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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 3
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Original Article

Fungal transformations of antihistamines: Metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives

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Pages 301-312 | Received 06 Apr 1987, Accepted 02 Oct 1987, Published online: 30 Sep 2009

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D. W. Kelly, C. L. Holder, W. A. Korfmacher, T. A. Getek, J. O. Lay, D. A. Casciano, J. G. Shaddock, H. M. Duhart & W. Slikker. (1992) Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. Xenobiotica 22:12, pages 1367-1381.
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Articles from other publishers (18)

Jia Zeng, David Gage & Jixun Zhan. (2012) Production of a new pyridine N-oxide by bioconversion with Cunninghamella echinulata var. elegans. Journal of Bioscience and Bioengineering 114:5, pages 497-499.
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Sepuri Asha & Maravajhala Vidyavathi. (2009) Cunninghamella – A microbial model for drug metabolism studies – A review. Biotechnology Advances 27:1, pages 16-29.
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Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams & B. Kevin Park. (2008) Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. Journal of Pharmacology and Experimental Therapeutics 326:2, pages 657-671.
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Igor A. Parshikov, James P. Freeman, Jackson O. LayJr.Jr., Richard D. Beger, Anna J. Williams & John B. Sutherland. (2000) Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus . Applied and Environmental Microbiology 66:6, pages 2664-2667.
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Rong-Fu Wang, Ashraf A. Khan, Wei-Wen Cao & Carl E. Cerniglia. (2000) Cloning, sequencing, and expression of the gene encoding enolase from Cunninghamella elegans. Mycological Research 104:2, pages 175-179.
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R. Azerad. 1999. Biotransformations. Biotransformations 169 218 .
Rong-Fu Wang, Ashraf A Khan, Wei-Wen Cao & Carl E Cerniglia. (1998) Identification and sequencing of a cDNA encoding 6-phosphogluconate dehydrogenase from a fungus, Cunninghamella elegans and expression of the gene in Escherichia coli . FEMS Microbiology Letters 169:2, pages 397-402.
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Xing-Fang Li, Chung-Sheng Liu, Pieter Roos, Eugene B. Hansen, Carl E. Cerniglia & Norman J. Dovichi. (1998) Nonaqueous capillary electrophoretic separation and thermo-optical absorbance detection of five tricyclic antidepressants and metabolism of amitriptyline byCunninghamella elegans. Electrophoresis 19:18, pages 3178-3182.
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Donglu Zhang, Frederick E. Evans, James P. Freeman, Yifan Yang, Joanna Deck & Carl E. Cerniglia. (1996) Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans. Chemico-Biological Interactions 102:2, pages 79-92.
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D ZhangE B HansenJrJrJ DeckT M HeinzeJ B SutherlandC E Cerniglia. (1996) Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Applied and Environmental Microbiology 62:9, pages 3477-3479.
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Donglu Zhang, Yifan Yang, Julian E.A Leakey & Carl E Cerniglia. (1996) Phase I and phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics . FEMS Microbiology Letters 138:2-3, pages 221-226.
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C.L. Holder, W. SlikkerJrJr & H.C. ThompsonJrJr. (1994) Comparison of the metabolism and elimination of pyrilamine maleate in the rat, mouse and female rhesus monkey. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 107:1, pages 159-164.
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Herbert L. Holland. 1992. Biotechnology of Filamentous Fungi. Biotechnology of Filamentous Fungi 157 187 .
David A. Griffiths, David J. Best & Serge G. Jezequel. (1991) The screening of selected microorganisms for use as models of mammalian drug metabolism. Applied Microbiology and Biotechnology 35:3, pages 373-381.
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Yiu W.J. Wong & Patrick J. Davis. (1991) Microbial Models of Mammalian Metabolism: Production of 3'-Hydroxywarfarin, a New Metabolite of Warfarin Using Cunninghamella elegans. Journal of Pharmaceutical Sciences 80:4, pages 305-308.
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Hans H. Maurer. (1990) Chromatography of histamine H1- and H2-receptor blockers in biosamples. Journal of Chromatography B: Biomedical Sciences and Applications 531, pages 369-405.
Crossref
W.A. Korfmacher, T.A. Getek, E.B. HansenJr.Jr. & C.E. Cerniglia. (1990) Direct analysis of microbial extracts containing metabolites of ethylenediamine-type antihistamines via high-performance liquid chromatography-thermospray mass spectrometry. Analytical Biochemistry 185:1, pages 136-142.
Crossref
Herbert L. Holland, Morgan Conn, P.Chinna Chenchaiah & Frances M. Brown. (1988) Removal of O-and N-benzyl groups by fungal biotransformation. Tetrahedron Letters 29:49, pages 6393-6394.
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