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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 3
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Research Article

The chromatographic analysis of enantiomers in drug metabolism studies

Bernard Testa School of Pharmacy, University of Lausanne, CH-1005, Lausanne, Switzerland
Pages 265-279 | Received 30 Jun 1985, Published online: 22 Sep 2008

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MohamedM. Hefnawy & JamesT. Stewart. (1998) Resolution of Enantiomers of Tropicamide by Reversed-Phase High Performance Liquid Chromatography Using Hydroxypropyl-β-cyclodextrin as Chiral Mobile Phase Additive. Analytical Letters 31:4, pages 659-667.
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Articles from other publishers (41)

Klaus Möller & Kurt Günther. 2003. Handbook of Thin-Layer Chromatography. Handbook of Thin-Layer Chromatography.
B. Testa & J. M. Mayer. 2003. Stereochemical Aspects of Drug Action and Disposition. Stereochemical Aspects of Drug Action and Disposition 143 159 .
S. C. Tan, S. H. D. Jackson, C. G. Swift & A. J. Hutt. (1997) Enantiospecific analysis of ibuprofen by high performance liquid chromatography: Determination of free and total drug enantiomer concentrations in serum and urine. Chromatographia 46:1-2, pages 23-32.
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Yukiko Makino, Shigeru Ohta & Masaaki Hirobe. (1996) Enantiomeric separation of amphetamine by high-performance liquid chromatography using chiral crown ether-coated reversed-phase packing: application to forensic analysis. Forensic Science International 78:1, pages 65-70.
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M. F. LANDONI & P. LEES. (2008) Chirality: a major issue in veterinary pharmacology. Journal of Veterinary Pharmacology and Therapeutics 19:1, pages 82-84.
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Yoji Tokuma & Hideyo Noguchi. (1995) Stereoselective pharmacokinetics of dihydropyridine calcium antagonists. Journal of Chromatography A 694:1, pages 181-193.
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Maria Fabiana Landoni & Peter Lees. (2004) Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers in calves. Chirality 7:8, pages 586-597.
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Pierre Leroy, Luc Bellucci & Alain Nicolas. (2004) Chiral derivatization for separation of racemic amino and thiol drugs by liquid chromatography and capillary electrophoresis. Chirality 7:4, pages 235-242.
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E. Frigerio, E. Pianezzola & M.Strolin Benedetti. (1994) Sensitive procedure for the determination of reboxetine enantiomers in human plasma by reversed-phase high-performance liquid chromatography with fluorimetric detection after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate. Journal of Chromatography A 660:1-2, pages 351-358.
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Gaétan Caron, George W.-M. Tseng & Romas J. Kazlauskas. (1994) Kinetic resolutions concentrate the minor enantiomer and aid measurement of high enantiomeric purity.. Tetrahedron: Asymmetry 5:1, pages 83-92.
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Damon S. Jack, Roger H. Rumble, Noel W. Davies & Hilton W. Francis. (1992) Enantiospecific gas chromatographic—mass spectrometric procedure for the determination of ketoprofen and ibuprofen in synovial fluid and plasma: application to protein binding studies. Journal of Chromatography B: Biomedical Sciences and Applications 584:2, pages 189-197.
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John Caldwell PhD. (2013) The Importance of Stereochemistry in Drug Action and Disposition. The Journal of Clinical Pharmacology 32:10, pages 925-929.
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Nuggehally R. Srinivas & Linus N. Igwemezie. (2005) Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection. Biomedical Chromatography 6:4, pages 163-167.
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A.M. Dyas. (1992) The chiral chromatographic separation of β-adrenoceptor blocking drugs. Journal of Pharmaceutical and Biomedical Analysis 10:6, pages 383-404.
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Yoshihiko Shinohara, Hiroshi Magara & Swgeo Baba. (1991) Stereoselective Pharmacokinetics and Inversion of Suprofen Enantiomers in Humans. Journal of Pharmaceutical Sciences 80:11, pages 1075-1078.
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Masayuki Nakano & Seiichi Kawahara. (1991) High-performance liquid chromatographic method for simultaneous determination of enantiomers of 5-dimethylsulphamoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid and its N-monodemethyl metabolite in monkey plasma and urine after chiral derivatization. Journal of Chromatography B: Biomedical Sciences and Applications 564:1, pages 235-241.
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Colin F. Poole & Salwa K. Poole. 1991. Chromatography Today. Chromatography Today 735 946 .
D. B. Campbell. (1990) Stereoselectivity in clinical pharmacokinetics and drug development. European Journal of Drug Metabolism and Pharmacokinetics 15:2, pages 109-125.
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S. Alessi-Severini, F. Jamali, F.M. Pasutto, R.T. Coutts & S. Gulamhusein. (1990) High-Performance Liquid Chromatographic Determination of the Enantiomers of Flecainide in Human Plasma and Urine. Journal of Pharmaceutical Sciences 79:3, pages 257-260.
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Jacques Turgeon, Heyo K. Kroemer, Chandra Prakash, Ian A. Blair & Dan M. Roden. (1990) Stereoselective Determination of Flecainide in Human Plasma by High-Performance Liquid Chromatography with Fluorescence Detection. Journal of Pharmaceutical Sciences 79:2, pages 91-95.
