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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 8-9
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Original Article

Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes

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Pages 759-765 | Published online: 30 Sep 2009

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Sherifa A. Hamed. (2016) The effect of epilepsy and antiepileptic drugs on sexual, reproductive and gonadal health of adults with epilepsy. Expert Review of Clinical Pharmacology 9:6, pages 807-819.
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Sherifa A Hamed. (2011) Influences of bone and mineral metabolism in epilepsy. Expert Opinion on Drug Safety 10:2, pages 265-280.
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Thorsten Gerstner, Nellie Bell & Stephan König. (2008) Oral valproic acid for epilepsy - long-term experience in therapy and side effects. Expert Opinion on Pharmacotherapy 9:2, pages 285-292.
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V. Rogiers, Y. Vandenberghe, A. Callaerts, W. Sonck, V. Maes & A. Vercruysse. (1988) The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes. Xenobiotica 18:6, pages 665-673.
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V. Rogiers, G. Paeme, W. Sonck & A. Vercruysse. (1987) Metabolism of procyclidine in isolated rat hepatocytes. Xenobiotica 17:7, pages 849-857.
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V. Rogiers, L. Adriaenssens, Y. Vandenberghe, E. Gepts, A. Callaerts & A. Vercruysse. (1986) Critical evaluation of 7-ethoxycoumarin O-deethylase activity measurement in intact isolated rat hepatocytes. Xenobiotica 16:9, pages 817-826.
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Articles from other publishers (26)

