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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 10-11
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Original Article

Pathways involved in the metabolism and activation of polycyclic hydrocarbons

Pages 915-931 | Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Laura Campo, Petra Bechtold, Lucia Borsari & Silvia Fustinoni. (2019) A systematic review on biomonitoring of individuals living near or working at solid waste incinerator plants. Critical Reviews in Toxicology 49:6, pages 479-519.
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StevenR. Myers. (2007) BIOALKYLATION OF BENZ(A)ANTHRACENE: IMPLICATIONS FOR CARCINOGENESIS. Polycyclic Aromatic Compounds 27:4, pages 311-337.
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LyndaL. Song, StevenR. Myers, Dan Lantvit, RonaldA. Lubet, VernonE. Steele, GaryJ. Kelloff, RichardC. Moon & JohnM. Pezzuto. (2000) Chemoprevention of DMBA-induced Mammary Carcinogenesis: Relationship Between Induction of Phase II Enzymes, Effects on DMBA-induced Hemoglobin Adducts and Decreases in Mammary Tumor Multiplicity. Polycyclic Aromatic Compounds 18:2, pages 193-210.
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Dennis V. Parke. (1997) A History of Drug Metabolism in the United Kingdom. Drug Metabolism Reviews 29:3, pages 801-851.
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Zheng Ouyang, Arthur Greenberg, GloriaY. Kwei, FrederickC. Kauffman & Ellen Faria. (1995) A Rapid Assay for Urinary Metabolites of Benzo[a]pyrene (B[a]P). Polycyclic Aromatic Compounds 5:1-4, pages 259-268.
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Ed Nelson. (1992) Determination of Mercapturic Acid Excretions in Exposure Control to Toxicants. Critical Reviews in Toxicology 22:5-6, pages 371-389.
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C. O. Kumi, R. A. Nicholson & F. C. P. Law. (1991) Absorption, degradation and excretion of benzo(a)pyrene in the cricket (Acheta domesticus). Xenobiotica 21:10, pages 1357-1362.
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Articles from other publishers (47)

