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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 1
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Original Article

Observation of drug metabolites and endogenous compounds in human urine by 1H nuclear magnetic resonance spectroscopy

M. D. Coleman School of Biochemistry, University of New South Wales, P.O. Box 1, Kensington, 2033, Australia
&
R. S. Norton School of Biochemistry, University of New South Wales, P.O. Box 1, Kensington, 2033, Australia
Pages 69-77 | Received 05 Feb 1985, Published online: 30 Sep 2009

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Michael S. Monaghan, Keith M. Olsen, Bruce H. Ackerman, Gary L. Fuller, William H. Porter & Alex A. Pappas. (1995) Measurement of Serum Isopropanol and the Acetone Metabolite by Proton Nuclear Magnetic Resonance: Application to Pharmacokinetic Evaluation in a Simulated Overdose Model. Journal of Toxicology: Clinical Toxicology 33:2, pages 141-149.
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M. C. Malet-Martino & R. Martino. (1989) The Application of Nuclear Magnetic Resonance Spectroscopy to Drug Metabolism Studies. Xenobiotica 19:6, pages 583-607.
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Articles from other publishers (19)

Alma Villaseñor, James M. Kinross, Jia V. Li, Nicholas Penney, Richard H. Barton, Jeremy K. Nicholson, Ara Darzi, Coral Barbas & Elaine Holmes. (2014) 1 H NMR Global Metabolic Phenotyping of Acute Pancreatitis in the Emergency Unit . Journal of Proteome Research 13:12, pages 5362-5375.
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Eun Mi Park, Eunil Lee, Hyun Jin Joo, Eunha Oh, Joohyun Lee & Ji-Sung Lee. (2009) Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using 1H NMR spectroscopy. Clinical Chemistry and Laboratory Medicine 47:2.
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K.L Behar. 1997. Stable Isotopes in Pharmaceutical Research. Stable Isotopes in Pharmaceutical Research 141 168 .
Alex A. Pappas, Richard A. Komoroski, Jennifer R. Thompson & Aubrey J. HoughJrJr. (1992) Nuclear magnetic resonance spectroscopy in pathology: II. Current and future clinical applications. Human Pathology 23:1, pages 4-12.
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Nihal S. Agar, Caroline D. Rae, Bogdan E. Chapman & Philip W. Kuchel. (1991) 1H NMR spectroscopic survey of plasma and erythrocytes from selected marsupials and domestic animals of Australia. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 99:3, pages 575-597.
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J. D. Bell, D. G. Gadian & N. E. Preece. (1990) NMR studies of drug metabolism and disposition. European Journal of Drug Metabolism and Pharmacokinetics 15:2, pages 127-133.
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K.E. Wade, I.D. Wilson, J.A. Troke & J.K. Nicholson. (1990) 19F and 1H magnetic resonance strategies for metabolic studies on fluorinated xenobiotics: Application to flurbiprofen [2-(2-fluoro-4-biphenylyl)propionic acid]. Journal of Pharmaceutical and Biomedical Analysis 8:5, pages 401-410.
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Judith C. C. Brown, Graham A. Mills, Peter J. Sadler & Valerie Walker. (2005) 1 H NMR studies of urine from premature and sick babies . Magnetic Resonance in Medicine 11:2, pages 193-201.
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Sarah K. Branch & Alan F. Casy. 1989. 355 436 .
Jeremy K. Nicholson & Ian D. Wilson. (1989) High resolution proton magnetic resonance spectroscopy of biological fluids. Progress in Nuclear Magnetic Resonance Spectroscopy 21:4-5, pages 449-501.
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J. K. Nicholson. 1989. Clinical Chemistry. Clinical Chemistry 9 26 .
I. M. Brereton, J. Field, L. N. Moxon, M. G. Irving & D. M. Doddrell. (2005) Water suppression with B 0 field gradient homospoil pulses in high‐resolution NMR spectroscopy . Magnetic Resonance in Medicine 9:1, pages 118-125.
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K. E. Wade, J. Troke, C. M. Macdonald, I. D. Wilson & J. K. Nicholson. 1988. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular 383 388 .
S. M. Sanins, J. A. Timbrell, C. Elcombe & J. K. Nicholson. 1988. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular 375 381 .
S. Connor, J. Everett & J. K. Nicholson. (2005) Spin‐echo proton NMR spectroscopy of urine samples. Water suppression via a urea‐Dependent T 2 relaxation process . Magnetic Resonance in Medicine 4:5, pages 461-470.
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Ian D. Wilson, John Fromson, Ismail M. Ismail & Jeremy K. Nicholson. (1987) Proton magnetic resonance spectroscopy of human urine: Excretion of 1-(3?-carboxypropyl)-3,7-dimethylxanthine by man after dosing with oxpentifylline. Journal of Pharmaceutical and Biomedical Analysis 5:2, pages 157-163.
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J. K. Nicholson & Ian D. Wilson. 1987. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques 427 479 .
J. K. Nicholson, P. J. Sadler, K. Tulip & J. A. Timbrell. 1986. BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers. BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers 321 335 .
Helen Allars, Malcolm D. Coleman & Raymond S. Norton. (2010) 1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver. European Journal of Drug Metabolism and Pharmacokinetics 10:3, pages 253-260.
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