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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
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Original Article

Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage

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Pages 397-405 | Received 29 Apr 1987, Accepted 13 Nov 1987, Published online: 30 Sep 2009

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Abhishek Dubey, Dae Won Park, Jung Eun Kwon, Yong Joon Jeong, Taegeun Kim, Inhye Kim, Se Chan Kang & Ki-Whan Chi. (2015) Investigation of the biological and anti-cancer properties of ellagic acid-encapsulated nano-sized metalla-cages. International Journal of Nanomedicine 10:sup1, pages 227-240.
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Manika Varshney, Vinod Vijayan & Ghansham P. Meshram. (2015) Chemopreventive effects of ellagic acid against genotoxicity induced by benzo(a)pyrene. Toxicological & Environmental Chemistry 97:6, pages 786-798.
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Essi Päivärinta, Anne-Maria Pajari, Riitta Törrönen & Marja Mutanen. (2006) Ellagic Acid and Natural Sources of Ellagitannins as Possible Chemopreventive Agents Against Intestinal Tumorigenesis in the Min Mouse. Nutrition and Cancer 54:1, pages 79-83.
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SANDRAM. HANNUM. (2004) Potential Impact of Strawberries on Human Health: A Review of the Science. Critical Reviews in Food Science and Nutrition 44:1, pages 1-17.
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Mohamed Boukharta, Guylaine Jalbert & Andre Castonguay. (1992) Biodistribution of ellagic acid and dose‐related inhibition of lung tumorigenesis in A/J mice. Nutrition and Cancer 18:2, pages 181-189.
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Articles from other publishers (37)

