applications 660:1, pages 1-22.
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Wagida A. Anwar. (1994) Praziquantel (antischistosomal drug): is it clastogenic, co-clastogenic or anticlastogenic?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 305:2, pages 165-173.
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V.Lee Grotz, Ji Sungchul, Stanley A. Kline, Bernard D. Goldstein & Gisela Witz. (1994) Metabolism of benzene and trans, trans-muconaldehyde in the isolated perfused rat liver. Toxicology Letters 70:3, pages 281-290.
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F. Sch?fer, H. Schad & L. Weber. (1993) Determination of phenylmercapturic acid in urine of benzene-exposed BDF-1 mice. Journal of Chromatography B: Biomedical Sciences and Applications 620:2, pages 239-242.
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Daniel Goon, James Matsuura & David Ross. (1993) Metabolism and cytotoxicity of trans,trans-Muconaldehyde and its derivatives: Potential markers of benzene ring cleavage reactions. Chemico-Biological Interactions 88:1, pages 37-53.
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R SnyderG WitzB D Goldstein. (1993) The toxicology of benzene.. Environmental Health Perspectives 100, pages 293-306.
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P. Ducos, R. Gaudin, J. Bel, C. Maire, J. M. Francin, A. Robert & P. Wild. (1992) trans,trans-Muconic acid, a reliable biological indicator for the detection of individual benzene exposure down to the ppm level. International Archives of Occupational and Environmental Health 64:5, pages 309-313.
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Jürgen Angerer & Brigitte Hörsch. (1992) Determination of aromatic hydrocarbons and their metabolites in human blood and urine. Journal of Chromatography B: Biomedical Sciences and Applications 580:1-2, pages 229-255.
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Daniel Goon, Xiaoqin Cheng, James A. Ruth, Dennis R. Petersen & David Ross. (1992) Metabolism of trans, trans-muconaldehyde by aldehyde and alcohol dehydrogenases: Identification of a novel metabolite. Toxicology and Applied Pharmacology 114:1, pages 147-155.
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Harald Schad, Freya Sch?fer, Lothar Weber & Hans Joachim Seidel. (1992) Determination of benzene metabolites in urine of mice by solid-phase extraction and high-performance liquid chromatography. Journal of Chromatography A 593:1-2, pages 147-151.
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Moire L. Robertson, David A. Eastmond & Martyn T. Smith. (1991) Two benzene metabolites, catechol and hydroquinone, produce a synergistic induction of micronuclei and toxicity in cultured human lymphocytes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 249:1, pages 201-209.
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G. Witz, T. A. Kirley, W. M. Maniara, V. J. Mylavarapu & B. D. Goldstein. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 613 618 .
P. Ducos, R. Gaudin, A. Robert, J. M. Francin & C. Maire. (1990) Improvement in HPLC analysis of urinary trans, trans-muconic acid, a promising substitute for phenol in the assessment of benzene exposure. International Archives of Occupational and Environmental Health 62:7, pages 529-534.
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Gisela Witz, Wieslawa Maniara, Vijaya Mylavarapu & Bernard D. Goldstein. (1990) Comparative metabolism of benzene and trans,trans-muconaldehyde to trans,trans-muconic acid in DBA/2N and C57BL/6 MICE. Biochemical Pharmacology 40:6, pages 1275-1280.
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M T SmithJ W YagerK L SteinmetzD A Eastmond. (1989) Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity.. Environmental Health Perspectives 82, pages 23-29.
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G WitzL LatrianoB D Goldstein. (1989) Metabolism and toxicity of trans,trans-muconaldehyde, an open-ring microsomal metabolite of benzene.. Environmental Health Perspectives 82, pages 19-22.
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Stanley Seltzer & Jennifer Hane. (1988) Maleylacetoacetate cis-trans isomerase: One-step double cis-trans isomerization of monomethyl muconate and the enzyme's probable role in benzene metabolism. Bioorganic Chemistry 16:4, pages 394-407.
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Patrick J. Sabourin, William E. Bechtold, Linda S. Birnbaum, George Lucier & Rogene F. Henderson. (1988) Differences in the metabolism and disposition of inhaled [3H]benzene by F344N rats and B6C3F1 mice. Toxicology and Applied Pharmacology 94:1, pages 128-140.
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Patrick J. Sabourin, William E. Bechtold & Rogene F. Henderson. (1988) A high pressure liquid chromatographic method for the separation and quantitation of water-soluble radiolabeled benzene metabolites. Analytical Biochemistry 170:2, pages 316-327.
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Mohy Morris Gad-El Karim, V.M. Sadagopa Ramanujam & Marvin S. Legator. (1986) Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice. Toxicology and Applied Pharmacology 85:3, pages 464-477.
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