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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 5
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Research Article

The genetic defect of mephenytoin hydroxylation

W. Kalow Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada, M5S 1A8
Pages 379-389 | Published online: 22 Sep 2008

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Y. C. Lou. (1990) Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians. Drug Metabolism Reviews 22:5, pages 451-475.
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C. Ioannides & D. V. Parke. (1990) The Cytochrome P450 I Gene Family of Microsomal Hemoproteins and Their Role in the Metabolic Activation of Chemicals. Drug Metabolism Reviews 22:1, pages 1-85.
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K. Róna & B. Gachályi. (1989) Drug Oxidator Phenotyping by Liquid Chromatography: A Review. Journal of Liquid Chromatography 12:7, pages 1111-1130.
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Elizabeth M. J. Gillam & Paul E. B. Reilly. (1988) Phenacetin O-deethylation by human liver microsomes: Kinetics and propranolol inhibition. Xenobiotica 18:1, pages 95-104.
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U. A. Meyer, J. Gut, T. Kronbach, C. Skoda, U. T. Meier, T. Catin & P. Dayer. (1986) The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. Xenobiotica 16:5, pages 449-464.
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Articles from other publishers (16)

L.A. Stanley. 2017. Pharmacognosy. Pharmacognosy 527 545 .
Ashish Sharma, Sylvie Pilote, Pierre M. Bélanger, Marie Arsenault & Bettina A. Hamelin. (2004) A convenient five‐drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. British Journal of Clinical Pharmacology 58:3, pages 288-297.
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Dong-Ryul Sohn. (2002) Clinical implications of CYP2C19 polymorphism for tailor-made pharmacotherapy. International Congress Series 1244, pages 41-49.
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Zeruesenay Desta, Xiaojiong Zhao, Jae-Gook Shin & David A. Flockhart. (2002) Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism. Clinical Pharmacokinetics 41:12, pages 913-958.
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K. Róna & I. Szabó. (1992) Determination of mephenytoin stereoselective oxidative metabolism in urine by chiral liquid chromatography employing β-cyclodextrin as a mobile phase additive. Journal of Chromatography B: Biomedical Sciences and Applications 573:1, pages 173-177.
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CJ Doecke, ME Veronese, SM Pond, JO Miners, DJ Birkett, LN Sansom & ME McManus. (2012) Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.. British Journal of Clinical Pharmacology 31:2, pages 125-130.
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M.A. Graham, R.J. Riley & D.J. Kerr. (1991) Drug metabolism in carcinogenesis and cancer chemotherapy. Pharmacology & Therapeutics 51:2, pages 275-289.
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RJ Guttendorf, M Britto, RA Blouin, TS Foster, W John, KA Pittman & PJ Wedlund. (2012) Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.. British Journal of Clinical Pharmacology 29:4, pages 373-380.
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Grant R. Wilkinson, F. Peter Guengerich & Robert A. Branch. (1989) Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacology & Therapeutics 43:1, pages 53-76.
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W. Kalow. 1989. Clinical Pharmacology in Psychiatry. Clinical Pharmacology in Psychiatry 148 162 .
T Inaba, LF Jorge & TD Arias. (2012) Mephenytoin hydroxylation in the Cuna Amerindians of Panama.. British Journal of Clinical Pharmacology 25:1, pages 75-79.
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Bernard Testa. (1988) Substrate and product stereoselectivity in monooxygenase-mediated drug activation and inactivation. Biochemical Pharmacology 37:1, pages 85-92.
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David R. Webb, Vijendra KR. Singh, H. Hugh Fudenberg, Roger W. Russell, L. Öhman, G. Maluszynska, K.-E. MAgnusson, O. Stendahl, Peter A. Lambert, David H. P. Streeten, Gunnar H. AndersonJrJr, Vickram Ramkumar, George Pierson, Gary L. Stiles, Bernard Testa, Joachm M. Mayer, Duncan Stewart-Tull, Michael Williams, Gary L. Niel, Peter Hambleton, Stephen D. Prior, Andrew Robinson, Jed F. Fisher & Paul A. AristoffBernard Testa & Joachim M. Mayer. 1988. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 249 303 .
W. Kalow. (1987) Genetic variation in the human hepatic cytochrome P-450 system. European Journal of Clinical Pharmacology 31:6, pages 633-641.
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W. Kalow. 1987. Human Genetics. Human Genetics 507 516 .
W. Kalow. (1986) Genetics of drug transformation. Clinical Biochemistry 19:2, pages 76-82.
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