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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 8
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Research Article

The metabolism of 14C-oxcarbazepine in man

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Pages 769-778 | Received 07 Jan 1986, Published online: 22 Sep 2008

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Yue-Ting Chen, Chen-Yu Wang, Yi-Wei Yin, Zi-Ran Li, Wei-Wei Lin, Min Zhu & Zheng Jiao. (2021) Population pharmacokinetics of oxcarbazepine: a systematic review. Expert Review of Clinical Pharmacology 14:7, pages 853-864.
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Ricardo Blanco-Castañeda, Carlos Galaviz-Hernández, Paula C. S. Souto, Victor Vitorino Lima, Fernanda R. Giachini, Carlos Escudero, Alicia E Damiano, L. Jazel Barragán-Zúñiga, Gerardo Martínez-Aguilar & Martha Sosa-Macías. (2020) The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field. Expert Review of Clinical Pharmacology 13:3, pages 247-263.
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Alberto Verrotti, Giulia Iapadre, Giulia Di Donato, Ludovica Di Francesco, Luca Zagaroli, Sara Matricardi, Vincenzo Belcastro & Maria Laura Iezzi. (2019) Pharmacokinetic considerations for anti-epileptic drugs in children. Expert Opinion on Drug Metabolism & Toxicology 15:3, pages 199-211.
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Peter Stopfer, Karin Rathgen, Daniel Bischoff, Silke Lüdtke, Kristell Marzin, Rolf Kaiser, Klaus Wagner & Thomas Ebner. (2011) Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica 41:4, pages 297-311.
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Bernhard J Steinhoff. (2009) Oxcarbazepine extended-release formulation in epilepsy. Expert Review of Clinical Pharmacology 2:2, pages 155-162.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Paul Whiteley & Paul Shattock MRPharmS. (2003) What Makes Trans‐indolyl‐3‐acryloylglycine Identified by High‐performance Liquid Chromatography Relevant to Pervasive Developmental Disorders?. Journal of Nutritional & Environmental Medicine 13:4, pages 231-237.
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Ahmad Beydoun & Ekrem Kutluay. (2002) Oxcarbazepine. Expert Opinion on Pharmacotherapy 3:1, pages 59-71.
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Steven C Schachter. (1999) Oxcarbazepine: current status and clinical applications. Expert Opinion on Investigational Drugs 8:7, pages 1103-1112.
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Luis Almeida & Patrício Soares-da-Silva. (2004) Safety, Tolerability, and Pharmacokinetic Profile of BIA 2-093, a Novel Putative Antiepileptic, in a Rising Multiple-Dose Study in Young Healthy Humans. The Journal of Clinical Pharmacology 44:8, pages 906-918.
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E. Faught. 2004. The Treatment of Epilepsy. The Treatment of Epilepsy 451 460 .
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Jarogniew J. Luszczki, Kinga K. Borowicz, Mariusz Swiader & Stanislaw J. Czuczwar. (2003) Interactions Between Oxcarbazepine and Conventional Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis. Epilepsia 44:4, pages 489-499.
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Donald J. AbrahamKenneth R. Scott. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 263 328 .
Luis Almeida & Patr??cio Soares-da-Silva. (2003) Safety, Tolerability and Pharmacokinetic Profile of BIA 2-093, a Novel Putative Antiepileptic Agent, during First Administration to Humans. Drugs in R & D 4:5, pages 269-284.
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Steven C. Schachter. (2001) Epilepsy. Neurologic Clinics 19:1, pages 57-78.
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Steven C. Schachter. (2000) The Next Wave of Anticonvulsants. CNS Drugs 14:3, pages 229-249.
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James C. Cloyd & Rory P. Remmel. (2012) Antiepileptic Drug Pharmacokinetics and Interactions: Impact on Treatment of Epilepsy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 20:8P2.
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A. BeydounR.C. SachdeoW.E. RosenfeldG.L. KraussN. SesslerP. MesenbrinkL. KramerJ. D’Souza. (2000) Oxcarbazepine monotherapy for partial-onset seizures. Neurology 54:12, pages 2245-2251.
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Andrew Volosov, Meir Bialer, Sun Xiaodong, Emilio Perucca, Amnon Sintov & Boris Yagen. (2000) Simultaneous stereoselective high-performance liquid chromatographic determination of 10-hydroxycarbazepine and its metabolite carbamazepine-10,11-trans-dihydrodiol in human urine. Journal of Chromatography B: Biomedical Sciences and Applications 738:2, pages 419-425.
