Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
137
Views
82
CrossRef citations to date
0
Altmetric
Original Article

Studies on the metabolism and excretion of benzyl isothiocyanate in man

, , , &
Pages 441-447 | Received 07 Aug 1987, Accepted 04 Nov 1987, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Evelyn Lamy, Cathy Scholtes, Corinna Herz & Volker Mersch-Sundermann. (2011) Pharmacokinetics and pharmacodynamics of isothiocyanates. Drug Metabolism Reviews 43:3, pages 387-407.
Read now
Rex Munday, Yuesheng Zhang, Jed W. Fahey, Hillary E. Jobson, Christine M. Munday, Jun Li & Katherine K. Stephenson. (2006) Evaluation of Isothiocyanates as Potent Inducers of Carcinogen-Detoxifying Enzymes in the Urinary Bladder: Critical Nature of In Vivo Bioassay. Nutrition and Cancer 54:2, pages 223-231.
Read now
Franca Bianchini & Harri Vainio. (2004) Isothiocyanates in Cancer Prevention. Drug Metabolism Reviews 36:3-4, pages 655-667.
Read now
C. Clifford Conaway, Serkadis M. Getahun, Leonard L. Liebes, Donald J. Pusateri, Debra K. W. Topham, María Botero-Omary & Fung-Lung Chung. (2000) Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli. Nutrition and Cancer 38:2, pages 168-178.
Read now

Articles from other publishers (78)

Anna E. Kaiser, Mojdeh Baniasadi, Derrek Giansiracusa, Matthew Giansiracusa, Michael Garcia, Zachary Fryda, Tin Lok Wong & Anupam Bishayee. (2021) Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential. Cancers 13:19, pages 4796.
Crossref
Modhi O. Alotaibi, Galal Khamis, Hamada AbdElgawad, Afrah E. Mohammed, Mohamed S. Sheteiwy, Mudawi M. Elobeid & Ahmed M. Saleh. (2021) Lepidium sativum Sprouts Grown under Elevated CO2 Hyperaccumulate Glucosinolates and Antioxidants and Exhibit Enhanced Biological and Reduced Antinutritional Properties. Biomolecules 11:8, pages 1174.
Crossref
Eun Suk Son, Xiang Fei, Jin-Ha Yoon, Seung-Yong Seo, Han-Joo Maeng, Sung Hwan Jeong & Yu Chul Kim. (2021) Comparison of Pharmacokinetics and Anti-Pulmonary Fibrosis-Related Effects of Sulforaphane and Sulforaphane N-acetylcysteine. Pharmaceutics 13:7, pages 958.
Crossref
Montserrat Esteve. (2020) Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome. Frontiers in Nutrition 7.
Crossref
Hsin‐Bai Yin, Ashley Boomer, Chi‐Hung Chen & Jitendra Patel. (2020) Efficacy of benzyl isothiocyanate for controlling Salmonella on alfalfa seeds and sprouts . International Journal of Food Science & Technology 55:6, pages 2669-2676.
Crossref
Abdelaziz Bouhadiba, Seyfeddine Rahali, Youghourta Belhocine, Hamza Allal, Leila Nouar & Mohamed Rahim. (2020) Structural and energetic investigation on the host/guest inclusion process of benzyl isothiocyanate into β-cyclodextrin using dispersion-corrected DFT calculations. Carbohydrate Research 491, pages 107980.
Crossref
Luigi Mandrich & Emilia Caputo. (2020) Brassicaceae-Derived Anticancer Agents: Towards a Green Approach to Beat Cancer. Nutrients 12:3, pages 868.
Crossref
Luis Nestor Apaza Ticona, Victor Tena Pérez & Paulina Bermejo Benito. (2020) Local/traditional uses, secondary metabolites and biological activities of Mashua (Tropaeolum tuberosum Ruíz & Pavón). Journal of Ethnopharmacology 247, pages 112152.
Crossref
Maged S. Abdel-Kader, Prawez Alam, Y.T. Kamal, Khalid M. Alkharfy, Ahmed I. Foudah & Saleh I. Alqasoumi. (2019) Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”. Saudi Pharmaceutical Journal 27:6, pages 753-755.
Crossref
Maged S. Abdel-Kader, Khalid S. Al Shahrani, Mohammed H. Alqarni, Mohammed A. Salkini, Elsadig H. Khamis, Hazem A. Ghabbour & Saleh I. Alqasoumi. (2019) Effect of hydroxylated solvents on the active constituents of Salvadora persica root “Siwak”. Saudi Pharmaceutical Journal 27:2, pages 220-224.
