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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 7
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Original Article

N-Methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosy1-L-methioninedependent reaction

L. A. Damani Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK
,
M. S. Shaker Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK
,
P. A. Crooks College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, 40536-0082, USA
,
C. S. Godin College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, 40536-0082, USA
&
C. Nwosu College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, 40536-0082, USA
Pages 645-650 | Received 16 Jul 1985, Accepted 24 Jan 1986, Published online: 30 Sep 2009

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Diansong Zhou, Minli Zhang, Xiaomei Ye, Chungang Gu, Timothy M. Piser, Bernard A. Lanoue, Sara A. Schock, Yi-Fang Cheng & Scott W. Grimm. (2011) In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite. Xenobiotica 41:3, pages 232-242.
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Articles from other publishers (10)

S. Cyrus Khojasteh, Qin Yue, Shuguang Ma, Georgette Castanedo, Jacob Z Chen, Joseph Lyssikatos, Teresa Mulder, Ryan Takahashi, Justin Ly, Kirsten Messick, Wei Jia, Lichuan Liu, Cornelis E. C. A. Hop & Harvey Wong. (2014) Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib. Drug Metabolism and Disposition 42:3, pages 343-351.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 19 .
Karen L. Ericson, Vincent M. Maloney, J. Dennis Mahuren, Stephen P. Coburn & Thorsten P. Degenhardt. (2008) N-Methylpyridoxamine: Novel canine vitamin B6 urine metabolite. Bioorganic & Medicinal Chemistry Letters 18:6, pages 1845-1848.
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. 2006. Class 2 · Transferases I. Class 2 · Transferases I 452 453 .
Hugo M. Vargas & Donald J. Jenden. (1996) Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N1-methylnicotinamide in brain tissue. Life Sciences 58:22, pages 1995-2002.
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. 1992. Enzyme Nomenclature. Enzyme Nomenclature 576 727 .
RALPH L. REED. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 259 267 .
Edwin C. WEBB. (1989) Enzyme Nomenclature. Recommendations 1984. Supplement 2: corrections and additions. European Journal of Biochemistry 179:3, pages 489-533.
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Barbara Upmeier, Wildtrud Gross, Susanne Ko¨ster & Wolfgang Barz. (1988) Purification and properties of S-adenosyl-l-methionine:Nicotinic acid-N-methyltransferase from cell suspension cultures of Glycine max L.. Archives of Biochemistry and Biophysics 262:2, pages 445-454.
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C.Steven Godin, Peter A. Crooks & Lyaquatali A. Damani. (1986) N-methylation of phenylpyridines and bispyridyls as a potential toxication route: Tissue distribution of azaheterocycle n-methyltransferase activity in the rabbit. Toxicology Letters 34:2-3, pages 217-222.
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