Crossref
John M. Pellock & Lawrence D. Morton. (2000) Treatment of epilepsy in the multiply handicapped. Mental Retardation and Developmental Disabilities Research Reviews 6:4, pages 309-323.
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Jan Benes, António Parada, Anabela A. Figueiredo, Paula C. Alves, Ana P. Freitas, David A. Learmonth, Rodrigo A. Cunha, José Garrett & Patrício Soares-da-Silva. (1999) Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5 H -dibenz[ b , f ]azepine-5-carboxamide Derivatives . Journal of Medicinal Chemistry 42:14, pages 2582-2587.
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Andrew Volosov, Amnon Sintov & Meir Bialer. (1999) Stereoselective Pharmacokinetic Analysis of the Antiepileptic 10-Hydroxycarbazepine in Dogs. Therapeutic Drug Monitoring 21:2, pages 219-223.
Crossref
P Myllynen, P Pienimäki, H Raunio & K Vähäkangas. (2016) Microsomal metabolism of carbamazepine and oxcarbazepine in liver and placenta. Human & Experimental Toxicology 17:12, pages 668-676.
Crossref
P. Pienimäki, E. Lampela, J. Hakkola, P. Arvela, H. Raunio & K. Vähäkangas. (2005) Pharmacokinetics of Oxcarbazepine and Carbamazepine in Human Placenta. Epilepsia 38:3, pages 309-316.
Crossref
S. I. Johannessen. (1997) Pharmacokinetics and Interaction Profile of Topiramate: Review and Comparison with Other Newer Antiepileptic Drugs. Epilepsia 38:s1, pages S18-S23.
Crossref
Lennart Gram. (1996) Pharmacokinetics of New Antiepileptic Drugs. Epilepsia 37:s6, pages S12-S16.
Crossref
Emilio Perucca. (1996) Pharmacokinetic Profile of Topiramate in Comparison with Other New Antiepileptic Drugs. Epilepsia 37:s2, pages S8-S13.
Crossref
Katariina Castrén, Päivi Pienimäki, Pentti Arvela & Kirsi Vähäkangas. (2016) Metabolites and DNA-binding of carbamazepine and oxcarbazepine in vitro by rat liver microsomes. Human & Experimental Toxicology 15:7, pages 577-582.
Crossref
J.W. Britton & E.L. So. (1995) New antiepileptic drugs: Prospects for the future. Journal of Epilepsy 8:4, pages 267-281.
Crossref
P. Pienimäki, S. Fuchs, J. Isojärvi & K. Vähäkangas. (1995) Improved detection and determination of carbamazepine and oxcarbazepine and their metabolites by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 673:1, pages 97-105.
Crossref
K. M. Matar, P. J. Nicholls, M. I. Al–Hassan & A. Tekle. (1995) Rapid micromethod for simultaneous measurement of oxcarbazepine and its active metabolite in plasma by high–performance liquid chromatography. Journal of Clinical Pharmacy and Therapeutics 20:4, pages 229-234.
Crossref
P. Pienimäki, A.‐L. Hartikainen, P. Arvela, T. Partanen, R. Herva, O. Pelkonen & K. Vähäkangas. (2005) Carbamazepine and Its Metabolites in Human Perfused Placenta and in Maternal and Cord Blood. Epilepsia 36:3, pages 241-248.
Crossref
A. Sabers & L. Gram. (2011) Progress in the medical treatment of epilepsy: an overview of new antiepileptic drugs. European Journal of Neurology 1:3, pages 189-202.
Crossref
M.C. Walker & P.N. Patsalos. (1995) Clinical pharmacokinetics of new antiepileptic drugs. Pharmacology & Therapeutics 67:3, pages 351-384.
Crossref
George deStevens, V. Zingel, C. Leschke, W. Schunack, Paul D. Hoeprich, Richard M. Schultz, P. K. Mehrotra, Sanjay Batra, A. P. Bhaduri, Anil K. Saxena & Mridula SaxenaAnil K. Saxena & Mridula Saxena. 1995. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 185 291 .
Artur W. Wamil, Markus Schmutz, Chantal Portet, Karl F. Feldmann & Michael J. McLean. (1994) Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures. European Journal of Pharmacology 271:2-3, pages 301-308.
Crossref
M. Schmutz, F. Brugger, C. Gentsch, M. J. McLean & H. R. Olpe. (1994) Oxcarbazepine: Preclinical Anticonvulsant Profile and Putative Mechanisms of Action. Epilepsia 35:s5, pages S47-S50.
Crossref
M.C. Rouan, M. Decherf, V. Le Clanche, J.B. Lecaillon & J. Godbillon. (1994) Automated microanalysis of oxcarbazepine and its monohydroxy and transdiol metabolites in plasma by liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 658:1, pages 167-172.
