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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 5
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Research Article

The metabolism of debrisoquine in man: (1) Regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis

J. C. Ritchie Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
,
M. J. Crothers Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
,
R. R. Shah Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
,
J. R. Idle Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
&
R. L. Smith Department of Pharmacology, St Mary's Hospital Medical School, Paddington, London, W2 1PG, UK
Pages 503-509 | Published online: 22 Sep 2008

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T. Lightfoot, S. W. Ellis, J. Mahling, M. J. Ackland, F. E. Blaney, G. J. Bijloo, M. J. De Groot, N. P. E. Vermeulen, G. M. Blackburn, M. S. Lennard & G. T. Tucker. (2000) Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling. Xenobiotica 30:3, pages 219-233.
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A. G. Renwick. (1993) Data‐derived safety factors for the evaluation of food additives and environmental contaminants. Food Additives & Contaminants 10:3, pages 275-305.
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A. G. Renwick. (1991) Safety factors and establishment of acceptable daily intakes. Food Additives & Contaminants 8:2, pages 135-149.
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Articles from other publishers (4)

Vivien M. Hodges, Gael Y. Molloy & Wickramasinghe. (2001) Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow‐derived macrophages and human haemopoietic cell lines. British Journal of Haematology 108:1, pages 151-156.
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A.G. Renwick & N.R. Lazarus. (1998) Human Variability and Noncancer Risk Assessment— An Analysis of the Default Uncertainty Factor. Regulatory Toxicology and Pharmacology 27:1, pages 3-20.
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P. K. Kunicki, D. Sitkiewicz, E. Borowiecka, A. Pawlik, B. Gawrońska-Szklarz, R. Sterna, V. Bielicka-Sulzyc, H. Matsumoto & M. Radziwoń-Zaleska. (1995) Debrisoquine hydroxylation in a Polish population. European Journal of Clinical Pharmacology 47:6, pages 503-505.
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M. E. Veronese & S. McLean. (1991) Debrisoquine oxidation polymorphism in a Tasmanian population. European Journal of Clinical Pharmacology 40:5, pages 529-532.
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