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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 4
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Research Article

3,3′,4,4′-Tetrachloro[14C]biphenyl in pregnant mice: enrichment of phenol and methyl sulphone metabolites in late gestational fetuses

P. O. Darnerud Department of Pharmacology and Toxicology, SLU, Uppsala Biomedical Centre, Box 573, S-751 23, Uppsala, Sweden
,
I. Brandt Department of Pharmacology and Toxicology, SLU, Uppsala Biomedical Centre, Box 573, S-751 23, Uppsala, Sweden
,
E. Klasson-Wehler Section of Organic Chemistry, Wallenberg Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden
,
Å. Bergman Section of Organic Chemistry, Wallenberg Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden
,
R. D'argy Department of Toxicology, University of Uppsala, Uppsala Biomedical Centre, Box 594 and 572, S-751 23, Uppsala, Sweden
,
L. Dencker Department of Toxicology, University of Uppsala, Uppsala Biomedical Centre, Box 594 and 572, S-751 23, Uppsala, Sweden
&
G. O. Sperber Department of Medical Physiology, University of Uppsala, Uppsala Biomedical Centre, Box 594 and 572, S-751 23, Uppsala, Sweden
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Pages 295-306 | Received 01 May 1985, Published online: 22 Sep 2008

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D. C. Morse, P. J. Van Bladeren, E. Klasson Wehler & A. Brouwer. (1995) β-Naphthoflavone- and self-induced metabolism of 3,3′,4,4′-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat. Xenobiotica 25:3, pages 245-260.
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T. Sinjari, U. Törnwall & P. O. Darnerud. (1993) Induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in mice foetuses by the PCB-congener 3,3′,4,4′-tetrachlorobiphenyl. Xenobiotica 23:2, pages 107-114.
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D. H. Rouvray & W. Tatong. (1989) Novel applications of topological indices. 3. prediction of the vapor pressure in polychlorinated biphenyls. International Journal of Environmental Studies 33:4, pages 247-257.
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N. Koga, M. Beppu, C. Ishida & H. Yoshimura. (1989) Further studies on metabolism in vivo of 3,4,3′,4′-tetrachlorobiphenyl in rats: Identification of minor metabolites in rat faeces. Xenobiotica 19:11, pages 1307-1318.
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E. Klasson-wehler, Å. Bergman, B. Kowalski & I. Brandt. (1987) Metabolism of 2,3,4′,6-tetrachlorobiphenyl: formation and tissue localization of mercapturic acid pathway metabolites in mice. Xenobiotica 17:4, pages 477-486.
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Ingvar Brandt. (1986) Metabolism-related Tissue-binding of Halogenated Hydrocarbons. Upsala Journal of Medical Sciences 91:3, pages 289-294.
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Articles from other publishers (36)

Guangshu Zhai, Hans-Joachim Lehmler & Jerald L. Schnoor. (2010) Identification of hydroxylated metabolites of 3,3′,4,4′-tetrachlorobiphenyl and metabolic pathway in whole poplar plants. Chemosphere 81:4, pages 523-528.
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Rong-biao ZHAO, Da-yu SUN, Shan FU, Xiao-fei WANG & Ru-song ZHAO. (2007) Bioconcentration kinetics of PCBs in various parts of the lifecycle of the tadpoles Xenopus laevis. Journal of Environmental Sciences 19:3, pages 374-384.
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Tina Malmberg, Maria Athanasiadou, Göran Marsh, Ingvar Brandt & Åke Bergman. (2005) Identification of Hydroxylated Polybrominated Diphenyl Ether Metabolites in Blood Plasma from Polybrominated Diphenyl Ether Exposed Rats. Environmental Science & Technology 39:14, pages 5342-5348.
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Maria Johansson, Niklas Johansson & Bert-Ove Lund. (2005) Xenobiotics and the Glucocorticoid Receptor: Additive Antagonistic Effects on Tyrosine Aminotransferase Activity in Rat Hepatoma Cells. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:4, pages 309-315.