Crossref
Carla Kühn, Franziska Kupke, Susanne Baldermann, Rebecca Klopsch, Evelyn Lamy, Silke Hornemann, Andreas F. H. Pfeiffer, Monika Schreiner, Franziska S. Hanschen & Sascha Rohn. (2018) Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium ( Tropaeolum majus L.)—A Pilot Study . Molecular Nutrition & Food Research 62:20.
Crossref
Shivani Uppal, Khushwinder Kaur, Rajendra Kumar, Naval Deep Kaur, Geeta Shukla & S.K. Mehta. (2018) Chitosan nanoparticles as a biocompatible and efficient nanowagon for benzyl isothiocyanate. International Journal of Biological Macromolecules 115, pages 18-28.
Crossref
Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
Crossref
Maged Saad Abdel-Kader, Elsadig Hassan Khamis, Ahmed Ibrahim Foudah & Mohammed Hamed Alqarni. (2018) GC quantitative analysis of benzyl isothiocyanate in Salvadora persica roots extract and dental care herbal products. Saudi Pharmaceutical Journal 26:4, pages 462-466.
Crossref
Shivani Uppal, Khushwinder Kaur, Rajendra Kumar, Nakshdeep Kaur Kahlon, Rachna Singh & S.K. Mehta. (2017) Encompassment of Benzyl Isothiocyanate in cyclodextrin using ultrasonication methodology to enhance its stability for biological applications. Ultrasonics Sonochemistry 39, pages 25-33.
Crossref
Andrew Leone, Gregory Diorio, Wade Sexton, Michael Schell, Mark Alexandrow, Jed W. Fahey & Nagi B. Kumar. (2017) Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach. Oncotarget 8:21, pages 35412-35424.
Crossref
R. Recio, E. Vengut-Climent, L.G. Borrego, N. Khiar & I. Fernández. 2017. 167 242 .
Rohit Arora, Sakshi Bhushan & Saroj Arora. 2017. Glucosinolates. Glucosinolates 383 405 .
Stefanie Platz, Carla Kühn, Sonja Schiess, Monika Schreiner, Margrit Kemper, Olga Pivovarova, Andreas F. H. Pfeiffer & Sascha Rohn. (2016) Bioavailability and metabolism of benzyl glucosinolate in humans consuming Indian cress ( Tropaeolum majus L.) . Molecular Nutrition & Food Research 60:3, pages 652-660.
Crossref
Rohit Arora, Sakshi Bhushan & Saroj Arora. 2016. Glucosinolates. Glucosinolates 1 23 .
Omkara L. Veeranki, Arup Bhattacharya, Li Tang, James R. Marshall & Yuesheng Zhang. (2015) Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer. Current Pharmacology Reports 1:4, pages 272-282.
Crossref
Andrew D. Gloss, Daniel G. Vassão, Alexander L. Hailey, Anna C. Nelson Dittrich, Katharina Schramm, Michael Reichelt, Timothy J. Rast, Andrzej Weichsel, Matthew G. Cravens, Jonathan Gershenzon, William R. Montfort & Noah K. Whiteman. (2014) Evolution in an Ancient Detoxification Pathway Is Coupled with a Transition to Herbivory in the Drosophilidae. Molecular Biology and Evolution 31:9, pages 2441-2456.
Crossref
Teresa Oliviero, Ruud Verkerk, Martijn Vermeulen & Matthijs Dekker. (2014) In vivo formation and bioavailability of isothiocyanates from glucosinolates in broccoli as affected by processing conditions. Molecular Nutrition & Food Research 58:7, pages 1447-1456.
Crossref
Stefanie Platz, Carla Kühn, Sonja Schiess, Monika Schreiner, Inga Mewis, Margrit Kemper, Andreas Pfeiffer & Sascha Rohn. (2013) Determination of benzyl isothiocyanate metabolites in human plasma and urine by LC-ESI-MS/MS after ingestion of nasturtium (Tropaeolum majus L.). Analytical and Bioanalytical Chemistry 405:23, pages 7427-7436.
Crossref
Chinthalapally V. Rao. (2013) Benzyl Isothiocyanate: Double Trouble for Breast Cancer Cells. Cancer Prevention Research 6:8, pages 760-763.
Crossref
Ginés B. Martínez-Hernández, Perla A. Gómez, Noelia V. García-Talavera, Francisco Artés-Hernández, Tamara Monedero-Saiz, Carmen Sánchez-Álvarez & Francisco Artés. (2013) Human metabolic fate of glucosinolates from kailan-hybrid broccoli. Differences between raw and microwaved consumption. Food Research International 53:1, pages 403-408.
Crossref
Melinda-Rita Márton, Angelika Krumbein, Stefanie Platz, Monika Schreiner, Sascha Rohn, Andreas Rehmers, Vasile Lavric, Volker Mersch-Sundermann & Evelyn Lamy. (2013) Determination of bioactive, free isothiocyanates from a glucosinolate-containing phytotherapeutic agent: A pilot study with in vitro models and human intervention. Fitoterapia 85, pages 25-34.