Fahimeh Salami, Yaghoub Hajizadeh, Ghasem Yadegarfar, Karim Ebrahimpour, Hamidreza Pourzamani & Parinaz Poursafa. (2021) Urinary levels of PAH metabolites in pregnant women and their correlation with sociodemographic factors and PM2.5 exposure in an urban and a suburban area. Air Quality, Atmosphere & Health 14:5, pages 653-665.
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A. N. Alekseenko, O. M. Zhurba, A. V. Merinov & S. F. Shayakhmetov. (2020) Optimization of conditions for the sample preparation using mathematical planning for determination of 1-hydroxypyrene in urine using method of gas chromatography-mass spectrometry. Hygiene and sanitation 99:10, pages 1153-1158.
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Meiqing Lin, Jian Tang, Shengtao Ma, Yingxin Yu, Guiying Li, Ruifang Fan, Bixian Mai & Taicheng An. (2020) Insights into biomonitoring of human exposure to polycyclic aromatic hydrocarbons with hair analysis: A case study in e-waste recycling area. Environment International 136, pages 105432.
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Kai Luo, Qun Gao & Jianying Hu. (2019) Determination of 3-Hydroxybenzo[a]pyrene Glucuronide/Sulfate Conjugates in Human Urine and Their Association with 8-Hydroxydeoxyguanosine. Chemical Research in Toxicology 32:7, pages 1367-1373.
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Laura Campo, Elisa Polledri, Petra Bechtold, Giulia Gatti, Giulia Quattrini, Luca Olgiati, Michael Romolo, Andrea Ranzi, Paolo Lauriola, Giuliano Carrozzi & Silvia Fustinoni. (2018) ETS Exposure and PAH Body Burden in Nonsmoking Italian Adults. International Journal of Environmental Research and Public Health 15:6, pages 1156.
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Laura Campo, Mariem Hanchi, Luca Olgiati, Elisa Polledri, Dario Consonni, Ines Zrafi, Dalila Saidane-Mosbahi & Silvia Fustinoni. (2016) Biological Monitoring of Occupational Exposure to Polycyclic Aromatic Hydrocarbons at an Electric Steel Foundry in Tunisia. Annals of Occupational Hygiene 60:6, pages 700-716.
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Bibi Yasin, Hassan El-Fawal & Shaker Mousa. (2015) Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. International Journal of Molecular Sciences 16:12, pages 30075-30090.
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Abhishek Chauhan, Tejasvi Bhatia, Amarnath Singh, Prem Narain Saxena, C. Kesavchandran & Mohana Krishna Reddy Mudiam. (2015) Application of nano-sized multi-template imprinted polymer for simultaneous extraction of polycyclic aromatic hydrocarbon metabolites in urine samples followed by ultra-high performance liquid chromatographic analysis. Journal of Chromatography B 985, pages 110-118.
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Kai Luo, Qun Gao & Jianying Hu. (2015) Derivatization method for sensitive determination of 3-hydroxybenzo[a]pyrene in human urine by liquid chromatography–electrospray tandem mass spectrometry. Journal of Chromatography A 1379, pages 51-55.
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Marc R. Elie, Christian A. Clausen & Cherie L. Geiger. (2012) Reduction of benzo[a]pyrene with acid-activated magnesium metal in ethanol: A possible application for environmental remediation. Journal of Hazardous Materials 203-204, pages 77-85.
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Kristian Dreij, Qasim Ali Chaudhry, Bengt Jernström, Ralf Morgenstern & Michael Hanke. (2011) A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry. PLoS ONE 6:8, pages e23128.
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Chiara Scanarotti, Anna Maria Bassi, Mariafrancesca Catalano, Chiara Guida, Rosella Coradeghini, Carla Falugi, Mariagrazia Aluigi, Pierluigi Santi & Edoardo Raposio. (2010) Neurogenic-committed human pre-adipocytes express CYP1A isoforms. Chemico-Biological Interactions 184:3, pages 474-483.
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Carine Jacques, Emilien L. Jamin, Elisabeth Perdu, Hélène Duplan, Alain Mavon, Daniel Zalko & Laurent Debrauwer. (2010) Characterisation of B(a)P metabolites formed in an ex vivo pig skin model using three complementary analytical methods. Analytical and Bioanalytical Chemistry 396:5, pages 1691-1701.
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Sandra L. Kabler, Albrecht Seidel, Juergen Jacob, Johannes Doehmer, Charles S. Morrow & Alan J. Townsend. (2009) Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1. Chemico-Biological Interactions 179:2-3, pages 240-246.
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Zheng Li, Courtney D. Sandau, Lovisa C. Romanoff, Samuel P. Caudill, Andreas Sjodin, Larry L. Needham & Donald G. PattersonJr.Jr.. (2008) Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population. Environmental Research 107:3, pages 320-331.
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Bo Chen, Yunping Hu, Taiyi Jin, Daru Lu, Minhua Shao, Lixing Zheng, Qiangyi Wang, Yue Shen, Hongliang Liu, Yanhong Liu & Yuanfen Zhou. (2007) The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Science of The Total Environment 381:1-3, pages 38-46.
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Zheng Li, Lovisa C. Romanoff, Debra A. Trinidad, Nasira Hussain, Richard S. Jones, Erin N. Porter, Donald G. Patterson & Andreas Sjödin. (2006) Measurement of Urinary Monohydroxy Polycyclic Aromatic Hydrocarbons Using Automated Liquid−Liquid Extraction and Gas Chromatography/Isotope Dilution High-Resolution Mass Spectrometry. Analytical Chemistry 78:16, pages 5744-5751.
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Lovisa C. Romanoff, Zheng Li, Kisha J. Young, Nelson C. BlakelyIIIIII, Donald G. PattersonJr.Jr. & Courtney D. Sandau. (2006) Automated solid-phase extraction method for measuring urinary polycyclic aromatic hydrocarbon metabolites in human biomonitoring using isotope-dilution gas chromatography high-resolution mass spectrometry. Journal of Chromatography B 835:1-2, pages 47-54.
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Christopher A. Evans, Harvey E. Fries & Keith W. Ward. (2005) In vitro metabolic fate of a novel structural class: Evidence for the formation of a reactive intermediate on a benzothiophene moiety. Chemico-Biological Interactions 152:1, pages 25-36.
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Joseph M Gozgit, Kathleen M Nestor, Michael J Fasco, Brian T Pentecost & Kathleen F Arcaro. (2004) Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells. Toxicology and Applied Pharmacology 196:1, pages 58-67.
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Andrew Maier, Brenda L. Schumann, Xiaoqing Chang, Glenn Talaska & Alvaro Puga. (2002) Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 517:1-2, pages 101-111.
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Praveen K. Vayalil. (2002) Antioxidant and Antimutagenic Properties of Aqueous Extract of Date Fruit ( Phoenix dactylifera L. Arecaceae) . Journal of Agricultural and Food Chemistry 50:3, pages 610-617.
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John A. Craft, Fiona E. Robertson, Mary E. McPhail, Elaine Brown & Ronald M. Stagg. (2001) Measurement of cytochrome P4501A induction in dab (Limanda limanda) and other teleosts with species-specific cDNA probes: isolation and characterisation of dab cDNA and its use in expression studies with β-naphthoflavone-treated fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 129:2, pages 115-127.
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Chris S. Hofelt, Michael Honeycutt, J.Torin McCoy & Laurie C. Haws. (2001) Development of a Metabolism Factor for Polycyclic Aromatic Hydrocarbons for Use in Multipathway Risk Assessments of Hazardous Waste Combustion Facilities. Regulatory Toxicology and Pharmacology 33:1, pages 60-65.
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