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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 8-9
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Original Article

Human hepatocyte cultures: a model of pharmacotoxicological studies

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Pages 635-641 | Published online: 30 Sep 2009

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Read on this site (4)

D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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A. J. M. Woodrooffe, M. K. Bayliss & G. R. Park. (1995) The Effects of Hypoxia on Drug-Metabolizing Enzymes. Drug Metabolism Reviews 27:3, pages 471-495.
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M. Hümpel, D. Sostarek, H. Gieschen & Chr. Labitzky. (1989) Studies on the Biotransformation of Lonazolac, Bromerguride, Lisuride and Terguride in Laboratory Animals and their Hepatocytes. Xenobiotica 19:4, pages 361-377.
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C. Guguen-Guillouzo, P. Gripon, Y. Vandenberghe, F. Lamballe, D. Ratanasavanh & A. Guillouzo. (1988) Hepatotoxicity and molecular aspects of hepatocyte function in primary culture. Xenobiotica 18:6, pages 773-783.
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Articles from other publishers (18)

Tungabidya Maharana, Alekha Kumar Sutar, Anita Routaray, Nibedita Nath & Yuvraj Singh Negi. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 6225 6245 .
Atsushi Matsuzawa, Michiya Matsusaki & Mitsuru Akashi. (2015) Construction of three-dimensional liver tissue models by cell accumulation technique and maintaining their metabolic functions for long-term culture without medium change. Journal of Biomedical Materials Research Part A 103:4, pages 1554-1564.
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T. Kanamori, K. Tsujikawa, Y. Ohmae, Y.T. Iwata, H. Inoue, T. Kishi, T. Nakahama & Y. Inouye. (2005) A study of the metabolism of methamphetamine and 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in isolated rat hepatocytes. Forensic Science International 148:2-3, pages 131-137.
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Martin K. Bayliss & David M. Cross. 2000. The Hepatocyte Review. The Hepatocyte Review 365 389 .
Hui-Ling Chen, Hui-Lin Wu, Chun-Chun Fon, Pei-Jer Chen, Ming-Yang Lai & Ding-Shinn Chen. (1998) Long-term culture of hepatocytes from human adults. Journal of Biomedical Science 5:6, pages 435-440.
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E. Damatte, M. J. Galmier, C. Lartigue-Mattei, J. F. Pognat, N. Busch & J. L. Chabard. (1996) Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity. European Journal of Drug Metabolism and Pharmacokinetics 21:4, pages 315-325.
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Y. Li, G. L. Sattler & H. C. Pitot. (1995) The effect of amino acid composition of serum-free medium on DNA synthesis in primary hepatocyte cultures in the presence of epidermal growth factor. In Vitro Cellular & Developmental Biology - Animal 31:11, pages 867-870.
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M. Hildebrand, M. Hümpel, H. Gieschen & C. Kraus. 1994. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research 1 19 .
Ravi Shrivastava, Gareth John & Roy Massingham. (2006) Calcium antagonists can be classified using in vitro toxicity and potency indices . Journal of Applied Toxicology 12:5, pages 329-332.
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M. Dou, G. de Sousa, B. Lacarelle, M. Placidi, P.Lechene de La Porte, M. Domingo, H. Lafont & R. Rahmani. (1992) Thawed human hepatocytes in primary culture. Cryobiology 29:4, pages 454-469.
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Han Moshage & Sing Hiem Yap. (1992) Primary cultures of human hepatocytes: a unique system for studies in toxicology, virology, parasitology and liver pathophysiology in man. Journal of Hepatology 15:3, pages 404-413.
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L. Qi-Gui, Z. Ming-Da & M. Hümpel. (1991) Investigations on the in vitro metabolism of five synthetic 19-norprogestins using hepatocyte suspensions isolated from five laboratory animal species. European Journal of Drug Metabolism and Pharmacokinetics 16:2, pages 93-102.
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Roger G. Ulrich, Danielle G. Aspar, Clay T. Cramer, Rolf F. Kletzien & Leonard C. Ginsberg. (1990) Isolation and culture of hepatocytes from the cynomolgus monkey (Macaca fascicularis). In Vitro Cellular &Developmental Biology 26:8, pages 815-823.
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K.S. Santone, D.C. Melder & G. Powis. (1989) Studies of chemical toxicity to fresh and cryopreserved rat hepatocytes. Toxicology and Applied Pharmacology 97:2, pages 370-376.
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Charles A. Tyson & Neill H. Stacey. (2016) In Vitro Screens From Cns, Liver and Kidney for Systemic Toxicity. Toxicology and Industrial Health 5:1, pages 107-132.
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Charlene A. McQueen, Barbara M. Way & Gary M. Williams. (1988) Genotoxicity of carcinogens in human hepatocytes: Application in hazard assessment. Toxicology and Applied Pharmacology 96:2, pages 360-366.
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Loranne Agius. (1987) 10 Human liver in vitro techniques for metabolic studies. Baillière's Clinical Endocrinology and Metabolism 1:4, pages 999-1021.
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Marios Marselos, Stephen C. Strom & George Michalopoulos. (1986) Enhancement of aldehyde dehydrogenase activity in human and rat hepatocyte cultures by 3-methylcholanthrene. Cell Biology and Toxicology 2:2, pages 257-269.
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