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Harumi Takahashi, Akihiro Tamura, Hiroyasu Ogata & Keiso Masuhara. (1990) Simultaneous determination of disopyramide and its mono-N-dealkylated metabolite enantiomers in human plasma and urine by enantioselective high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 529, pages 347-358.
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Elfriede Nusser, Karl Nill & Ursula Breyer-Pfaff. (1990) Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. Journal of Chromatography B: Biomedical Sciences and Applications 528, pages 163-171.
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Roger L. Nation. (2007) ENANTIOSELECTIVE DRUG ANALYSIS: PROBLEMS AND RESOLUTIONS. Clinical and Experimental Pharmacology and Physiology 16:6, pages 471-477.
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Nuggehally R. Srinivas, John K. Cooper, John W. Hubbard & Kamal K. Midha. (1989) Isothermal capillary gas chromatography with electron-capture detection of heptafluorobutyryl-l-prolyl derivatives of chiral amphetamines. Journal of Chromatography B: Biomedical Sciences and Applications 491, pages 262-264.
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Chandra Prakash, Hemant K. Jajoo, Ian A. Blair & Robert F. Mayol. (1989) Resolution of enantiomers of the antiarrhythmic drug encainide and its major metabolites by chiral derivatization and high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 493, pages 325-335.
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Andre Weil, John Caldwell, Jean‐Pierre Guichard & Gerard Picot. (2004) Species differences in the chirality of the carbonyl reduction of [ 14 C] fenofibrate in laboratory animals and humans . Chirality 1:3, pages 197-201.
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Harumi Takahashi, Satoshi Kanno, Hiroyasu Ogata, Kazuko Kashiwada, Mineko Ohira & Kazuhiko Someya. (1988) Determination of Propranolol Enantiomers in Human Plasma and Urine and in Rat Tissues Using Chiral Stationary-Phase Liquid Chromatography. Journal of Pharmaceutical Sciences 77:11, pages 993-995.
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Michael J. Avram & Thomas K. Henthorn. (1988) What’s New in Pharmacokinetics and Pharmacodynamics?. Anesthesiology Clinics of North America 6:2, pages 251-280.
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Nobuo Inotsume, Junko Fujii, Mikiko Honda, Masahiro Nakano, Akimasa Higashi & Ichiro Matsuda. (1988) Stereoselective analysis of the enantiomers of ethotoin in human serum using chiral stationary phase liquid chromatography and gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 428, pages 402-407.
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A. Sioufi, G. Kaiser, F. Leroux & J.P. Dubois. (1988) Determination of the S(+)- and R(−)-enantiomers of baclofen in plasma and urine by gas chromatography using a chiral fused-silica capillary column and an electron-capture detector. Journal of Chromatography A 450:2, pages 221-232.
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E. Delee, I. Jullien & L. Le Garrec. (1988) Direct high-performance liquid chromatographic resolution of dihydropyridine enantiomers. Journal of Chromatography A 450:2, pages 191-197.
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E. Delee, I. Jullien, L. Le Garrec, A. Loupy, J. Sansoulet & A. Zaparucha. (1988) Chiral michael additions of acetamidomalonate to α-enones. Journal of Chromatography A 450:2, pages 183-189.
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H. Spahn. (1988) S-(+)-Flunoxaprofen chloride as chiral fluorescent reagent. Journal of Chromatography B: Biomedical Sciences and Applications 427, pages 131-137.
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John Caldwell, Andrew J. Hutt & Sylvie Fournel-Gigleux. (1988) The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences. Biochemical Pharmacology 37:1, pages 105-114.
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John Caldwell, John F. Derbyshire, Steven M. Winter & Andrew J. Hutt. 1988. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular 257 261 .
Karla G. Feitsma, Ben F. H. Drenth & Rokus A. de Zeeuw. 1988. Chiral Separations. Chiral Separations 37 41 .
T. K. Gerding, B. F. H. Drenth & R. A. de Zeeuw. (2005) Separation of N‐0437 enantiomers by RP‐HPLC after pre‐column derivatization with D(+)‐glucuronic acid. Journal of High Resolution Chromatography 10:9, pages 523-525.
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A. E. Balant-Gorgia, L. P. Balant, M. Gex-Fabry & Ch. Genet. (1987) Stereoselective disposition of flupentixol: influence on steady state plasma concentrations in schizophrenic patients. European Journal of Drug Metabolism and Pharmacokinetics 12:2, pages 123-128.
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Yoji Tokuma, Tomoichi Fujiwara & Hideyo Noguchi. (1987) Determination of (+)- and (−)-Nilvadipine in Human Plasma Using Chiral Stationary-Phase Liquid Chromatography and Gas Chromatography-Mass Spectrometry, and a Preliminary Pharmacokinetic Study in Humans. Journal of Pharmaceutical Sciences 76:4, pages 310-313.
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A. Avgerinos & A.J. Hutt. (1987) Determination of the enantiomeric composition of ibuprofen in human plasma by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 415, pages 75-83.
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J. Caldwell & A. J. Hutt. 1987. Side-Effects of Anti-Inflammatory Drugs. Side-Effects of Anti-Inflammatory Drugs 217 228 .

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