Giada Benedetti, Federica Zabini, Luca Tagliavento, Francesco Meneguzzo, Vincenzo Calderone & Lara Testai. (2023) An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate. Antioxidants 12:7, pages 1351.
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Maryam Nakhjavani & Sarah Shigdar. (2022) Natural Blockers of PD-1/PD-L1 Interaction for the Immunotherapy of Triple-Negative Breast Cancer-Brain Metastasis. Cancers 14:24, pages 6258.
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Jong Hyun Moon, Tae Yoon Kim, Uk LeeJong Min Kim, Hyo Lim Lee, Min Ji Kim, Hye Rin Jeong, Min Ji Go, Seung Gyum Joo & Ho Jin Heo. (2022) Protective Effect of Ethyl Acetate Fraction from Domestic Walnut ( Juglans regia ) against PM 2.5 -induced Inflammation and Apoptosis . Journal of the Korean Society of Food Science and Nutrition 51:9, pages 997-1006.
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Mateusz Pieróg, Katarzyna Socała, Elżbieta Wyska, Ewa Poleszak & Piotr Wlaź. (2021) Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice. Molecules 26:16, pages 4841.
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Chengshi Ding, Haidan Bi, Deya Wang, Meiling Kang, Zhongjing Tian, Yingxia Zhang, Hongkai Wang, Tianshun Zhu & Jing Ma. (2019) Preparation of Chitosan/Alginate-ellagic Acid Sustained-release Microspheres and their Inhibition of Preadipocyte Adipogenic Differentiation. Current Pharmaceutical Biotechnology 20:14, pages 1213-1222.
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Hongkai Wang, Yingxia Zhang, Zhongjing Tian, Jing Ma, Meiling Kang, Chengshi Ding & Dongfeng Ming. (2017) Preparation of β-CD-Ellagic Acid Microspheres and Their Effects on HepG2 Cell Proliferation. Molecules 22:12, pages 2175.
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Yu-qing SUN, Xin TAO, Xiao-ming MEN, Zi-wei XU & Tian WANG. (2017) In vitro and in vivo antioxidant activities of three major polyphenolic compounds in pomegranate peel: Ellagic acid, punicalin, and punicalagin. Journal of Integrative Agriculture 16:8, pages 1808-1818.
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Mohammad Reza Sepand, Mohammad Hossein Ghahremani, Kamal Razavi-Azarkhiavi, Mehdi Aghsami, Jalil Rajabi, Hedieh Keshavarz-Bahaghighat & Maliheh Soodi. (2016) Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity. Journal of Pharmacy and Pharmacology 68:9, pages 1222-1232.
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Sanmuga Priya Ekambaram, Senthamil Selvan Perumal & Ajay Balakrishnan. (2016) Scope of Hydrolysable Tannins as Possible Antimicrobial Agent. Phytotherapy Research 30:7, pages 1035-1045.
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Rakesh P. Nankar & Mukesh Doble. (2015) Ellagic acid potentiates insulin sensitising activity of pioglitazone in L6 myotubes. Journal of Functional Foods 15, pages 1-10.
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Ashwell R. Ndhlala, Bhekumthetho Ncube & Johannes van Staden. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 3987 4002 .
Chandrashekaran Girish, Vishnu Raj, Jayasree Arya & Sadasivam Balakrishnan. (2013) Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice. European Journal of Pharmacology 710:1-3, pages 49-58.
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Daniely Cornélio Favarin, Maxelle Martins Teixeira, Ednéia Lemos de Andrade, Claudiney de Freitas Alves, Javier Emilio Lazo Chica, Carlos Artério Sorgi, Lúcia Helena Faccioli & Alexandre Paula Rogerio. (2013) Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation 2013, pages 1-13.
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Andrea Berni, Maria Rosaria Grossi, Gaetano Pepe, Silvia Filippi, Sowndarya Muthukumar, Cristiano Papeschi, Adayapalam T. Natarajan & Fabrizio Palitti. (2012) Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:1, pages 60-65.
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Lydia Kaume, Luke R. Howard & Latha Devareddy. (2011) The Blackberry Fruit: A Review on Its Composition and Chemistry, Metabolism and Bioavailability, and Health Benefits. Journal of Agricultural and Food Chemistry 60:23, pages 5716-5727.
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Srivani Ravoori, Manicka V. Vadhanam, Farrukh Aqil & Ramesh C. Gupta. (2012) Inhibition of Estrogen-Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry. Journal of Agricultural and Food Chemistry 60:22, pages 5547-5555.
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Chandrashekaran Girish, Vishnu Raj, Jayasree Arya & Sadasivam Balakrishnan. (2012) Evidence for the involvement of the monoaminergic system, but not the opioid system in the antidepressant-like activity of ellagic acid in mice. European Journal of Pharmacology 682:1-3, pages 118-125.
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J.M. Landete. (2011) Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health. Food Research International 44:5, pages 1150-1160.
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Rocío González-Barrio, Pilar Truchado, Hideyuki Ito, Juan C. Espín & Francisco A. Tomás-Barberán. (2011) UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals. Journal of Agricultural and Food Chemistry 59:4, pages 1152-1162.
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Mar Larrosa, María T. García-Conesa, Juan C. Espín & Francisco A. Tomás-Barberán. (2010) Ellagitannins, ellagic acid and vascular health. Molecular Aspects of Medicine 31:6, pages 513-539.
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Marcia da Silva Pinto, Joao Ernesto de Carvalho, Franco Maria Lajolo, Maria Inés Genovese & Kalidas Shetty. (2010) Evaluation of Antiproliferative, Anti-Type 2 Diabetes, and Antihypertension Potentials of Ellagitannins from Strawberries ( Fragaria  ×  ananassa Duch.) Using In Vitro Models . Journal of Medicinal Food 13:5, pages 1027-1035.
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Stephanie Corbett, Janice Daniel, Rachael Drayton, Melanie Field, Rebecca Steinhardt & Normalynn Garrett. (2010) Evaluation of the Anti-inflammatory Effects of Ellagic Acid. Journal of PeriAnesthesia Nursing 25:4, pages 214-220.
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Alexander C Whitley, Douglas H Sweet & Thomas Walle. (2006) Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract. Journal of Pharmacy and Pharmacology 58:9, pages 1201-1209.
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M. Cuccioloni, M. Mozzicafreddo, L. Sparapani, M. Spina, A.M. Eleuteri, E. Fioretti & M. Angeletti. (2009) Pomegranate fruit components modulate human thrombin. Fitoterapia 80:5, pages 301-305.
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Patrice Njomnang Soh, Benoît Witkowski, David Olagnier, Marie-Laure Nicolau, Maria-Concepcion Garcia-Alvarez, Antoine Berry & Françoise Benoit-Vical. (2009) In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment. Antimicrobial Agents and Chemotherapy 53:3, pages 1100-1106.
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Heather A. Ross, Gordon J. McDougall & Derek Stewart. (2007) Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts. Phytochemistry 68:2, pages 218-228.
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D. Venkat Ratnam, D.D. Ankola, V. Bhardwaj, D.K. Sahana & M.N.V. Ravi Kumar. (2006) Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. Journal of Controlled Release 113:3, pages 189-207.
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Alexander C Whitley, Douglas H. Sweet & Thomas Walle. (2005) THE DIETARY POLYPHENOL ELLAGIC ACID IS A POTENT INHIBITOR OF hOAT1. Drug Metabolism and Disposition 33:8, pages 1097-1100.
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Navindra P. Seeram, Rupo Lee & David Heber. (2004) Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta 348:1-2, pages 63-68.
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Fan Lei, Dong-Ming Xing, Lan Xiang, Yu-Nan Zhao, Wei Wang, Lu-Jun Zhang & Li-Jun Du. (2003) Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. Journal of Chromatography B 796:1, pages 189-194.
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Alexander C Whitley, Gary D Stoner, Michael V Darby & Thomas Walle. (2003) Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid—extensive binding to protein and DNA. Biochemical Pharmacology 66:6, pages 907-915.
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Susanne U. Mertens-Talcott, Stephen T. Talcott & Susan S. Percival. (2003) Low Concentrations of Quercetin and Ellagic Acid Synergistically Influence Proliferation, Cytotoxicity and Apoptosis in MOLT-4 Human Leukemia Cells–. The Journal of Nutrition 133:8, pages 2669-2674.
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Michael N Clifford & Augustin Scalbert. (2000) Ellagitannins - nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture 80:7, pages 1118-1125.
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Gary D. Stoner & Hasan Mukhtar. (1995) Polyphenols as cancer chemopreventive agents. Journal of Cellular Biochemistry 59:S22, pages 169-180.
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Anthony A. Frank, John M. Collier, Carol S. Forsyth, Young‐Hun Heur & Gary D. Stoner. (2005) Ellagic acid protects rat embryos in culture from the embryotoxic effects of N‐methyl‐N‐nitrosourea. Teratology 46:2, pages 109-115.
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Wenguang Zeng, Young-Hun Heur, Thomas H. Kinstle & Gary D. Stoner. (1991) Synthesis of [14CO]ellagic acid. Journal of Labelled Compounds and Radiopharmaceuticals 29:6, pages 657-666.
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Hans F. Stich. (1991) The beneficial and hazardous effects of simple phenolic compounds. Mutation Research/Genetic Toxicology 259:3-4, pages 307-324.
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