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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 7
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Original Article

Metabolism of methapyrilene by rat-liver homogenatc

R. C. Kammerer Department of Phamacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, California, 90024, USA
&
D. A. Schmitz Department of Phamacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, California, 90024, USA
Pages 671-680 | Received 13 Aug 1985, Published online: 30 Sep 2009

Citations (8)

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D. W. Kelly, C. L. Holder, W. A. Korfmacher, T. A. Getek, J. O. Lay, D. A. Casciano, J. G. Shaddock, H. M. Duhart & W. Slikker. (1992) Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. Xenobiotica 22:12, pages 1367-1381.
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M. A. Lampe & R. C. Kammerer. (1990) Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster. Xenobiotica 20:12, pages 1269-1280.
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R. Craig Kammerer & Debra A. Schmitz. (1988) A Comparativel in Vitro Metabolic Study of Methaphenilene and Pyribenzamine. Xenobiotica 18:9, pages 1085-1096.
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R. Craig Kammerer, Debra A. Schmitz, Marilyn A. Lampe & Kenneth Kloc. (1988) The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. Xenobiotica 18:7, pages 869-881.
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R. Craig Kammerer & Debra A. Schmitz. (1987) Species differences in the in vitro metabolism of methapyrilene. Xenobiotica 17:9, pages 1121-1130.
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Articles from other publishers (3)

Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams & B. Kevin Park. (2008) Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. Journal of Pharmacology and Experimental Therapeutics 326:2, pages 657-671.
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Gurpreet S Ratra, Winston A Morgan, Jenny Mullervy, Christopher J Powell & Matthew C Wright. (1998) Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. Toxicology 130:2-3, pages 79-93.
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R.C. Kammerer, J.R. Froines & T. Price. (1986) Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food and Chemical Toxicology 24:9, pages 981-985.
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