Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 10
36
Views
19
CrossRef citations to date
0
Altmetric
Original Article

Metabolism and pharmacokinetics of cinobufagin

, , , , &
Pages 1195-1202 | Received 29 Sep 1986, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Xiangjiu He, Hui Hu, Yixuan Wu & Xiaobin Zeng. (2012) Urinary metabolites of cinobufagin in rats and their antiproliferative activities. Natural Product Research 26:6, pages 489-499.
Read now
J. Ning, T.-H. Wu, Y. Tian, C.-Y. Wang, G. Tian, B.-J. Zhang, K.-X. Liu & X.-C. Ma. (2010) Identification of cinobufagin metabolites in the bile of rats. Xenobiotica 40:1, pages 48-54.
Read now
Lisha Zhang, Kimiko Aoki, Takemi Yoshida & Yukio Kuroiwa. (1990) Simultaneous Determinations of Cinobufagin and Its Metabolites by Reverse-Phase High Performance Liquid Chromatography in Rat Serum and Urine. Journal of Liquid Chromatography 13:17, pages 3515-3530.
Read now

Articles from other publishers (16)

Jieping Zhao, Xiu Chen, Hengbin Zhang, Xiaoyan Liu, Yiwen Ma, Jianbiao Yao, Huidi Jiang & Hui Zhou. (2024) Quantification of nine bufadienolides of Shexiang Tongxin Dropping Pills in rat plasma and tissues using UPLC-MS/MS and its application to healthy and ischemia-reperfusion rats pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 238, pages 115852.
Crossref
Qingmei Ye, Xin Zhou, Fangxuan Han & Caijuan Zheng. (2023) Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions. Frontiers in Chemistry 11.
Crossref
Ming Li, Yanhong Qin, Zhe Li, Jinshuai Lan, Tong Zhang & Yue Ding. (2022) Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS. Frontiers in Pharmacology 13.
Crossref
Kunyan He, Guang-Xing Wang, Li-Nan Zhao, Xiao-Fang Cui, Xian-Bin Su, Yi Shi, Tian-Pei Xie, Shang-Wei Hou & Ze-Guang Han. (2021) Cinobufagin Is a Selective Anti-Cancer Agent against Tumors with EGFR Amplification and PTEN Deletion. Frontiers in Pharmacology 12.
Crossref
Shu‐Shong Hsu, Yung‐Shang Lin & Wei‐Zhe Liang. (2021) Investigation of cytotoxic effect of the bufanolide steroid compound cinobufagin and its related underlying mechanism in brain cell models. Journal of Biochemical and Molecular Toxicology 35:10.
Crossref
Wenlong Wei, Haojv Li, Zhenwei Li, Hua Qu, Juan Da, Xu Jin, Yingying Wang, Wanying Wu & De-an Guo. (2019) Simultaneous determination of cinobufagin and its five metabolites in rat plasma by LC-MS/MS for characterization of metabolic profiles and pharmacokinetic study. Analytical Methods 11:42, pages 5464-5471.
Crossref
Yujie Feng, Chao Wang, Xiangge Tian, Xiaokui Huo, Lei Feng, Chengpeng Sun, Guangbo Ge, Ling Yang, Jing Ning & Xiaochi Ma. (2017) In vitro phase I metabolism of gamabufotalin and arenobufagin: Reveal the effect of substituent group on metabolic stability. Fitoterapia 121, pages 38-45.
Crossref
Stephanie JohnnidesTiffany GreenPaul Eubig. (2016) Toad Intoxication in the Dog by Rhinella marina: The Clinical Syndrome and Current Treatment Recommendations. Journal of the American Animal Hospital Association 52:4, pages 205-211.
Crossref
Jing Ning, Yonglei Cui, Chao Wang, Peipei Dong, Guangbo Ge, Xiangge Tian, Jie Hou, Xiaokui Huo, Baojing Zhang, Tonghui Ma & Xiaochi Ma. (2016) Characterization of regio- and stereo-selective sulfation of bufadienolides: exploring the mechanism and providing insight into the structure–sulfation relationship by experimentation and molecular docking analysis. RSC Advances 6:7, pages 5774-5783.
Crossref
Xiao-Chi Ma, Jing Ning, Guang-Bo Ge, Si-Cheng Liang, Xiu-Li Wang, Bao-Jing Zhang, Shan-Shan Huang, Jing-Kui Li & Ling Yang. (2011) Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human. Drug Metabolism and Disposition 39:4, pages 675-682.
Crossref
Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 996 1007 .
Yan Liang, Ai-hua Liu, Song Qin, Jiang-hao Sun, Min Yang, Ping Li & De-an Guo. (2008) Simultaneous determination and pharmacokinetics of five bufadienolides in rat plasma after oral administration of Chansu extract by SPE-HPLC method. Journal of Pharmaceutical and Biomedical Analysis 46:3, pages 442-448.
Crossref
Kazutake Shimada, Yoshimichi Miyashiro & Tadashi Nishio. (2006) Characterization ofin vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography–mass spectrometry. Biomedical Chromatography 20:12, pages 1321-1327.
Crossref
Xiangjiu He, Jinshan Tang, Aimin Qiao, Guanghui Wang, Miaomiao Jiang, Rui Hai Liu & Xinsheng Yao. (2006) Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger. Steroids 71:5, pages 392-402.
Crossref
Min Ye, Lili Ning, Jixun Zhan, Hongzhu Guo & Dean Guo. (2003) Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum. Journal of Molecular Catalysis B: Enzymatic 22:1-2, pages 89-95.
Crossref
Shin-ichi Morishita, Masamichi Shoji, Yasuhiro Oguni, Chihiro Ito, Katsuhiko Noguchi & Matao Sakanashi. (1991) Congestive Heart Failure Model in Rabbits: Effects of Digoxin and a Drug Containing Toad Venom. Japanese Journal of Pharmacology 56:4, pages 427-432.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.