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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 6
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Original Article

Metabolic N-Hydroxylation of substituted acetophenone ixnines. I. Evidence for formation of isomeric oximes

J. W. Gorrod Chelsea Department of Pharmacy, Kings College London (KQC), University of London, Manresa Road, Chelsea, London, SW3 6LX, UK
&
M. Christou Chelsea Department of Pharmacy, Kings College London (KQC), University of London, Manresa Road, Chelsea, London, SW3 6LX, UK; Department of Pharmacology, Medical Sciences Center, University of Wisconsin Medical School, Madison, WI, 53706, USA
Pages 575-585 | Received 12 Jul 1985, Published online: 30 Sep 2009

Citations (7)

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Read on this site (2)

J. W. Gorrod & M. Ulgen. (1994) Metabolic N-Oxidation of Diarylimines: A New Metabolic Reaction of Potential Toxicological Significance. Drug Metabolism Reviews 26:1-2, pages 241-252.
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J. G. Slatter, F. S. Abbott & R. Burton. (1990) Identification of the biliary metabolites of (±)-3-dimethylamino-1,1-diphenylbutane HC1 (recipavrin) in rats. Xenobiotica 20:10, pages 999-1024.
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Articles from other publishers (5)

Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Sabine Heberling, Ulrich Girreser, Stephanie Wolf & Bernd Clement. (2006) Oxygen-insensitive enzymatic reduction of oximes to imines. Biochemical Pharmacology 71:3, pages 354-365.
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M. Kajbaf, J.H. Lamb, S. Naylor, K. Pattichis & J.W. Gorrod. (1991) Identification of metabolites derived from the H2-receptor antagonist mifentidine using tandem mass spectrometry. Analytica Chimica Acta 247:2, pages 151-159.
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B. Clement. (1989) STRUCTURAL REQUIREMENTS OF MICROSOMAL N-OXYGENATIONS DERIVED FROM STUDIES ON AMIDINES. Drug Metabolism and Drug Interactions 7:1.
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David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger W. Russell, L. Öhman, G. Maluszynska, K.-E. MAgnusson, O. Stendahl, Peter A. Lambert, David H. P. Streeten, Gunnar H. AndersonJrJr, Vickram Ramkumar, George Pierson, Gary L. Stiles, Bernard Testa, Joachm M. Mayer, Duncan Stewart-Tull, Michael Williams, Gary L. Niel, Peter Hambleton, Stephen D. Prior, Andrew Robinson, Jed F. Fisher & Paul A. AristoffBernard Testa & Joachim M. Mayer. 1988. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 249 303 .

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