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Astrid Roth-Härer, Hellmuth Lilienthal, Michael Bubser, Ulrich Kronthaler, William R. Mundy, Thomas R. Ward, Werner Schmidt, Hilke Winterhoff & Gerhard Winneke. (2001) Neurotransmitter concentrations and binding at dopamine receptors in rats after maternal exposure to 3,4,3′,4′-tetrachlorobiphenyl: the role of reduced thyroid hormone concentrations. Environmental Toxicology and Pharmacology 9:3, pages 103-115.
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Renee D White, Damian Shea, Jennifer J Schlezinger, Mark E Hahn & John J Stegeman. (2000) In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 126:3, pages 267-284.
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Ronald Eisler. 2000. Handbook of Chemical Risk Assessment. Handbook of Chemical Risk Assessment.
Robert J. Letcher, Eva Klasson-Wehler & Ake Bergman. 2000. Volume 3 Anthropogenic Compounds Part K. Volume 3 Anthropogenic Compounds Part K 315 359 .
Vincent J. Kramer & John P. Giesy. (1999) Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships. Science of The Total Environment 233:1-3, pages 141-161.
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Ingvar Brandt, Cecilia Berg, Krister Halldin & Björn Brunström. 1998. Diversification in Toxicology — Man and Environment. Diversification in Toxicology — Man and Environment 111 119 .
Daniel Desaulniers, Raymond Poon, Wendy Phan, Karen Leingartner, Warren G. Foster & IH Chu. (2016) Reproductive and Thyroid Hormone Levels in Rats Following 90-Day Dietary Exposure To Pcb 28 (2,4,4'-Trichlorobiphenyl) or Pcb 77 (3,3',4,4'-Tetrachlorobiphenyl). Toxicology and Industrial Health 13:5, pages 627-638.
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Pim E. G. Leonards, Yolanda Zierikzee, Udo A. Th. Brinkman, Wim P. Cofino, Nico M. van Straalen & Bert van Hattum. (2009) The selective dietary accumulation of planar polychlorinated biphenyls in the otter ( Lutra lutra ) . Environmental Toxicology and Chemistry 16:9, pages 1807-1815.
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Vincent J Kramer, William G Helferich, Åke Bergman, Eva Klasson-Wehler & John P Giesy. (1997) Hydroxylated Polychlorinated Biphenyl Metabolites Are Anti-estrogenic in a Stably Transfected Human Breast Adenocarcinoma (MCF7) Cell Line. Toxicology and Applied Pharmacology 144:2, pages 363-376.
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Per Ola Darnerud, Taha Sinjari & Curt‐Johan Jönsson. (2009) Foetal Uptake of Coplanar Polychlorinated Biphenyl (PCB) Congeners in Mice. Pharmacology & Toxicology 78:3, pages 187-192.
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Taha Sinjari, Eva Klasson‐Wehler, Agneta Oskarsson & Per Ola Darnerud. (2009) Milk Transfer and Neonatal Uptake of Coplanar Polychlorinated Biphenyl (PCB) Congeners in Mice. Pharmacology & Toxicology 78:3, pages 181-186.
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P.O. Darnerud, D. Morse, E. Klasson-Wehler & A. Brouwer. (1996) Binding of a 3,3′,4,4′-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. Toxicology 106:1-3, pages 105-114.
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Dennis C. Morse, Eva Klasson Wehler, Maribel van de Pas, Albert Th.H.J. de Bie, Peter J. van Bladeren & Abraham Brouwer. (1995) Metabolism and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl in pregnant and fetal rats. Chemico-Biological Interactions 95:1-2, pages 41-56.
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C. Rönnbäck & D. G. de Rooij. (2009) Effects of 3,3′,4,4′‐Tetrachlorobiphenyl on Foetal Germ Cells in Two Mouse Strains after Repeated Treatment of the Dams During and After Pregnancy. Pharmacology & Toxicology 74:6, pages 287-293.
