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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 4
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Research Article

The metabolism of nicardipine hydrochloride in healthy male volunteers

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Pages 341-349 | Received 18 Apr 1985, Published online: 22 Sep 2008

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BhupendrasinhK. Vaghela & Surendra Singh Rao. (2013) IDENTIFICATION AND CHARACTERIZATION OF A NOVEL POTENTIAL DEGRADANT AND DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-LC METHOD FOR NICARDIPINE IMPURITIES IN INJECTABLE DOSAGE FORM. Journal of Liquid Chromatography & Related Technologies 36:15, pages 2166-2181.
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Pao-Chu Wu, Yei-Huan Lin, Jui-Sheng Chang, Yaw-Bin Huang & Yi-Hung Tsai. (2010) The effect of component of microemulsion for transdermal delivery of nicardipine hydrochloride. Drug Development and Industrial Pharmacy 36:12, pages 1398-1403.
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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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H. Nakabeppu, M. Asada, T. Oda, Y. Shinozaki & T. Yajima. (1996) Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica 26:2, pages 229-239.
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S. Terashita, Y. Tokuma, M. Sekiguchi & H. Noguchi. (1989) Sex differences in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats. Xenobiotica 19:11, pages 1221-1229.
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A. P. Beresford, D. McGibney, M. J. Humphrey, P. V. Macrae & D. A. Stopher. (1988) Metabolism and kinetics of amlodipine in man. Xenobiotica 18:2, pages 245-254.
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S. Terashita, Y. Tokuma, T. Fujiwara, Y. Shiokawa, K. Okumura & H. Noguchi. (1987) Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 17:12, pages 1415-1425.
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Sergey Shityakov & Carola Förster. (2013) Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins Using Two-Compartment Mathematical Model. The Scientific World Journal 2013, pages 1-9.
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Toshiro Niwa, Shinji Honda, Kiyoharu Shirakawa, Yasushi Imamura, Sadayuki Osaki & Akira Takagi. (2006) Drug interaction of fluvoxamine, a selective serotonin reuptake inhibitor. Folia Pharmacologica Japonica 128:2, pages 93-103.
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Xiao-fei Zhou, Joan MacDiarmid, Robert A. Coburn & Marilyn E. Morris. (2005) Pharmacokinetics and bioavailability of a newly synthesized dihydropyridine compound with multidrug resistance reversal activity. Biopharmaceutics & Drug Disposition 26:7, pages 279-285.
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M. E. Letelier, P. Izquierdo, L. Godoy, A. M. Lepe & M. Faúndez. (2004) Liver microsomal biotransformation of nitro‐aryl drugs: mechanism for potential oxidative stress induction. Journal of Applied Toxicology 24:6, pages 519-525.
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M. Stefek, V. Faberova, S. Musil & I. Kakalik. (2001) Urinary excretion of the 1,4-dihydropyridine calcium antagonist VULM 993 and its metabolites in the rat. European Journal of Drug Metabolism and Pharmacokinetics 26:4, pages 221-226.
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Toshiharu Sakai, Toshio Teramura, Hideaki Okamiya & Osamu Inagaki. (2007) A Review on Barnidipine: A Novel Calcium Antagonist. Cardiovascular Drug Reviews 15:4, pages 273-290.
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S.M. Khedun, J. Moodley, T. Naicker & B. Maharaj. (1997) Drug management of hypertensive disorders of pregnancy. Pharmacology & Therapeutics 74:2, pages 221-258.
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P. A. Soons, T. M. T. Mulders, E. Uchida, H. C. Schoemaker, A. F. Cohen & D. D. Breimer. (1993) Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics. European Journal of Clinical Pharmacology 44:2, pages 163-169.
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Yumi Ohtake, Takashi Sakamoto, Ryota Nishioka, Kazuo Uno & Shigeru Tabata. (2012) Metabolic Fate of Felodipine in Man. Drug Investigation 4:6, pages 528-534.
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Margareth Gabrielsson, Kurt-Jürgen Hoffmann & Carl Gunnar Regårdh. (1992) Determination of four carboxylic acid metabolites of felodipine in plasma by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 573:2, pages 265-274.
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JH Ahmed, AC Grant, RS Rodger, GR Murray & HL Elliott. (2012) Inhibitory effect of uraemia on the hepatic clearance and metabolism of nicardipine.. British Journal of Clinical Pharmacology 32:1, pages 57-62.
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E. Fritschka, M. Claus & Th. Philipp. 1991. Kalziumantagonisten in Klinik und Praxis. Kalziumantagonisten in Klinik und Praxis 27 77 .
R.J. Eastwood, C. Galustian, R.K. Bhamra & D.W. Holt. (1990) High-performance liquid chromatographic method for the measurement of nicardipine in plasma or serum. Journal of Chromatography B: Biomedical Sciences and Applications 530, pages 463-468.
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S. Kazda & A. Knorr. 1990. Pharmacology of Antihypertensive Therapeutics. Pharmacology of Antihypertensive Therapeutics 301 375 .
T. Funaki, P.A. Soons, F.P. Guenoerich & D.D. Breimer. (1989) In vivo oxidative cleavage of a pyridinecarboxylic acid ester metabolite of nifedipine. Biochemical Pharmacology 38:23, pages 4213-4216.
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A. L. Burlingame, D. Maltby, D. H. Russell & P. T. Holland. (2002) Mass spectrometry. Analytical Chemistry 60:12, pages 294-342.
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R. J. DOW & D. J. M. GRAHAM. (1986) A review of the human metabolism and pharmacokinetics of nicardipine hydrochloride. British Journal of Clinical Pharmacology 22, pages 195S-202S.
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