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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 4
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Research Article

Spectral and inhibitory interactions of methylenedioxyphenyl and related compounds with purified isozymes of cytochrome P-450

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Pages 351-362 | Received 19 Mar 1984, Accepted 09 Oct 1984, Published online: 22 Sep 2008

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Read on this site (6)

Michael Murray. (2016) CYP2J2 – regulation, function and polymorphism. Drug Metabolism Reviews 48:3, pages 351-368.
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Michael Murray. (2012) Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects. Journal of Toxicology and Environmental Health, Part B 15:6, pages 365-395.
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Yasushi Yamazoe, Kazumi Ito & Kouichi Yoshinari. (2011) Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order. Drug Metabolism Reviews 43:4, pages 409-439.
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Marcel Mesnil, Bernard Testa & Peter Jenner. (1988) In vitro Inhibition by Stiripentol of Rat Brain Cytochrome P-450-Mediated Naphthalene Hydroxylation. Xenobiotica 18:9, pages 1097-1106.
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Michael Murray. (2023) Mechanisms and Clinical Significance of Pharmacokinetic Drug Interactions Mediated by FDA and EMA-approved Hepatitis C Direct-Acting Antiviral Agents. Clinical Pharmacokinetics 62:10, pages 1365-1392.
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Stanton Tam, Yassir Al-Zubaidi, Md Khalilur Rahman, Kirsi Bourget, Fanfan Zhou & Michael Murray. (2022) The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells. Pharmacological Reports 74:5, pages 998-1010.
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Pramod C. Nair, Tina B. Gillani, Tristan Rawling & Michael Murray. (2021) Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chemico-Biological Interactions 338, pages 109401.
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Michael Murray, Tina B. Gillani, Tristan Rawling & Pramod C. Nair. (2019) Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib. The AAPS Journal 21:6.
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Sussan Ghassabian, Tina B. Gillani, Tristan Rawling, Severine Crettol, Pramod C. Nair & Michael Murray. (2019) Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4. The AAPS Journal 21:2.
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Yassir Al-Zubaidi, Curtis Pazderka, Nooshin Koolaji, Md Khalilur Rahman, Hassan Choucair, Bala Umashankar, Kirsi Bourget, Yongjuan Chen, Tristan Rawling & Michael Murray. (2019) Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells. European Journal of Pharmaceutical Sciences 129, pages 87-98.
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Michael Murray, Wei V. Zhang & Robert J. Edwards. (2018) Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. Basic & Clinical Pharmacology & Toxicology 122:4, pages 388-395.
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Michael Murray, Tina B. Gillani, Sussan Ghassabian, Robert J. Edwards & Tristan Rawling. (2018) Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver. European Journal of Pharmaceutical Sciences 114, pages 55-63.
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Rui Gu, David E. Hibbs, Jennifer A. Ong, Robert J. Edwards & Michael Murray. (2014) The multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2. Biochemical Pharmacology 88:2, pages 245-252.
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Yanyan Hong, Michael Cho, Yate-Ching Yuan & Shiuan Chen. (2008) Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase. Biochemical Pharmacology 75:5, pages 1161-1169.
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T. Usia, H. Iwata, A. Hiratsuka, T. Watabe, S. Kadota & Y. Tezuka. (2006) CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine 13:1-2, pages 67-73.
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ARTHUR K. CHO, SHIZUO NARIMATSU & YOSHITO KUMAGAI. (1999) Metabolism of drugs of abuse by cytochromes P450. Addiction Biology 4:3, pages 283-301.
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David F.V. Lewis, Costas Ioannides & Dennis V. Parke. (1995) Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501. Toxicology Letters 76:1, pages 39-45.
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Y.-H. Chae, C.B. Marcus, D.K. Ho, J.M. Cassady & W.M. Baird. (1991) Effects of synthetic and naturally occurring flavonoids on benzo[a]pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P-450 inducers. Cancer Letters 60:1, pages 15-24.
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Charles Pidgeon, Joan Stevens, Stephanie Otto, Colin Jefcoate & Craig Marcus. (1991) Immobilized artificial membrane chromatography: Rapid purification of functional membrane proteins. Analytical Biochemistry 194:1, pages 163-173.
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Margaret Lewandowski, Y. C. Chui, Patricia E. Levi & Ernest Hodgson. (2006) Differences in induction of hepatic cytochrome p450 isozymes by mice in eight methylenedioxyphenyl compounds. Journal of Biochemical Toxicology 5:1, pages 47-55.
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Craig B. Marcus, Neil M. Wilson, Ingegerd M. Keith, Colin R. Jefcoate & Curtis J. Omiecinski. (1990) Selective expression of cytochrome P450 isozymes by 4-n-alkyl-methylenedioxybenzenes in rat lung cells. Archives of Biochemistry and Biophysics 277:1, pages 17-25.
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Craig B. Marcus, Neil M. Wilson, Colin R. Jefcoate, Christopher F. Wilkinson & Curtis J. Omiecinski. (1990) Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methylenedioxybenzenes. Archives of Biochemistry and Biophysics 277:1, pages 8-16.
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Marcel Mesnil, Bernard Testa & Peter Jenner. (1988) Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol. Biochemical Pharmacology 37:19, pages 3619-3622.
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David A. Erickson, Mark S. Goodrich & John J. Lech. (1988) The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri). Toxicology and Applied Pharmacology 94:1, pages 1-10.
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Michael Murray. (1987) New heterocyclic modifiers of oxidative drug metabolism—II. Biochemical Pharmacology 36:4, pages 463-468.
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Craig B. Marcus, Michael Murray, Cheng Wang & Christopher F. Wilkinson. (1986) Methylenedioxyphenyl compounds as inducers of cytochrome P-450 and monooxygenase activity in the southern armyworm (Spodoptera eridania) and the rat. Pesticide Biochemistry and Physiology 26:3, pages 310-322.
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Michael Murray, Louise Zaluzny & Geoffrey C. Farrell. (1986) Selective reactivation of steroid hydroxylases following dissociation of the isosafrole metabolite complex with rat hepatic cytochrome P-450. Archives of Biochemistry and Biophysics 251:2, pages 471-478.
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J.F. Brady, E.W. Di Stefano & A.K. Cho. (1986) Spectral and inhibitory interactions of (±)−3, 4-methylenedioxyamphetamine (MDA) and (±)−3, 4-methylenedioxymethampetamine (MDMA) with rat hepatic microsomes. Life Sciences 39:16, pages 1457-1464.
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