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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 1
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Original Article

Metabolism of 14C-estazolam in dogs and humans

J. M. Machinist Department of Drug Metabolism, Abbott Laboratories, North Chicago, IL, 60064, USA
,
B. A. Bopp Department of Drug Metabolism, Abbott Laboratories, North Chicago, IL, 60064, USA
,
D. J. Anderson Department of Drug Metabolism, Abbott Laboratories, North Chicago, IL, 60064, USA
,
G. R. Granneman Department of Drug Metabolism, Abbott Laboratories, North Chicago, IL, 60064, USA
,
R. C. Sonders Department of Drug Metabolism, Abbott Laboratories, North Chicago, IL, 60064, USA
,
K. Tolman Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, 84132, USA
,
K. Buchi Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, 84132, USA
&
D. Rollins Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, 84132, USA
 show all
Pages 11-20 | Received 06 Jan 1984, Published online: 30 Sep 2009

Citations (12)

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Read on this site (1)

M. Miura, K. Otani & T. Ohkubo. (2005) Identification of human cytochrome P450 enzymes involved in the formation of 4-hydroxyestazolam from estazolam. Xenobiotica 35:5, pages 455-465.
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Articles from other publishers (11)

Xin Zhang, Jiachen Shi, Xiaoyong Huang & Bing Shao. (2022) Formation and occurrence of disinfection byproducts of benzodiazepine drug estazolam in drinking water of Beijing. Science of The Total Environment 804, pages 150028.
Crossref
R. Scott Obach. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 41 .
Xingxing Diao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Xingxing Diao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Toshiaki Aoshima, Takashi Fukasawa, Yohei Otsuji, Naoyuki Okuyama, Gisa Gerstenberg, Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara & Koichi Otani. (2003) Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam. Progress in Neuro-Psychopharmacology and Biological Psychiatry 27:3, pages 535-538.
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Yohei Otsuji, Naoyuki Okuyama, Toshiaki Aoshima, Takashi Fukasawa, Kimiyasu Kato, Gisa Gerstenberg, Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara & Koichi Otani. (2002) No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam. Therapeutic Drug Monitoring 24:3, pages 375-378.
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Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara, Naoyuki Okuyama & Koichi Otani. (2002) Determination of Estazolam in Plasma by High-Performance Liquid Chromatography with Solid-Phase Extraction. Analytical Sciences 18:5, pages 525-528.
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Deepak K. Dalvie, Amit S. Kalgutkar, S. Cyrus Khojasteh-Bakht, R. Scott Obach & John P. O'Donnell. (2002) Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings. Chemical Research in Toxicology 15:3, pages 269-299.
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Martin B. Scharf, Paul B. Roth, Roberto A. Dominguez & J. Catesby Ware. (2013) Estazolam and Flurazepam: A Multicenter, Placebo‐Controlled Comparative Study in Outpatients with Insomnia. The Journal of Clinical Pharmacology 30:5, pages 461-467.
Crossref
David J. Greenblatt, Lawrence G. Miller & Richard I. Shader. (1990) Neurochemical and pharmacokinetic correlates of the clinical action of benzodiazepine hypnotic drugs. The American Journal of Medicine 88:3, pages S18-S24.
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Linda E. Gustavson & Philip J. Carrigan. (1990) The clinical pharmacokinetics of single doses of estazolam. The American Journal of Medicine 88:3, pages S2-S5.
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