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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 2
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Original Article

Metabolism of amlodipine in the rat and the dog: A species difference

A. P. Beresford Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent, UK
,
P. V. Macrae Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent, UK
&
D. A. Stopher Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent, UK
Pages 169-182 | Received 13 Feb 1987, Published online: 30 Sep 2009

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Dong-Jin Jang, Taeyong Sim & Euichaul Oh. (2013) Formulation and optimization of spray-dried amlodipine solid dispersion for enhanced oral absorption. Drug Development and Industrial Pharmacy 39:7, pages 1133-1141.
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S. G. Jezequel, S. Uden & P. Wastall. (1996) Modipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man. Xenobiotica 26:9, pages 963-975.
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H. Nakabeppu, M. Asada, T. Oda, Y. Shinozaki & T. Yajima. (1996) Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica 26:2, pages 229-239.
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T. Teramura, T. Tokunaga, H. Matsumoto, T. Watanabe & S. Higuchi. (1996) Metabolism of barnidipine hydrochloride, a potent calcium antagonist, in rat and dog. Xenobiotica 26:2, pages 177-187.
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M. Strolin Benedetti & P. Dostert. (1994) Contribution of Amine Oxidases to the Metabolism of Xenobiotics. Drug Metabolism Reviews 26:3, pages 507-535.
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D. K. Walker, M. J. Humphrey & D. A. Smith. (1994) Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine. Xenobiotica 24:3, pages 243-250.
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P. Grossi, M. Pellegatti, G. Vigelli, J. Ayrton, B. A. Duncan & J. Maltas. (1992) Lacidipine metabolism in rat and dog: identification and synthesis of main metabolites. Xenobiotica 22:8, pages 899-916.
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F. Takayama, Y. Iwasawa, K. Saito, K. Shiratori & M. Ohtawa. (1989) Metabolism of a new dihydropyridine calcium antagonist in rats and dogs. Xenobiotica 19:12, pages 1407-1420.
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Articles from other publishers (22)

Hui-Qing Chen, Jin-Yu Gong, Kai Xing, Mou-Ze Liu, Huan Ren & Jian-Quan Luo. (2022) Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment. Frontiers in Medicine 8.
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Christine Quentin, Rūta Gerasimaitė, Alexandra Freidzon, Levon S. Atabekyan, Gražvydas Lukinavičius, Vladimir N. Belov & Gyuzel Y. Mitronova. (2021) Direct Visualization of Amlodipine Intervention into Living Cells by Means of Fluorescence Microscopy. Molecules 26:10, pages 2997.
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O. I. Avdeeva, M. N. Makarova, I. E. Makarenko, P. V. Burenkov, M. G. Shubina & V. A. Kashkin. (2016) TTOXICOLOGICAL EVALUATION OF COMBINATION OF AMLODIPINE CALCIUM CHANNELS BLOCKER WITH ANGIOTENSIN RECEPTOR BLOCKERS. Toxicological Review:1, pages 13-17.
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Hye Hyun Yoo, In Sook Kim, Dae-Hyeong Yoo & Dong-Hyun Kim. (2016) Effects of orally administered antibiotics on the bioavailability of amlodipine. Journal of Hypertension 34:1, pages 156-162.
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Yanlin Zhu, Fen Wang, Quan Li, Mingshe Zhu, Alicia Du, Wei Tang & Weiqing Chen. (2014) Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation. Drug Metabolism and Disposition 42:2, pages 245-249.
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Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 6 .
. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 81 102 .
Gennady Ananchenko, Jasmina Novakovic & Johnathan Lewis. 2012. 31 77 .
M. Largeron. (2011) Amine oxidases of the quinoproteins family: Their implication in the metabolic oxidation of xenobiotics. Annales Pharmaceutiques Françaises 69:1, pages 53-61.
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J.D. Thomason, T.L. Fallaw, K.P. Carmichael, M.A. Radlinsky & C.A. Calvert. (2009) Gingival Hyperplasia Associated with the Administration of Amlodipine to Dogs with Degenerative Valvular Disease (2004-2008). Journal of Veterinary Internal Medicine 23:1, pages 39-42.
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Bohumila Suchanova, Risto Kostiainen & Raimo A. Ketola. (2008) Characterization of the in vitro metabolic profile of amlodipine in rat using liquid chromatography–mass spectrometry. European Journal of Pharmaceutical Sciences 33:1, pages 91-99.
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Margherita Strolin Benedetti, Keith F. Tipton & Rhys Whomsley. (2007) Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?. Fundamental & Clinical Pharmacology 21:5, pages 467-480.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Bohumila Suchanova, Ludek Sispera & Vladimir Wsol. (2006) Liquid chromatography–tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes. Analytica Chimica Acta 573-574, pages 273-283.
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. 2005. Drug Metabolism. Drug Metabolism 41 128 .
Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Margherita Strolin Benedetti. (2001) Biotransformation of xenobiotics by amine oxidases. Fundamental & Clinical Pharmacology 15:2, pages 75-84.
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Hans H Maurer. (1999) Systematic toxicological analysis procedures for acidic drugs and/or metabolites relevant to clinical and forensic toxicology and/or doping control. Journal of Chromatography B: Biomedical Sciences and Applications 733:1-2, pages 3-25.
Crossref
Patti S. Snyder. (1998) Amlodipine: A Randomized, Blinded Clinical Trial in 9 Cats with Systemic Hypertension. Journal of Veterinary Internal Medicine 12:3, pages 157-162.
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M. Strolin Benedetti & K. F. Tipton. 1998. MAO — The Mother of all Amine Oxidases. MAO — The Mother of all Amine Oxidases 149 171 .
Takao Saruta, Masao Ishii, Keishi Abe & Isamo Iimura. (2009) Efficacy and safety of amlodipine in hypertensive patients with renal dysfunction. Clinical Cardiology 17:6, pages 317-324.
Crossref
R. Wyss & W. Philipp. (1990) Determination of the monoamine oxidase B inhibitor Ro 19-6327 in plasma by high-performance liquid chromatography using precolumn derivatization with fluorescamine and fluorescence detection. Journal of Chromatography A 507, pages 187-198.
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