Crossref
Monika Okulicz & Iwona Hertig. (2012) Benzyl isothiocyanate disturbs lipid metabolism in rats in a way independent of its thyroid impact following in vivo long-term treatment and in vitro adipocytes studies. Journal of Physiology and Biochemistry 69:1, pages 75-84.
Crossref
Y. Zhang. (2011) The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates. Carcinogenesis 33:1, pages 2-9.
Crossref
Hussaini Syed Sha Qhattal, Shu Wang, Tri Salihima, Sanjay K. Srivastava & Xinli Liu. (2011) Nanoemulsions of Cancer Chemopreventive Agent Benzyl Isothiocyanate Display Enhanced Solubility, Dissolution, and Permeability. Journal of Agricultural and Food Chemistry 59:23, pages 12396-12404.
Crossref
Ugir Hossain Sk, A.S. Prakasha Gowda, Melissa A. Crampsie, Jong K. Yun, Thomas E. Spratt, Shantu Amin & Arun K. Sharma. (2011) Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics. European Journal of Medicinal Chemistry 46:8, pages 3331-3338.
Crossref
Breeze E. Cavell, Sharifah S. Syed Alwi, Alison Donlevy & Graham Packham. (2011) Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human health. Biochemical Pharmacology 81:3, pages 327-336.
Crossref
Juana Frias, Piotr Gulewicz, Cristina Martinez-Villaluenga, Elena Peñas, Mariusz K. Piskula, Halina Kozlowska, Ewa Ciska, Krzysztof Gulewicz & Concepción Vidal-Valverde. (2010) Changes in Nutritional Value and Cytotoxicity of Garden Cress Germinated with Different Selenium Solutions. Journal of Agricultural and Food Chemistry 58:4, pages 2331-2336.
Crossref
Adarsh Pal Vig, Geetanjali Rampal, Tarunpreet Singh Thind & Saroj Arora. (2009) Bio-protective effects of glucosinolates – A review. LWT - Food Science and Technology 42:10, pages 1561-1572.
Crossref
Ruud Verkerk, Monika Schreiner, Angelika Krumbein, Ewa Ciska, Birgit Holst, Ian Rowland, Remi De Schrijver, Magnor Hansen, Clarissa Gerhäuser, Richard Mithen & Matthijs Dekker. (2009) Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health. Molecular Nutrition & Food Research 53:S2, pages S219-S219.
Crossref
M. Mari, F. Neri & P. Bertolini. 2010. Post-harvest Pathology. Post-harvest Pathology 119 135 .
Arun K. Sharma, Arati Sharma, Dhimant Desai, SubbaRao V. Madhunapantula, Sung Jin Huh, Gavin P. Robertson & Shantu Amin. (2008) Synthesis and Anticancer Activity Comparison of Phenylalkyl Isoselenocyanates with Corresponding Naturally Occurring and Synthetic Isothiocyanates. Journal of Medicinal Chemistry 51:24, pages 7820-7826.
Crossref
Maik Kleinwächter, Ewald Schnug & Dirk Selmar. (2008) The Glucosinolate−Myrosinase System in Nasturtium ( Tropaeolum majus L.): Variability of Biochemical Parameters and Screening for Clones Feasible for Pharmaceutical Utilization . Journal of Agricultural and Food Chemistry 56:23, pages 11165-11170.
Crossref
Martijn Vermeulen, Ineke W. A. A. Klöpping-Ketelaars, Robin van den Berg & Wouter H. J. Vaes. (2008) Bioavailability and Kinetics of Sulforaphane in Humans after Consumption of Cooked versus Raw Broccoli. Journal of Agricultural and Food Chemistry 56:22, pages 10505-10509.
Crossref
Li Tang, Gary R. Zirpoli, Khurshid Guru, Kirsten B. Moysich, Yuesheng Zhang, Christine B. Ambrosone & Susan E. McCann. (2008) Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention 17:4, pages 938-944.
Crossref
M. Mari, O. Leoni, R. Bernardi, F. Neri & S. Palmieri. (2008) Control of brown rot on stonefruit by synthetic and glucosinolate-derived isothiocyanates. Postharvest Biology and Technology 47:1, pages 61-67.
Crossref
Akira Murakami & Hajime Ohigashi. (2007) Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. International Journal of Cancer 121:11, pages 2357-2363.
Crossref
Mette Kristensen, Kirstine S. Krogholm, Hanne Frederiksen, Fritz Duus, Claus Cornett, Susanne H. Bügel & Salka E. Rasmussen. (2007) Improved synthesis methods of standards used for quantitative determination of total isothiocyanates from broccoli in human urine. Journal of Chromatography B 852:1-2, pages 229-234.