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Albertinka Murk, Dennis Morse, Jan Boon & Abraham Brouwer. (1994) In vitro metabolism of 3,3′,4,4′-tetrachlorobiphenyl in relation to ethoxyresorufin-O-deethylase activity in liver microsomes of some wildlife species and rat. European Journal of Pharmacology: Environmental Toxicology and Pharmacology 270:2-3, pages 253-261.
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E.B. Brittebo, A.Å. Karlsson, K.I. Skog & I.M. Jägerstad. (1994) Transfer of the food mutagen PhIP to foetuses and newborn mice following maternal exposure. Food and Chemical Toxicology 32:8, pages 717-726.
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P.O. Darnerud, U. Törnwall, Å. Bergman & I. Brandt. (1993) Liver accumulation of 2,3,7,8-tetrachloro-[3H]dibenzofuran in mice: modulation by treatments with polychlorinated biphenyls. Chemico-Biological Interactions 89:2-3, pages 89-102.
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Seija Sinkkonen. (1993) Environmental analysis of chlorinated aromatic thioethers, sulphoxides and sulphones. Journal of Chromatography A 642:1-2, pages 47-52.
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David E. Wells. 1993. Environmental Analysis Techniques, Applications and Quality Assurance. Environmental Analysis Techniques, Applications and Quality Assurance 113 148 .
C.H. WALKER. 1992. Persistent Pollutants in Marine Ecosystems. Persistent Pollutants in Marine Ecosystems 211 232 .
T. R. Narasimhan, H. L. Kim & S. H. Safe. (2006) Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation. Journal of Biochemical Toxicology 6:3, pages 229-236.
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Curt Rönnbäck. (2009) Effects of 3,3′,4,4′‐Tetrachlorobiphenyl (TCB) on Ovaries of Foetal Mice. Pharmacology & Toxicology 68:5, pages 340-345.
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C.H. Walker. (1990) Persistent pollutants in fish-eating sea birds — bioaccumulation, metabolism and effects. Aquatic Toxicology 17:4, pages 293-324.
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A. Browuer, E. Klasson-Wehler, M. Bokdam, D.C. Morse & W.A. Traag. (1990) Competitive inhibition of thyroxin binding to transihyretin by monohy-droxy metabolites of 3,4,3′,4′-tetrachlorobiphenyl. Chemosphere 20:7-9, pages 1257-1262.
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E. Klasson Wehler, B. Brunström, U. Rannug & Å. Bergman. (1990) 3,3′,4,4′-Tetrachlorobiphenyl: Metabolism by the chick embryo in ovo and toxicity of hydroxylated metabolites. Chemico-Biological Interactions 73:1, pages 121-132.
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Linda Sargent, Boyd Roloff & Lorraine Meisner. (1989) In vitro chromosome damage due to PCB interactions. Mutation Research/Genetic Toxicology 224:1, pages 79-88.
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RICHARD E. MORRISSEY & BERNARD A. SCHWETZ. 1989. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products 195 225 .
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MICHAEL GILBERTSON. 1989. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products 103 127 .
E. Klasson Wehler, J. Jönsson, Å. Bergman, I. Brandt & P.O. Darnerud. (1989) 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′,5-pentachlorobiphenyl-tissue-localization and metabolic fate in the mouse. Chemosphere 19:1-6, pages 809-812.
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R. D'Argy, L. Dencker, E. Klasson‐Wehler, Å. Bergman, P. O. Darnerud & I. Brandt. (2009) 3,3′,4,4′‐Tetrachlorobiphenyl in Pregnant Mice: Embryotoxicity, Teratogenicity, and Toxic Effects on the Cultured Embryonic Thymus. Pharmacology & Toxicology 61:1, pages 53-57.
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Ingvar Brandt & Åke Bergman. (1987) PCB methyl sulphones and related compounds: identification of target cells and tissues in different species. Chemosphere 16:8-9, pages 1671-1676.
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