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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 3
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Original Article

Application of isolated hepatocytes to studies of drug metabolism in large food animals

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Pages 345-363 | Published online: 30 Sep 2009

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Read on this site (3)

G. A. E. Van't Klooster, F. M. A. Woutersen-Van Nijnanten, B. J. Blaauboer, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1994) Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies. Xenobiotica 24:5, pages 417-428.
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G. A. E. Van ‘t Klooster, F. M. A. Woutersen-Van Nijnanten, W. R. Klein, B. J. Blaauboer, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1992) Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies. Xenobiotica 22:5, pages 523-534.
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L. A. P. Hoogenboom, F. J. H. Pastoor, W. E. Clous, S. E. Hesse & H. A. Kuiper. (1989) The use of porcine hepatocytes for biotransformation studies of veterinary drugs. Xenobiotica 19:11, pages 1207-1219.
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Articles from other publishers (17)

Justyna Barć, Jadwiga Flaga, Anna Kozubek & Zygmunt Maciej Kowalski. (2023) Short Culture of Bovine Hepatocytes Biopsied from Dairy Cows as a Model for Toxicological Studies—CYP 1A1 Activity Response to Zearalenone Treatment. International Journal of Molecular Sciences 24:15, pages 12344.
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Alexander Gleich, Bastian Kaiser, Walther Honscha, Herbert Fuhrmann & Axel Schoeniger. (2019) Evaluation of the hepatocyte-derived cell line BFH12 as an in vitro model for bovine biotransformation. Cytotechnology 71:1, pages 231-244.
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Ludovic Peyre, Georges de Sousa, Sylvie Barcellini-Couget, Anne-Pascale Luzy, Nathalie Zucchini-Pascal & Roger Rahmani. (2015) High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical’s bio-activation with regards hepatotoxicity. Toxicology in Vitro 29:7, pages 1916-1931.
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Santanu Panda, Sonu Bisht, Dhruba Malakar, Ashok K. Mohanty & Jai K. Kaushik. (2015) In Vitro Culture of Functionally Active Buffalo Hepatocytes Isolated by Using a Simplified Manual Perfusion Method. PLOS ONE 10:3, pages e0118841.
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Thomas Baker, Marnie Higgins, Mark Carfagna & Timothy Ryan. 2003. An Introduction to Toxicogenomics. An Introduction to Toxicogenomics.
J. Dupuy, G. Larrieu, J. F. Sutra, C. Eeckhoutte & M. Alvinerie. (2001) Influence of verapamil on the efflux and metabolism of 14 C moxidectin in cultured rat hepatocytes . Journal of Veterinary Pharmacology and Therapeutics 24:3, pages 171-177.
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Michael Sinz. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 401 424 .
Sean Ekins, Jukka Maenpää & Steven Wrighton. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 363 399 .
Myriam Coulet, Claudine Eeckhoutte, Gilberte Larrieu, Jean-François Sutra, Laurentius A. P. Hoogenboom, Margot B. M. Huveneers-Oorsprong, Harry A. Kuiper, José V. Castell, Michel Alvinerie & Pierre Galtier. (1998) Comparative Metabolism of Thiabendazole in Cultured Hepatocytes from Rats, Rabbits, Calves, Pigs, and Sheep, Including the Formation of Protein-Bound Residues. Journal of Agricultural and Food Chemistry 46:2, pages 742-748.
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L.A.P. Hoogenboom & H.A. Kuiper. (1997) The use of in vitro models for assessing the presence and safety of residues of xenobiotics in food. Trends in Food Science & Technology 8:5, pages 157-166.
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Elisabeth G. Jensen, Rune Thauland & Nils E. Soli. (2020) Measurement of Xenobiotic Metabolising Enzyme Activities in Primary Monolayer Cultures of Immature Rainbow Trout Hepatocytes at Two Acclimatisation Temperatures. Alternatives to Laboratory Animals 24:5, pages 727-740.
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C. Montesissa, P. Anfossi, G. Van't Klooster & M. Mengelers. (1996) The use of cultured hepatocytes from goats and cattle to investigate xenobiotic oxidative metabolism. Veterinary Research Communications 20:5, pages 449-460.
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Anje A te Velde, Nita C.J.J. Ladiges, Leonard M. Flendrig & Robert A.F.M. Chamuleau. (1995) Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver. Journal of Hepatology 23:2, pages 184-192.
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G. A. E. VAN T KLOOSTER, B.J. BLAAUBOER, J‐ NOORDHOEK & A. S.J. P. A. M. VAN MIERT. (2008) Sulfadimidine metabolism in vitro: II. comparative studies in cultured rat, goat, sheep and cattle hepatocytes. Journal of Veterinary Pharmacology and Therapeutics 16:4, pages 454-461.
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. 1991. Isolated Hepatocytes Preparation, Properties and Applications. Isolated Hepatocytes Preparation, Properties and Applications 409 439 .
L.A.P. Hoogenboom, M.B.M. Oorsprong, T. van Vliet & H.A. Kuiper. (1991) The use of pig hepatocytes for cytotoxicity studies of veterinary drugs: A comparative study with furazolidone and other nitrofurans. Toxicology in Vitro 5:1, pages 31-38.
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Laurentius A.P. Hoogenboom, Marcel C.J. Berghmans & Wim A. Traag. (1989) Biotransformation of β-nortestosterone by cultured porcine hepatocytes. Journal of Chromatography B: Biomedical Sciences and Applications 489:1, pages 105-109.
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