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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 4
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Research Article

Phenolic metabolites of thioridazine in man

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Pages 309-316 | Received 14 May 1984, Published online: 22 Sep 2008

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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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B. L. Blake, R. L. Rose, R. B. Mailman, P. E. Levi & E. Hodgson. (1995) Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase. Xenobiotica 25:4, pages 377-393.
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G. Lin, E. M. Hawes, G. McKay, E. D. Korchinski & K. K. Midha. (1993) Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat. Xenobiotica 23:10, pages 1059-1074.
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G. Lin, E. M. Hawes, G. McKay, E. D. Korchinski & K. K. Midha. (1993) The metabolism of piperidine-type phenothiazine antipsychotic agents. III. Mescridazine in dog, human and rat. Xenobiotica 23:1, pages 37-52.
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G. Lin, E. M. Hawes, G. McKay, S. F. Cooper, E. D. Korchinski & K. K. Midha. (1993) The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human. Xenobiotica 23:1, pages 27-36.
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G. Lin, E. M. Hawes, G. McKay & K. K. Midha. (1992) The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat. Xenobiotica 22:3, pages 303-317.
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A. S. Papadopoulos & J. L. Crammer. (1986) Sulphoxide metabolites of thioridazine in man. Xenobiotica 16:12, pages 1097-1107.
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Articles from other publishers (16)

Myung Joo KANG, Woo Heon SONG, Byung Ho SHIM, Seung Youn OH, Hyun Young LEE, Eun Young CHUNG, Yesung SOHN & Jaehwi LEE. (2010) Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development. YAKUGAKU ZASSHI 130:10, pages 1325-1337.
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Bo Wen & Mingyan Zhou. (2009) Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s. Chemico-Biological Interactions 181:2, pages 220-226.
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Jacek Wójcikowski, Patrick Maurel & Władysława A. Daniel. (2006) CHARACTERIZATION OF HUMAN CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF THE PIPERIDINE-TYPE PHENOTHIAZINE NEUROLEPTIC THIORIDAZINE. Drug Metabolism and Disposition 34:3, pages 471-476.
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Steven M. Toler. (2016) Oxidative Stress Plays an Important Role in the Pathogenesis of Drug-Induced Retinopathy. Experimental Biology and Medicine 229:7, pages 607-615.
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Donald J. AbrahamC. Anthony Altar, Arnold R. Martin & Andrew Thurkauf. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 599 672 .
Wladyslawa A Daniel, Maciej Syrek, Anna Haduch & Jacek Wójcikowski. (2009) Pharmacokinetics and metabolism of thioridazine during co‐administration of tricyclic antidepressants. British Journal of Pharmacology 131:2, pages 287-295.
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Juan A. Carrillo, Sara I. Ramos, Angustias G. Herraiz, Adrian Llerena, Jose A. G. Agundez, Roland Berecz, Marisol Duran & Julio Benítez. (1999) Pharmacokinetic Interaction of Fluvoxamine and Thioridazine in Schizophrenic Patients. Journal of Clinical Psychopharmacology 19:6, pages 494-499.
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R. Whelpton. 1997. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists 451 480 .
Ge Lin, Ka-Wing Chu, Lyaquatali A. Damani & Edward M. Hawes. (1996) Identification of lactams as in vitro metabolites of piperidine-type phenothiazine antipsychotic drugs. Journal of Pharmaceutical and Biomedical Analysis 14:6, pages 727-738.
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C.B. Eap, L. Koeb & P. Baumann. (1993) Artifacts in the analysis of thioridazine and other neuroleptics. Journal of Pharmaceutical and Biomedical Analysis 11:6, pages 451-457.
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Shyam K. Singh & Kennedy S. Patrick. (2009) Synthesis of 7‐hydroxythioridazine and 7‐hydroxysulforidazine. Journal of Heterocyclic Chemistry 29:4, pages 995-999.
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G. Lin, K. K. Midha & E. M. Hawes. (2009) Synthesis of the piperidinone metabolites of piperidine type phenothiazine antipsychotic drugs via ruthenium tetroxide oxidation . Journal of Heterocyclic Chemistry 28:2, pages 215-219.
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J.Z. Nowak, S. Arbilla, S.G. Dahl & S.Z. Langer. (1990) Antagonism of presynaptic dopamine receptors by phenothiazine drug metabolites. Life Sciences 46:6, pages 443-451.
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B.S. Chakraborty, K.K. Midha, G. McKay, E.M. Hawes, J.W. Hubbard, E.D. Korchinski, M.G. Choc & W.T. Robinson. (1989) Single Dose Kinetics of Thioridazine and Its Two Psychoactive Metabolites in Healthy Humans: A Dose Proportionality Study. Journal of Pharmaceutical Sciences 78:10, pages 796-801.
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Svein G. Dahl, Elisabeth Kauffmann, Bernard Mompon & Tom Purcell. (1987) Nuclear Magnetic Resonance Analysis of Methotrimeprazine (Levomepromazine) Hydroxylation in Humans. Journal of Pharmaceutical Sciences 76:7, pages 541-544.
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D.A. Ganes & K.K. Midha. (1987) Sensitive and specific high-performance liquid chromatographic assay for the quantification of sulforidazine and two diastereomeric sulforidazine-5-sulfoxide metabolites in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 423, pages 227-237.
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