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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 1
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Original Article

Identification and quantitative determination of four different mercapturic acids formed from 1,3-dibromopropane and its 1,1,3,3-tetradeutero analogue by the rat

W. Onkenhout Department of Pharmaceutical Analysis, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands
,
E. J. C. Van Bergen Department of Pharmaceutical Analysis, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands
,
J. H. F. Van Der Wart Department of Pharmaceutical Analysis, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands
,
G. P. Vos Department of Pharmacology, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands
,
W. Buijs Department of Organic Chemistry, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands
&
N. P. E. Vermeulen Department of Pharmaceutical Analysis, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands; Department of Pharmacology, State University Leiden, Gorlaeus Laboratories, PO Box 9502, 2300, RA, Leiden, The Netherlands; Department of Medicinal Chemistry, Molecular Toxicology, Free University, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
Pages 21-33 | Received 14 Dec 1984, Published online: 30 Sep 2009

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Sang Kyu Lee, Dong Ju Lee, Hemin Jeong, SudeepR. Bista, Mi Jeong Kang, Eung Seok Lee, Jong Keun Son, Doo Hyun Nam, Hyeun Wook Chang, Seung Ho Lee, Yurngdong Jahng & Tae Cheon Jeong. (2007) Hepatotoxic and Immunotoxic Effects produced by 1,3‐Dibromopropane and Its Conjugation with Glutathione in Female BALB/c Mice. Journal of Toxicology and Environmental Health, Part A 70:15-16, pages 1381-1390.
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J. P. G. Brakenhoff, J. N. M. Commandeur, M. H. LamorÉE, A. C. Dubelaar, B.L.M. Van Baar, C. Lucas & N. P. E. Vermeulen. (1993) Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent. Xenobiotica 23:8, pages 935-947.
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Ronald T. H. van Welie, Rob G. J. M. van Dijck, Nico P. E. Vermeulen & Nico J. van Sittert. (1992) Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals. Critical Reviews in Toxicology 22:5-6, pages 271-306.
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M. J. Bartels & C. Timchalk. (1990) 1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat. Xenobiotica 20:10, pages 1035-1042.
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Articles from other publishers (13)

K. Udeni Alwis, Benjamin C. Blount, April S. Britt, Dhrusti Patel & David L. Ashley. (2012) Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS). Analytica Chimica Acta 750, pages 152-160.
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Mutsuko Hirata‐Koizumi, Ryuichi Hasegawa, Akihiko Hirose & Makoto Ema. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Yan S. Ding, Benjamin C. Blount, Liza Valentin-Blasini, Heather S. Applewhite, Yang Xia, Clifford H. Watson & David L. Ashley. (2009) Simultaneous Determination of Six Mercapturic Acid Metabolites of Volatile Organic Compounds in Human Urine. Chemical Research in Toxicology 22:6, pages 1018-1025.
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Ryuichi Hasegawa, Mutsuko Hirata-Koizumi, Mika Takahashi, Eiichi Kamata & Makoto Ema. (2005) Comparative susceptibility of newborn and young rats to six industrial chemicals. Congenital Anomalies 45:4, pages 137-145.
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Mutsuko HIRATA-KOIZUMI, Osamu KUSUOKANobuo NISHIMURAHajime WADAHidehiro OGATANaemi FUKUDA, Yoshihiko ITO, Eiichi KAMATA, Makoto EMA & Ryuichi HASEGAWA. (2005) SUSCEPTIBILITY OF NEWBORN RATS TO HEPATOTOXICITY OF 1,3-DIBROMOPROPANE AND 1,1,2,2-TETRABROMOETHANE, COMPARED WITH YOUNG RATS. The Journal of Toxicological Sciences 30:1, pages 29-42.
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M Hassan. (1999) The role of busulfan in bone marrow transplantation. Medical Oncology 16:3, pages 166-176.
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C.S. Perry, X. Liu, L.G. Lund, C.P. Whitman & J.P. Kehrer. (1995) Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells. Toxicology in Vitro 9:1, pages 21-26.
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Michael J. Bartels. (1994) Quantitation of the tetrachloroethylene metaboliteN-acetyl-S-(trichlorovinyl)cysteine in rat urinevia negative ion chemical ionization gas chromatography/tandem mass spectrometry. Biological Mass Spectrometry 23:11, pages 689-694.
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C J HogueM A Brewster. (1991) The potential of exposure biomarkers in epidemiologic studies of reproductive health.. Environmental Health Perspectives 90, pages 261-269.
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B. Sinu?s, M. Izquierdo & J. Perez Viguera. (1990) Chromosome aberrations and urinary thioethers in smokers. Mutation Research/Genetic Toxicology 240:4, pages 289-293.
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A. L. Burlingame, D. Maltby, D. H. Russell & P. T. Holland. (2002) Mass spectrometry. Analytical Chemistry 60:12, pages 294-342.
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Joachim Jandke & Gerhard Spiteller. (1987) Unusual conjugates in biological profiles originating from consumption of onions and garlic. Journal of Chromatography B: Biomedical Sciences and Applications 421, pages 1-8.
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W. Onkenhout, P. P. J. Mulder, P. J. Boogaard, W. Buijs & N. P. E. Vermeulen. (1986) Identification and quantitative determination of mercapturic acids formed from Z- and E-1,3-dichloropropene by the rat, using gas chromatography with three different detection techniques. Archives of Toxicology 59:4, pages 235-241.
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