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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 1
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Original Article

Further studies on the pharmacokinetics of perhexiline maleate in humans

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Pages 63-68 | Received 02 Mar 1984, Accepted 12 Aug 1985, Published online: 30 Sep 2009

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Christopher H. George, Alice N. Mitchell, Ryan Preece, Mark L. Bannister & Zaheer Yousef. (2016) Pleiotropic mechanisms of action of perhexiline in heart failure. Expert Opinion on Therapeutic Patents 26:9, pages 1049-1059.
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Giovanni Licari, Andrew A. Somogyi, Robert W. Milne & Benedetta C. Sallustio. (2015) Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague–Dawley and Dark Agouti rats. Xenobiotica 45:1, pages 3-9.
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R.G. Morris, B.C. Sallustio, N.C. Saccoia, S. Mangas, L.K. Fergusson & C. Kassapidis. (1992) Application of an Improved HPLC Perhexiline Assay to Human Plasma Specimens. Journal of Liquid Chromatography 15:18, pages 3219-3232.
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R. G. Cooper, S. A. Jenkins, D. A. Price Evans & A. H. Price. (1988) The enterohepatic circulation of perhexiline metabolites in the male Wistar rat. Xenobiotica 18:4, pages 389-396.
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B. J. Gould, A. G. B. Amoah & D. V. Parke. (1986) Stereoselective pharmacokinetics of perhexiline. Xenobiotica 16:5, pages 491-502.
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Articles from other publishers (15)

Zhen Ren, Si Chen, Xuan Qin, Feng Li & Lei Guo. (2022) Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline. Archives of Toxicology 96:12, pages 3219-3231.
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Rowena L. Sison-Young, Volker M. Lauschke, Esther Johann, Eliane Alexandre, Sébastien Antherieu, Hélène Aerts, Helga H. J. Gerets, Gilles Labbe, Delphine Hoët, Martina Dorau, Christopher A. Schofield, Cerys A. Lovatt, Julie C. Holder, Simone H. Stahl, Lysiane Richert, Neil R. Kitteringham, Robert P. Jones, Mohamed Elmasry, Richard J. Weaver, Philip G. Hewitt, Magnus Ingelman-Sundberg, Chris E. Goldring & B. Kevin Park. (2016) A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Archives of Toxicology 91:3, pages 1385-1400.
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Simone Esposito, Elena Bracacel, Martina Nibbio, Roberto Speziale, Laura Orsatti, Maria Veneziano, Edith Monteagudo & Fabio Bonelli. (2016) Use of ‘dilute-and-shoot’ liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma. Journal of Pharmaceutical and Biomedical Analysis 118, pages 70-80.
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Liang-han Ling, William Chik, Paula Averbuj, Purendra K Pati, Aaron L Sverdlov, Doan T M Ngo, Raymond G Morris, Benedetta C Sallustio & John D Horowitz. (2011) Effects of Aging, Renal Dysfunction, Left Ventricular Systolic Impairment, and Weight on Steady State Pharmacokinetics of Perhexiline. Therapeutic Drug Monitoring 33:2, pages 251-256.
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Benjamin J. Davies, Megan K. Herbert, Janet K. Coller, Andrew A. Somogyi, Robert W. Milne & Benedetta C. Sallustio. (2008) Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline. British Journal of Clinical Pharmacology 65:3, pages 347-354.
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Sally C. Inglis, Megan K. Herbert, Benjamin J.L. Davies, Janet K. Coller, Heather M. James, John D. Horowitz, Raymond G. Morris, Robert W. Milne, Andrew A. Somogyi & Benedetta C. Sallustio. (2007) Effect of CYP2D6 metabolizer status on the disposition of the (+) and (−) enantiomers of perhexiline in patients with myocardial ischaemia. Pharmacogenetics and Genomics 17:5, pages 305-312.
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Terry E. Jones, Raymond G. Morris & John D. Horowitz. (2003) Concentration-time profile for perhexiline and hydroxyperhexiline in patients at steady state. British Journal of Clinical Pharmacology 57:3, pages 263-269.
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Benedetta C. Sallustio, Ian S. Westley & Raymond G. Morris. (2002) Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady‐state dose. British Journal of Clinical Pharmacology 54:2, pages 107-114.
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Riffatt Hussein, Bruce G. Charles, Raymond G. Morris & Rohan L. Rasiah. (2001) Population Pharmacokinetics of Perhexiline From Very Sparse, Routine Monitoring Data. Therapeutic Drug Monitoring 23:6, pages 636-643.
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Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef & A. Ziegler. 1994. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1 467 .
David F.V. Lewis, C. Ioannides & D.V. Parke. (1993) Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTP. Mutation Research/Environmental Mutagenesis and Related Subjects 291:1, pages 61-77.
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Mont R. Juchau, Robert J. Walker, J. Paul Fawcett, R. Sutherland, Noel W. Preston, Sanjay Batra, Manju Seth, A. P. Bhaduri, Wilhelm Schoner, James W. Fisher, Hiroshi Ohtaka & Toshio FujitaSanjay Batra, Manju Seth & A. P. Bhaduri. 1993. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 191 248 .
Charles T. Eason, Frank W. Bonner & Dennis V. Parke. (1990) The importance of pharmacokinetic and receptor studies in drug safety evaluation. Regulatory Toxicology and Pharmacology 11:3, pages 288-307.
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F. Jamali, R. Mehvar & F.M. Pasutto. (1989) Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls. Journal of Pharmaceutical Sciences 78:9, pages 695-715.
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R. G. Cooper, D. A. P. Evans & A. H. Price. (1987) Studies on the metabolism of perhexiline in man. European Journal of Clinical Pharmacology 32:6, pages 569-576.
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