Crossref
M. J. McLean, M. Schmutz, A. W. Wamil, H.-R. Olpe, C. Portet & K. F. Feldmann. (1994) Oxcarbazepine: Mechanisms of Action. Epilepsia 35:s3, pages S5-S9.
Crossref
P. Lloyd, G. Flesch & W. Dieterle. (1994) Clinical Pharmacology and Pharmacokinetics of Oxcarbazepine. Epilepsia 35:s3, pages S10-S13.
Crossref
PJ McKee, J Blacklaw, G Forrest, RA Gillham, SM Walker, D Connelly & MJ Brodie. (2012) A double‐blind, placebo‐controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients.. British Journal of Clinical Pharmacology 37:1, pages 27-32.
Crossref
Roger J. Porter. (2008) New Developments in the Search for Improved Antiepileptic Drugs. Psychiatry and Clinical Neurosciences 47:2, pages 145-162.
Crossref
Y. A. Hekster, D. J. P. Wijsman, E. W. Wuis, T. B. Vree & H. Meinardi. 1993. Quantitative Assessment in Epilepsy Care. Quantitative Assessment in Epilepsy Care 109 116 .
G. Kramer, B. Tettenborn, P. Klosterskov Jensen, G. P. Menge & K. D. Stoll. (1992) Oxcarbazepine Does Not Affect the Anticoagulant Activity of Warfarin. Epilepsia 33:6, pages 1145-1148.
Crossref
T. Keränen, J. Jolkkonen, P. K. Jensen, G. P. Menge & P. Andersson. (1992) Absence of interaction between oxcarbazepine and erythromycin. Acta Neurologica Scandinavica 86:2, pages 120-123.
Crossref
T. Keränen, J. Jolkkonen, P. Klosterskov-Jensen & G. P. Menge. (2009) Oxcarbazepine does not interact with cimetidine in healthy volunteers. Acta Neurologica Scandinavica 85:4, pages 239-242.
Crossref
P. H. Mogensen, L. Jórgensen, J. Boas, M. Dam, A. Vesterager, G. Flesch & P. K. Jensen. (2009) Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites. Acta Neurologica Scandinavica 85:1, pages 14-17.
Crossref
R. Hartley, M. Green, M. D. Lucock, S. Ryan & W. I. Forsythe. (1991) Solid phase extraction of oxcarbazepine and its metabolites from plasma for analysis by high performance liquid chromatography. Biomedical Chromatography 5:5, pages 212-215.
Crossref
JG Larkin, PJ McKee, G Forrest, GH Beastall, BK Park, JI Lowrie, P Lloyd & MJ Brodie. (2012) Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects.. British Journal of Clinical Pharmacology 31:1, pages 65-71.
Crossref
A. Kumps & C. Wurth. (2006) Oxcarbazepine disposition: Preliminary observations in patients. Biopharmaceutics & Drug Disposition 11:4, pages 365-370.
Crossref
A.A. Elyas, V.D. Goldberg & P.N. Patsalos. (1990) Simple and rapid micro-analytical high-performance liquid chromatographic technique for the assay of oxcarbazepine and its primary active metabolite 10-hydroxycarbazepine. Journal of Chromatography B: Biomedical Sciences and Applications 528, pages 473-479.
Crossref
S.C. Pendlebury, D.K. Moses & M.J. Eadie. (2016) Hyponatraemia during Oxcarbazepine Therapy. Human Toxicology 8:5, pages 337-344.
Crossref
. (1989) Oxcarbazepine. The Lancet 334:8656, pages 196-198.
Crossref
. (1989) Databases for Health Care Outcomes. The Lancet 334:8656, pages 195-196.
Crossref
J M Zakrzewska & P N Patsalos. (1989) Oxcarbazepine: a new drug in the management of intractable trigeminal neuralgia.. Journal of Neurology, Neurosurgery & Psychiatry 52:4, pages 472-476.
Crossref
R. G. Dickinson, W. D. Hooper, P. R. Dunstan & M. J. Eadie. (1989) First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite. European Journal of Clinical Pharmacology 37:1, pages 69-74.
Crossref
A. L. Burlingame, D. Maltby, D. H. Russell & P. T. Holland. (2002) Mass spectrometry. Analytical Chemistry 60:12, pages 294-342.
Crossref
Richard N. Armstrong. 1988. 315 324 .
Roland Heckendorn. (1987) Synthesis oftrans-10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide, a Major Metabolite of Carbamazepine. Helvetica Chimica Acta 70:7, pages 1955-1962.
Crossref

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