Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 3
Submit an article Journal homepage
13
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Peroxidative N-oxidation and N-dealkylation reactions of pargyline

A. M. Weli Department of Organic Pharmaceutical Chemistry, Biomedical Center, University of Uppsala, Box 574, S-751 23, Uppsala, Sweden
&
B. Lindeke Department of Organic Pharmaceutical Chemistry, Biomedical Center, University of Uppsala, Box 574, S-751 23, Uppsala, Sweden
Pages 281-288 | Received 21 Mar 1985, Published online: 22 Sep 2008

Citations (18)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
Read now
Peter Hlavica. (1994) Regulatory Mechanisms in the Activation of Nitrogenous Compounds by Mammalian Cytochrome P-450 Isozymes. Drug Metabolism Reviews 26:1-2, pages 325-348.
Read now
M. Štefek & L. Beneš. (1989) Hydrogen Peroxide-Dependent Liver Microsomal N-Demethylation and N-Oxygenation of Stobadine, a γ-Carboline Antiarrhythmic and Cardioprotective Agent. Xenobiotica 19:6, pages 627-634.
Read now

Articles from other publishers (15)

C. Sloby. 2019. Catalysis from A to Z. Catalysis from A to Z.
Judith A. Egan & Crist N. Filer. (2014) Tritiation and characterization of several suicide substrate enzyme inactivators. Applied Radiation and Isotopes 94, pages 302-305.
Crossref
Nilesh W. Gaikwad & William J. Bodell. (2012) Peroxidase-mediated dealkylation of tamoxifen, detected by electrospray ionization–mass spectrometry, and activation to form DNA adducts. Free Radical Biology and Medicine 52:2, pages 340-347.
Crossref
Erin M. MacKenzie, Afshin Fassihi, Asghar Davood, Qiao-Hong Chen, Gillian Rauw, Gail Rauw, Edward E. Knaus & Glen B. Baker. (2008) N-Propynyl analogs of β-phenylethylidenehydrazines: Synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase. Bioorganic & Medicinal Chemistry 16:17, pages 8254-8263.
Crossref
Ferenc Lévai, Erzsébet Fejér, Gábor Szeleczky, Anna Szabó, Tünde Erős-Takácsy, Félix Hajdu, Gyula Szebeni, István Szatmári & István Hermecz. (2004) In vitro formation of selegiline-N-oxide as a metabolite of selegiline in human, hamster, mouse, rat, guinea-pig, rabbit and dog. European Journal of Drug Metabolism and Pharmacokinetics 29:3, pages 169-178.
Crossref
Majid Y Moridani, Sumsullah Khan, Tom Chan, Shirley Teng, Kristin Beard & Peter J O'Brien. (2001) Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity. Chemico-Biological Interactions 130-132, pages 931-942.
Crossref
G. B. Baker, L. J. Urichuk, K. F. McKenna & S. H. Kennedy. (1999) Metabolism of Monoamine Oxidase Inhibitors. Cellular and Molecular Neurobiology 19:3, pages 411-426.
Crossref
Mark R. Hadley, Harriet G. Oldham, Patrick Camilleri, Lyaquatali A. Damani & Andrew J. Hutt. (1996) Species differences in the stereoselectivity ofN-oxygenation ofN-ethyl-N-methylaniline in vitro. Chirality 8:6, pages 430-440.
Crossref
Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
Crossref
A. J. Hutt, M. R. Hadley & S. C. Tan. (1994) Enantiospecific analysis: Applications in bioanalysis and metabolism. European Journal of Drug Metabolism and Pharmacokinetics 19:3, pages 241-251.
Crossref
Mark R. Hadley, Emil Švajdlenka, Lyaquatali A. Damani, Harriet G. Oldham, Jeanette Tribe, Patrick Camilleri & Andrew J. Hutt. (2004) Species variability in the stereoselective N ‐oxidation of pargyline . Chirality 6:2, pages 91-97.
Crossref
Peter Hlavica & Ute Künzel-Mulas. (1993) Metabolic N-oxide formation by rabbit-liver microsomal cytochrome P-4502B4: involvement of superoxide in the NADPH-dependent N-oxygenation of N,N-dimethylaniline. Biochimica et Biophysica Acta (BBA) - General Subjects 1158:1, pages 83-90.
Crossref
Glen B. Baker & Ronald T. Coutts. (1989) Metabolism of monoamine oxidase inhibitors. Progress in Neuro-Psychopharmacology and Biological Psychiatry 13:3-4, pages 395-403.
Crossref
Glen B. Baker, Ronald T. Coutts, Tadimeti S. Rao, T. W. Eric Hall & Ronald G. Micetich. 1988. Trace Amines. Trace Amines 321 334 .
T.S. Rao, G.B. Baker & R.T. Coutts. (1987) N, N-dipropargyl-2-phenylethylamine, a potential prodrug of 2-phenylethylamine: Neurochemical and neuropharmacological studies in rat. Brain Research Bulletin 19:1, pages 47-55.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.