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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 2
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Original Article

Metabolism and kinetics of amlodipine in man

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Pages 245-254 | Received 27 May 1987, Published online: 30 Sep 2009

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Shinji Yasuno, Akira Fujimoto, Yasuaki Nakagawa, Koichiro Kuwahara & Kenji Ueshima. (2012) Fixed-dose combination therapy of candesartan cilexetil and amlodipine besilate for the treatment of hypertension in Japan. Expert Review of Cardiovascular Therapy 10:5, pages 577-583.
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M. Strolin Benedetti & P. Dostert. (1994) Contribution of Amine Oxidases to the Metabolism of Xenobiotics. Drug Metabolism Reviews 26:3, pages 507-535.
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Seth B. Forman & Katherine Roy. 2021. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 358 365.e3 .
Aliyeh Dehdashti & Ali Babaei. (2020) Highly Sensitive Electrochemical Sensor Based on Pt Doped NiO Nanoparticles/MWCNTs Nanocomposite Modified Electrode for Simultaneous Sensing of Piroxicam and Amlodipine. Electroanalysis 32:5, pages 1017-1024.
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Sai Prasad Desikan, Phillip Sobash, Andrew Fisher & Raman Desikan. (2020) Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer. Journal of Investigative Medicine High Impact Case Reports 8, pages 232470962094727.
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Rabia Johnson, Phiwayinkosi Dludla, Sihle Mabhida, Mongi Benjeddou, Johan Louw & Faghri February. (2019) Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review. Heart Failure Reviews 24:3, pages 343-357.
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P. Markova & R. Girchev. (2019) The role of l-type calcium channels in the mediation of fast oscillation of arterial blood pressure and renal blood flow in rats. Trakia Journal of Sciences 17:3, pages 253-258.
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Dwaipayan Mukherjee, Jiuhong Zha, Rajeev M. Menon & Mohamad Shebley. (2018) Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic/pharmacodynamic model. Journal of Pharmacokinetics and Pharmacodynamics 45:3, pages 443-456.
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Timothy T. X. Ong, Ewan W. Blanch & Oliver A. H. Jones. (2018) Predicted environmental concentration and fate of the top 10 most dispensed Australian prescription pharmaceuticals. Environmental Science and Pollution Research 25:11, pages 10966-10976.
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Kristyna Krasulova, Ondrej Holas & Pavel Anzenbacher. (2017) Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity. Molecules 22:11, pages 1879.
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Noemi Santos-Cab, Lina Marcela Barranco-G, Jose Carlos Aguilar-Ca, Miriam del Carmen Carrasco-P & Francisco Javier Flores-Mur. (2016) Evaluation of the Possible Pharmacokinetic Interaction Between Amlodipine, Losartan and Hydrochlorothiazide in Mexican Healthy Volunteers. International Journal of Pharmacology 12:2, pages 101-107.
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Hye Hyun Yoo, In Sook Kim, Dae-Hyeong Yoo & Dong-Hyun Kim. (2016) Effects of orally administered antibiotics on the bioavailability of amlodipine. Journal of Hypertension 34:1, pages 156-162.
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Takafumi Naito, Naoko Kubono, Takuya Ishida, Shuhei Deguchi, Masahisa Sugihara, Hiroaki Itoh, Naohiro Kanayama & Junichi Kawakami. (2015) CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine. Drug Metabolism and Pharmacokinetics 30:6, pages 419-424.
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Matt Shirley & Paul L. McCormack. (2015) Perindopril/Amlodipine (Prestalia®): A Review in Hypertension. American Journal of Cardiovascular Drugs 15:5, pages 363-370.
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Hongbin Yu, Suresh K. Balani, Weichao Chen, Donghui Cui, Ling He, W. Griffith Humphreys, Jialin Mao, W. George Lai, Anthony J. Lee, Heng-Keang Lim, Christopher MacLauchlin, Chandra Prakash, Sekhar Surapaneni, Susanna Tse, Alana Upthagrove, Robert L. Walsky, Bo Wen & Zhaopie Zeng. (2015) Contribution of Metabolites to P450 Inhibition–Based Drug–Drug Interactions: Scholarship from the Drug Metabolism Leadership Group of the Innovation and Quality Consortium Metabolite Group. Drug Metabolism and Disposition 43:4, pages 620-630.
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Parviz Norouzi, Vinod Kumar Gupta, Bagher Larijani, Solmaz Rasoolipour, Farnoush Faridbod & Mohammad R. Ganjali. (2015) Coulometric differential FFT admittance voltammetry determination of Amlodipine in pharmaceutical formulation by nano-composite electrode. Talanta 131, pages 577-584.
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T. Firouzyar, A. R. Jalilian, M. Shafiee-Ardestani, M. R. Aboudzadeh, Y. Fazaeli, F. Bolourinovin, M. Mirzaii & A. Khalaj. (2014) Development of an 111In-labeled dihydropyridine complex for L-type calcium channel imaging. Journal of Radioanalytical and Nuclear Chemistry.
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Yanlin Zhu, Fen Wang, Quan Li, Mingshe Zhu, Alicia Du, Wei Tang & Weiqing Chen. (2014) Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation. Drug Metabolism and Disposition 42:2, pages 245-249.
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Najma Sultana, M. Saeed Arayne & Saeeda Nadir Ali. (2013) Liquid chromatographic method for the simultaneous determination of captopril, piroxicam, and amlodipine in bulk drug, pharmaceutical formulation, and human serum by programming the detector. Journal of Separation Science 36:19, pages 3176-3183.
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Kishore Kumar Hotha, Swapan Roychowdhury, Ramesh Mullangi & L. K. Ravindranath. (2013) Rapid quantification of amlodipine enantiomers in human plasma by LC‐MS/MS: application to a clinical pharmacokinetic study. Biomedical Chromatography 27:9, pages 1192-1199.
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Raja Reddy Kallem, Ramesh Mullangi, Kishore Kumar Hotha, LK Ravindranath, YN Spoorthy & JVLN Seshagirirao. (2013) Simultaneous estimation of amlodipine and atenolol in human plasma: a sensitive LC–MS/MS method validation and its application to a clinical PK study. Bioanalysis 5:7, pages 827-837.
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György T. Balogh, Judit Müller & Árpád Könczöl. (2013) pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery. European Journal of Pharmaceutical Sciences 49:1, pages 81-89.
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Mahmoud Yacoub, Ahmad Abu awwad, Mahmoud Alawi & Tawfiq Arafat. (2013) Simultaneous determination of amlodipine and atorvastatin with its metabolites; ortho and para hydroxy atorvastatin; in human plasma by LC–MS/MS. Journal of Chromatography B 917-918, pages 36-47.
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S Bohlooli, M Mahmoudian, G G Skellern, M H Grant & J N A Tettey. (2004) Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes. Journal of Pharmacy and Pharmacology 56:11, pages 1469-1475.
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Bohumila Suchanova, Risto Kostiainen & Raimo A. Ketola. (2008) Characterization of the in vitro metabolic profile of amlodipine in rat using liquid chromatography–mass spectrometry. European Journal of Pharmaceutical Sciences 33:1, pages 91-99.
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Margherita Strolin Benedetti, Keith F. Tipton & Rhys Whomsley. (2007) Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?. Fundamental & Clinical Pharmacology 21:5, pages 467-480.
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Kwang-Seok Oh, Maeng-Sup Kim & Byung-Ho Lee. (2007) Antihypertensive Effects of Enantiomers of Amlodipine Camsylate, a Novel Salt of Amlodipine. Biomolecules and Therapeutics 15:1, pages 40-45.
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