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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 9
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Research Article

Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes

M. Ŝktefek Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta, 842 16, Bratislava, Czechoslovakia
,
L. Beneŝk Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta, 842 16, Bratislava, Czechoslovakia
,
M. Jergelová Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta, 842 16, Bratislava, Czechoslovakia
,
V. ŜkĉKasnár Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta, 842 16, Bratislava, Czechoslovakia
,
L. Turi-nagy Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Dúbravská cesta, 842 16, Bratislava, Czechoslovakia
&
P. Koĉkiŝk Institute of Chemistry, Centre of Chemical Research, Slovak Academy of Sciences, Dúbravská cesta, 842 38, Bratislava, Czechoslovakia
Pages 1067-1073 | Received 28 Jul 1986, Published online: 22 Sep 2008

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M. Stefek. (1993) I n vitvo studies on the interaction of the pyridoindole antioxidant stobadine with rat liver microsomal P450. Xenobiotica 23:9, pages 983-993.
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M. Štefek & L. Beneš. (1989) Hydrogen Peroxide-Dependent Liver Microsomal N-Demethylation and N-Oxygenation of Stobadine, a γ-Carboline Antiarrhythmic and Cardioprotective Agent. Xenobiotica 19:6, pages 627-634.
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M. Ŝtefek, L. Beneŝ & V. Zelník. (1989) N-oxygenation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent: The role of flavin-containing monooxygenase. Xenobiotica 19:2, pages 143-150.
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Articles from other publishers (11)

R. S. Alekseyev, A. V. Kurkin & M. A. Yurovskaya. (2011) γ-Carbolines and their hydrogenated derivatives 3.* Hydrogenated derivatives of γ-carbolines: chemical and biological poperties (Review). Chemistry of Heterocyclic Compounds 46:10, pages 1169-1198.
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L. ??olt�s, ??. Bezek, E. Ujh�zy & V. Bauer. (2000) Extraction and chromatographic separation methods in pharmacokinetic studies of Stobadine�?an indole-related antioxidant and free-radical scavenger. Biomedical Chromatography 14:3, pages 188-201.
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Š. Bezek, L. Šortés, V. Ščasnár, K. Bauerová, Z. Kállay, M. Ďurišová, D. Mihalová, P. Bohov, V. Faberová, M. Kukan, T. Trnovec & V. Koprda. (1999) Pharmacokinetic study of stobadine. Life Sciences 65:18-19, pages 2003-2005.
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K. Bauerová. (1999) Overview of stobadine bioanalysis: evaluation and application in pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 24:3, pages 237-242.
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L' Horáková & S Štolc. (1998) Antioxidant and Pharmacodynamic Effects of Pyridoindole Stobadine. General Pharmacology: The Vascular System 30:5, pages 627-638.
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E Orviský, L Šoltés & Mária Stančı́ková. (1997) High-molecular-weight hyaluronan—a valuable tool in testing the antioxidative activity of amphiphilic drugs stobadine and vinpocetine. Journal of Pharmaceutical and Biomedical Analysis 16:3, pages 419-424.
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M. Stefek, I. Drozdikova & K. Vajdova. (1996) The pyridoindole antioxidant stobadine inhibited glycation-induced absorbance and fluorescence changes in albumin. Acta Diabetologica 33:1, pages 35-40.
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Milan Stefek & Zuzana Trnkova. (2009) Inhibition of Alloxan‐Induced Hyperglycaemia in Mice by the Pyridoindole Stobadine. Pharmacology & Toxicology 77:5, pages 320-322.
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Lubica Horáková, Helmut Sies & Steen Steenken. 1994. Oxygen Radicals in Biological Systems Part D. Oxygen Radicals in Biological Systems Part D 572 580 .
Mark R. Hadley, Harriet G. Oldham, Lyaquatali A. Damani & Andrew J. Hutt. (2004) Asymmetric metabolic N ‐oxidation of N ‐ethyl‐ N ‐methylaniline by purified flavin‐containing monooxygenase . Chirality 6:2, pages 98-104.
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V. Ščasnár, Š. Bezek & T. Trnovec. (1989) Fluorimetric assay of stobadine in serum of dogs. Journal of Pharmaceutical and Biomedical Analysis 7:10, pages 1207-1212.
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