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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 8-9
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Original Article

Effects of benorylate and impacina on the metabolism of cultured hepatocytes

J. V. M. Castell Centro de Investigación, Hospital La Fe, Ministerio de Sanidad, Avda. de Campanar 21, 46009, Valencia, Spain
,
A. Montoya Centro de Investigación, Hospital La Fe, Ministerio de Sanidad, Avda. de Campanar 21, 46009, Valencia, Spain
,
A. Larrauri Centro de Investigación, Hospital La Fe, Ministerio de Sanidad, Avda. de Campanar 21, 46009, Valencia, Spain
,
P. LÓPez Centro de Investigación, Hospital La Fe, Ministerio de Sanidad, Avda. de Campanar 21, 46009, Valencia, Spain
&
J. GÓMez-L Centro de Investigación, Hospital La Fe, Ministerio de Sanidad, Avda. de Campanar 21, 46009, Valencia, Spain
Pages 743-749 | Published online: 30 Sep 2009

Citations (19)

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Read on this site (2)

J. V. Castell, A. Larrauri & M. J. GÓmez-LechÓn. (1988) A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica 18:6, pages 737-745.
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M. J. GÓmez-LechÓn, A. Montoya, P. LÓpez, T. Donato, A. Larrauri & J. V. Castell. (1988) The potential use of cultured hepatocytes in predicting the hepatotoxicity of xenobiotics. Xenobiotica 18:6, pages 725-735.
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Articles from other publishers (17)

Roque Bort, M.José Gómez-Lechón, José V Castell & Ramiro Jover. (2004) Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes. Archives of Biochemistry and Biophysics 426:1, pages 63-72.
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Ramiro Jover, Roque Bort, M.José Gómez-Lechón & José V Castell. (1998) Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Letters 431:2, pages 227-230.
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JOSÉ V. CASTELL, MARÍA JOSÉ GÓMEZ-LECHÓN, XAVIER PONSODA & ROQUE BORT. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 375 410 .
ALISON E.M. VICKERS. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 103 127 .
X. Ponsoda, R. Bort, R. Jover, M.J. Gómez-lechón & J.V. Castell. (1995) Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels. Toxicology in Vitro 9:4, pages 439-444.
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Hironori KATOH, Mayumi TSUJI, Masako OKAZAKI & Katsuji OGUCHI. (1993) Coagulative and Fibrinolytic Activities in Primary Cultured Rat Hepatocytes Treated with Carbon Tetrachloride. The Showa University Journal of Medical Sciences 5:1, pages 51-62.
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M.T. Donato, F. Goethals, M.J. Gómez-Lechón, D. Deboyser, I. De Coster, M. Roberfroid & J.V. Castell. (1992) Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicology in Vitro 6:4, pages 295-302.
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Sattar K. Abdul-Hussain & Harihara M. Mehendale. (1991) Studies on the age-dependent effects of galactosamine in primary rat hepatocyte cultures. Toxicology and Applied Pharmacology 107:3, pages 504-513.
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M.T. Donato, M.J. Gómez-Lechón & J.V. Castell. (1991) Rat hepatocytes cultured on a monkey kidney cell line: Expression of biotransformation and hepatic metabolic activities. Toxicology in Vitro 5:5-6, pages 435-438.
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X. Ponsoda, R. Jover, M.J. Gómez-Lechón, R. Fabra, R. Trullenque & J.V. Castell. (1991) The effects of buprenorphine on the metabolism of human hepatocytes. Toxicology in Vitro 5:3, pages 219-224.
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M. José Gómez-Lechón, Pilar López, Teresa Donato, Angel Montoya, Amparo Larrauri, Patricia Giménez, Ramón Trullenque, Ricardo Fabra & José V. Castell. (1990) Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo. In Vitro Cellular & Developmental Biology 26:1, pages 67-74.
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Angel Montoya, Maria J. Gómez-Lechón & Jose V. Castell. (1989) Influence of branched-chain amino acid composition of culture media on the synthesis of plasma proteins by serum-free cultured rat hepatocytes. In Vitro Cellular & Developmental Biology 25:4.
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J. Masanet, M.J. Gómez-Lechón & J.V. Castell. (1988) Hepatic toxicity of paraquat in primary cultures of rat hepatocytes. Toxicology in Vitro 2:4, pages 275-282.
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John Dich, Constance Vind & Niels Grunnet. (1988) Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity. Hepatology 8:1, pages 39-45.
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Angel Montoya & JoséV. Castell. (1987) Long-term storage of peroxidase-labelled immunoglobulins for use in enzyme immunoassay. Journal of Immunological Methods 99:1, pages 13-20.
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J.V. Castell, M.J. Gomez-L, V. Mirabet, M.A. Miranda & I.M. Morera. (1987) Photolytic Degradation of Benorylate: Effects of the Photoproducts on Cultured Hepatocytes. Journal of Pharmaceutical Sciences 76:5, pages 374-378.
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José V. Castell, M. A. José Gómez-Lechón, Miguel A. Miranda & Isabel M. Morera. (1987) Toxic effects of the photoproducts of chlorpromazine on cultured hepatocytes. Hepatology 7:2, pages 349-354.
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