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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 8-9
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Original Article

A comparison of two cytotoxicity assays for the detection of metabolism-mediated toxicity in vitro: a study with cyclophosphamide

S. A. Horner Department of Human Morphology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
,
J. R. Fry Department of Physiology and Pharmacology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
,
R. H. Clothier Department of Human Morphology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
&
M. Balls Department of Human Morphology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
Pages 681-686 | Published online: 30 Sep 2009

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Jane Ellen Simmons, Ezra Berman, Marcus Jackson & Joellen Lewtas. (1987) In vitro and in vivo toxicity: A comparison of acrylamide, cyclophosphamide, chloroecone, and diethylstilbestrol. Journal of Environmental Science and Health . Part A: Environmental Science and Engineering 22:7, pages 639-664.
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S. A. Horner, J. R. Fry, R. H. Clothier & M. Balls. (1987) The detection of cytotoxicity produced by short-lived reactive intermediates: a study with bromobenzene. Xenobiotica 17:6, pages 777-782.
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Articles from other publishers (16)

Balaji Venkatesagowda. (2019) Enzymatic demethylation of lignin for potential biobased polymer applications. Fungal Biology Reviews 33:3-4, pages 190-224.
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Van T. Ly & Barry Brock. (2011) Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. Chemico-Biological Interactions 193:2, pages 109-118.
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Richard H. Clothier, Karen A. Atkinson, Michael J. Garle, Rachel K. Ward & Angela Willshaw. (2020) The Development and Evaluation of In Vitro Tests by the FRAME Alternatives Laboratory . Alternatives to Laboratory Animals 23:1, pages 75-90.
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Jens-Uwe Voss & Hasso Seibert. (1991) Microcarrier-attached rat hepatocytes as a xenobiotic-metabolizing system in cocultures. Cell Biology and Toxicology 7:4, pages 387-399.
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Toshie Tsuchiya, Heinrich Bürgin, Masahiko Tsuchiya, Paul Winternitz & Andreas Kistler. (1991) Embryolethality of new herbicides is not detected by the micromass teratogen tests. Archives of Toxicology 65:2, pages 145-149.
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David K. Wilcox & Leon H. Bruner. (2020) In Vitro Alternatives for Ocular Safety Testing: An Outline of Assays and Possible Future Developments . Alternatives to Laboratory Animals 18:1_part_1, pages 117-128.
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RJ Riley, P Roberts, MD Coleman, NR Kitteringham & BK Park. (2012) Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.. British Journal of Clinical Pharmacology 30:3, pages 417-426.
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J.R. Fry, M.J. Garle & A.H. Hammond. (1990) Competing pathways in metabolism-mediated cytotoxicity in vitro. Toxicology in Vitro 4:4-5, pages 467-473.
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J.R. Fry, M.J. Garle, A.H. Hammond & A. Hatfield. (1990) Correlation of acute lethal potency with in vitro cytotoxicity. Toxicology in Vitro 4:3, pages 175-178.
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Joerg Lebsanft, James B. McMahon, Gerhard G. Steinmann & Robert H. Shoemaker. (1989) A rapid in vitro method for the evaluation of potential antitumor drugs requiring metabolic activation by hepatic S9 enzymes. Biochemical Pharmacology 38:24, pages 4477-4483.
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. (2012) POSTER COMMUNICATIONS. British Journal of Pharmacology 95:S2.
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Jeffrey R. Fry, Michael J. Garle & Alison H. Hammond. (2020) The Detection of Reactive Metabolites Generated by the Microsomal Mixed Function Oxidase System. Alternatives to Laboratory Animals 16:1, pages 8-13.
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Michael Garle, Alison H. Hammond & Jeffrey R. Fry. (2020) The Cytotoxicity of 27 Chemicals to V79 Chinese Hamster Cells. Alternatives to Laboratory Animals 15:1, pages 30-32.
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H. Babich & E. Borenfreund. (1987) Polycyclic aromatic hydrocarbon in vitro cytotoxicity to bluegill BF-2 cells: Mediation by S-9 microsomal fraction and temperature. Toxicology Letters 36:2, pages 107-116.
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S.A. Horner, F. Zucco, J.R. Fry, R.H. Clothier & M. Balls. (1987) Investigation of the cytotoxicity produced by generation of short-lived reactive metabolites in vitro: A study with paracetamol. Toxicology in Vitro 1:3, pages 133-138.
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Richard Clothier. (2020) Sir. Alternatives to Laboratory Animals 13:2, pages 123-124.
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