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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 8
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Research Article

Isolation and identification of metabolites of ofloxacin in rats, dogs and monkeys

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Pages 725-732 | Received 22 Aug 1985, Published online: 22 Sep 2008

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A. Hemeryck, R. N. V. S. Mamidi, M. Bottacini, D. Macpherson, M. Kao & M. F. Kelley. (2006) Pharmacokinetics, metabolism, excretion and plasma protein binding of 14C-levofloxacin after a single oral administration in the Rhesus monkey. Xenobiotica 36:7, pages 597-613.
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O. Okazaki, T. Kurata, H. Hakusui & H. Tachizawa. (1992) Species-related stereoselective disposition of ofloxacin in the rat, dog and monkey. Xenobiotica 22:4, pages 439-450.
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O. Okazaki, T. Kurata & H. Tachizawa. (1989) Stereoselective Metabolic Disposition of Enantiomers of Ofloxacin in Rats. Xenobiotica 19:4, pages 419-429.
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Articles from other publishers (20)

Shuyao Wang, Chun Chen, Chi Guan, Liping Qiu, Lei Zhang, Shaofeng Zhang, Hongyu Zhou, Hongwen Du, Chen Li, Yaqiong Wu, Hang Chang & Tao Wang. (2021) Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology Research & Perspectives 9:5.
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Ravindra D. Yeole, Vipul P. Rane, Vinod K. Ahirrao, Rajesh P. Chavan, Anasuya M. Patel, Prasad K. Deshpande, Mahesh V. Patel & Kiran R. Patil. (2019) Identification of metabolites of novel Anti‐MRSA fluoroquinolone WCK 771 in mouse, rat, rabbit, dog, monkey and human urine using liquid chromatography tandem mass spectrometry. Biomedical Chromatography 33:7, pages e4532.
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Marina Rusch, Astrid Spielmeyer, Jessica Meißner, Manfred Kietzmann, Holger Zorn & Gerd Hamscher. (2017) Efficient Reduction of Antibacterial Activity and Cytotoxicity of Fluoroquinolones by Fungal-Mediated N -Oxidation . Journal of Agricultural and Food Chemistry 65:15, pages 3118-3126.
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Jinsong Ni, Hui Ouyang, Carmai Seto, Takeo Sakuma, Robert Ellis, Josh Rowe, Andrew Acheampong, Devin Welty & Gabriella Szekely-Klepser. (2010) Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC–MS/MS. Bioanalysis 2:3, pages 407-419.
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C. Carlesi Jara, D. Fino, V. Specchia, G. Saracco & P. Spinelli. (2007) Electrochemical removal of antibiotics from wastewaters. Applied Catalysis B: Environmental 70:1-4, pages 479-487.
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Premasis Sukul & Michael Spiteller. 2007. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 131 162 .
Igor A. Parshikov, James P. Freeman, Jackson O. LayJr.Jr., Richard D. Beger, Anna J. Williams & John B. Sutherland. (2000) Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus . Applied and Environmental Microbiology 66:6, pages 2664-2667.
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K. YOSHIDA, K. YABE, S. NISHIDA, N. YAMAMOTO, C. OHSHIMA, M. SEKIGUCHI, K. YAMADA & K. FURUHAMA. (2002) Pharmacokinetic disposition and arthropathic potential of oral ofloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics 21:2, pages 128-132.
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István Hermecz. 1998. Advances in Heterocyclic Chemistry Volume 71. Advances in Heterocyclic Chemistry Volume 71 145 289 .
. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 1169 1326 .
István Hermecz, Lelle Vasvári-Debreczy & Péter Mátyus. 1996. Comprehensive Heterocyclic Chemistry II. Comprehensive Heterocyclic Chemistry II 563 595 .
Paul A. D'Agostino, James R. Hancock & Lionel R. Provost. (2005) Electrospray mass spectrometric characterization of fluoroquinolone antibiotics: Norfloxacin, enoxacin, ciprofloxacin and ofloxacin. Rapid Communications in Mass Spectrometry 9:11, pages 1038-1043.
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T.B. Vree, E.W.J. van Ewijk-Beneken Kolmer & J.F.M. Nouws. (1992) Direct-gradient high-performance liquid chromatographic analysis and preliminary pharmacokinetics of flumequine and flumequine acyl glucuronide in humans: effect of probenecid. Journal of Chromatography B: Biomedical Sciences and Applications 579:1, pages 131-141.
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Alec W. Gough, Olajide B. Kasali, Robert E. Sigler & Vijaykumar Baragi. (2016) Review Article: Quinolone Arthropathy—Acute Toxicity to Immature Articular Cartilage. Toxicologic Pathology 20:3-1, pages 436-449.
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O OkazakiC KojimaH HakusuiM Nakashima. (1991) Enantioselective disposition of ofloxacin in humans. Antimicrobial Agents and Chemotherapy 35:10, pages 2106-2109.
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R. Stahlmann, H. J. Merker, N. Hinz, I. Chahoud, J. Webb, W. Heger & D. Neubert. (1990) Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations. Archives of Toxicology 64:3, pages 193-204.
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Ayla Tamer. (1990) Adsorptive stripping voltammetric determination of ofloxacin. Analytica Chimica Acta 231, pages 129-131.
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Rüdiger Warlich & Ernst Mutschler. (1989) Thin-layer chromatographic separation and in situ fluorimetric determination of ofloxacin in plasma and pleural fluid. Journal of Chromatography B: Biomedical Sciences and Applications 490, pages 395-403.
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Richard B. Van Breemenm, Martin Stogniew & Catherine Fenselau. (1988) Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry. Biological Mass Spectrometry 17:2, pages 97-103.
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A. L. Burlingame, D. Maltby, D. H. Russell & P. T. Holland. (2002) Mass spectrometry. Analytical Chemistry 60:12, pages 294-342.
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