Wei-Jun Wang, Yue-Tao Zhao, Hao-Ran Dai, Yuan-Yuan Zhang, Jie Wang, Hong-Li Guo, Xuan-Sheng Ding & Feng Chen. (2023) Successful LC-MS/MS assay development and validation for determination of valproic acid and its metabolites supporting proactive pharmacovigilance. Journal of Pharmaceutical and Biomedical Analysis 234, pages 115538.
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Sudipa Maity, Ivana Rubić, Josipa Kuleš, Anita Horvatić, Dražen Đuričić, Marko Samardžija, Blanka Beer Ljubić, Romana Turk, Damjan Gračner, Nino Maćešić, Hrvoje Valpotić & Vladimir Mrljak. (2021) Integrated Metabolomics and Proteomics Dynamics of Serum Samples Reveals Dietary Zeolite Clinoptilolite Supplementation Restores Energy Balance in High Yielding Dairy Cows. Metabolites 11:12, pages 842.
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Sabbir Khan, Sandeep Kumar & Gopabandhu Jena. (2016) Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat. Biochimie 125, pages 42-52.
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Sherifa A. Hamed, Ehab M.M. Moussa, Amal M. Tohamy, Khaled O. Mohamed, Mohamad E. Mohamad, Tahra M.K. Sherif & Mostafa M. Abdellah. (2015) Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate. Journal of Clinical Neuroscience 22:3, pages 508-512.
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Sherifa A. Hamed & Mostafa M. Abdella. (2009) The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: Relationship to blood carnitine status. Epilepsy Research 86:1, pages 32-41.
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Salvatore Grosso, Rosa Mostardini, Barbara Piccini & Paolo Balestri. (2009) Body Mass Index and Serum Lipid Changes During Treatment with Valproic Acid in Children with Epilepsy. Annals of Pharmacotherapy 43:1, pages 45-50.
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Cátia C.P. Aires, Graça Soveral, Paula B.M. Luís, Herman J. ten Brink, Isabel Tavares de Almeida, Marinus Duran, Ronald J.A. Wanders & Margarida F.B. Silva. (2008) Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes. FEBS Letters 582:23-24, pages 3359-3366.
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Gook Chan JangEun Young KimYoung Il RhoKyung Rye MoonSang Kee Park. (2007) Valproate-associated weight gain and potential predictors in children with epilepsy. Korean Journal of Pediatrics 50:5, pages 484.
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Stephan A. Koenig, Deike Buesing, Elke Longin, Randi Oehring, Peter Häussermann, Gerhard Kluger, Friedemann Lindmayer, Ralf Hanusch, Ingrid Degen, Hans Kuhn, Kamrun Samii, Albrecht Jungck, Reinhard Brückner, Reinhild Seitz, Wolfgang Boxtermann, Yvonne Weber, Rolf Knapp, Hans Helmut Richard, Birgit Weidner, Johannes-Martin Kasper, Carl-Albrecht Haensch, Sabine Fitzek, Margarete Hartmann, Peter Borusiak, Andrea Müller-Deile, Volker Degenhardt, Georg-Christoph Korenke, Thomas Hoppen, Ulrich Specht & Thorsten Gerstner. (2006) Valproic Acid-induced Hepatopathy: Nine New Fatalities in Germany from 1994 to 2003. Epilepsia 47:12, pages 2027-2031.
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Elaine C Wirrell. (2003) Valproic acid-associated weight gain in older children and teens with epilepsy. Pediatric Neurology 28:2, pages 126-129.
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J. Bauer. 2002. Valproinsäure. Valproinsäure 342 358 .
Şule Seçkin, Canan Başaran-Küçükgergin & Müjdat Uysal. (1999) Effect of Acute and Chronic Administration of Sodium Valproate on Lipid Peroxidation and Antioxidant System in Rat Liver. Pharmacology & Toxicology 85, pages 294-298.
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Gerald P. NovakJoseph Maytal, Anna Alshansky, Lydia Eviatar, Rosemarrie Sy-Kho & Qazi Siddique. (2016) Risk of Excessive Weight Gain in Epileptic Children Treated with Valproate. Journal of Child Neurology 14:8, pages 490-495.
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Matthias Radatz & Heinz Nau. 1999. Valproate. Valproate 91 128 .
Darryl C. De Vivo, Timothy P. Bohan, David L. Coulter, Fritz E. Dreifuss, Robert S. Greenwood, Douglas R. NordliJr.Jr., W. Donald Shields, Carl E. Stafstrom & Ingrid Tein. (2005) l ‐Carnitine Supplementation in Childhood Epilepsy: Current Perspectives . Epilepsia 39:11, pages 1216-1225.
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M. RAZA, A.M. AL-BEKAIRI, A.M. AGEEL & S. QURESHI. (1997) BIOCHEMICAL BASIS OF SODIUM VALPROATE HEPATOTOXICITY AND RENAL TUBULAR DISORDER: TIME DEPENDENCE OF PEROXIDATIVE INJURY. Pharmacological Research 35:2, pages 153-157.
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F. Gofflot, B. Nihoul, G. Van Maele-Fabry, F. Goethals & J.J. Picard. (1994) Developmental toxicity of valproic acid assessed in a sequential culture of hepatocytes and embryos. Toxicology in Vitro 8:2, pages 181-189.
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V. Rogiers & A. Vercruysse. (1993) Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology 82:1-3, pages 193-208.
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Henrik Vorum, Lennart Gram & Bent Honoré. (1993) Valproate and palmitate binding to serum albumin in valproate-treated patients. relation to obesity. Epilepsy Research 16:1, pages 55-64.
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Sylvie Ponchaut & Keith Veitch. (1993) Valproate and mitochondria. Biochemical Pharmacology 46:2, pages 199-204.
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Roberto Riva, Fiorenzo Albani, Giuseppe Gobbi, Margherita Santucci & Agostino Baruzzi. (2005) Carnitine Disposition Before and During Valproate Therapy in Patients with Epilepsy. Epilepsia 34:1, pages 184-187.
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Sylvie Ponchaut, Francois Van Hoof & Keith Veitch. (1992) In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Biochemical Pharmacology 43:11, pages 2435-2442.
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Sylvie Ponchaut, Jean Pierre Draye, Keith Veitch & Francois Van Hoof. (1991) Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Biochemical Pharmacology 41:10, pages 1419-1428.
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Keith Veitch & François Van Hoof. (1990) In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. Biochemical Pharmacology 40:9, pages 2153-2159.
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John Osterloh, William Cunningham, Alison Dixon & David Combest. (2012) Biochemical Relationships Between Reye’s and Reye’s-Like Metabolic and Toxicological Syndromes. Medical Toxicology and Adverse Drug Experience 4:4, pages 272-294.
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M. J. Eadie, W. D. Hooper & R. G. Dickinson. (2012) Valproate-Associated Hepatotoxicity and its Biochemical Mechanisms. Medical Toxicology 3:2, pages 85-106.
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