Crossref
Vanessa Rungapamestry, Alan J. Duncan, Zoë Fuller & Brian Ratcliffe. (2007) Effect of cooking brassica vegetables on the subsequent hydrolysis and metabolic fate of glucosinolates. Proceedings of the Nutrition Society 66:1, pages 69-81.
Crossref
Jennifer L. Donovan, Claudine Manach, Richard M. Faulks & Paul A. Kroon. 2006. Plant Secondary Metabolites. Plant Secondary Metabolites 303 351 .
Richard Mithen. 2006. Plant Secondary Metabolites. Plant Secondary Metabolites 25 46 .
Martijn Vermeulen, Robin van den Berg, Andreas P. Freidig, Peter J. van Bladeren & Wouter H. J. Vaes. (2006) Association between Consumption of Cruciferous Vegetables and Condiments and Excretion in Urine of Isothiocyanate Mercapturic Acids. Journal of Agricultural and Food Chemistry 54:15, pages 5350-5358.
Crossref
Li Tang, Guolin Li, Liguo Song & Yuesheng Zhang. (2006) The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anti-Cancer Drugs 17:3, pages 297-305.
Crossref
Yang-Ming Yang, Meena Jhanwar-Uniyal, Joel Schwartz, C. Clifford Conaway, H. Dorota Halicka, Frank Traganos & Fung-Lung Chung. (2005) N -Acetylcysteine Conjugate of Phenethyl Isothiocyanate Enhances Apoptosis in Growth-Stimulated Human Lung Cells . Cancer Research 65:18, pages 8538-8547.
Crossref
Li Tang & Yuesheng Zhang. (2005) Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Molecular Cancer Therapeutics 4:8, pages 1250-1259.
Crossref
R. Troncoso, C. Espinoza, A. Sánchez-Estrada, M.E. Tiznado & Hugo S. García. (2005) Analysis of the isothiocyanates present in cabbage leaves extract and their potential application to control Alternaria rot in bell peppers. Food Research International 38:6, pages 701-708.
Crossref
R Troncoso‐Rojas, A Sánchez‐Estrada, C Ruelas, Hugo S García & ME Tiznado‐Hernández. (2005) Effect of benzyl isothiocyanate on tomato fruit infection development by Alternaria alternata . Journal of the Science of Food and Agriculture 85:9, pages 1427-1434.
Crossref
Tamaro S. Hudson, Gary D. Stoner, Mark A. Morse, Heather Young & Susan R. Mallery. (2005) Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. Toxicology Letters 155:3, pages 427-436.
Crossref
Yuesheng Zhang. (2004) Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 555:1-2, pages 173-190.
Crossref
Li Tang & Yuesheng Zhang. (2004) Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells. The Journal of Nutrition 134:8, pages 2004-2010.
Crossref
Yuesheng Zhang. 2004. Phytochemicals in Health and Disease. Phytochemicals in Health and Disease 121 141 .
A. Adebiyi, P.G. Adaikan & R.N.V. Prasad. (2004) Pregnancy outcomes following pre- and post-implantation exposure of Sprague–Dawley rats to benzyl isothiocyanate. Food and Chemical Toxicology 42:5, pages 715-720.
Crossref
Eileen C Callaway, Yuesheng Zhang, Wade Chew & H.-H.Sherry Chow. (2004) Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates. Cancer Letters 204:1, pages 23-31.
Crossref
Stephen S. Hecht. 2004. Cancer Chemoprevention. Cancer Chemoprevention 21 35 .
Thomas W. Kensler & Paul Talalay. 2004. Cancer Chemoprevention. Cancer Chemoprevention 3 20 .
E.-S Hwang & E.H Jeffery. (2003) Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts. Food and Chemical Toxicology 41:12, pages 1817-1825.
Crossref
Martijn Vermeulen, Binne Zwanenburg, Gordon J.F Chittenden & Hans Verhagen. (2003) Synthesis of isothiocyanate-derived mercapturic acids. European Journal of Medicinal Chemistry 38:7-8, pages 729-737.
Crossref
Keisuke Akagi, Masashi Sano, Kumiko Ogawa, Masao HiroseHideo Goshima & Tomoyuki Shirai. (2016) Involvement of Toxicity as an Early Event in Urinary Bladder Carcinogenesis Induced by Phenethyl Isothiocyanate, Benzyl Isothiocyanate, and Analogues in F344 Rats. Toxicologic Pathology 31:4, pages 388-396.
Crossref
Martijn Vermeulen, Hans J. M. van Rooijen & Wouter H. J. Vaes. (2003) Analysis of Isothiocyanate Mercapturic Acids in Urine:  A Biomarker for Cruciferous Vegetable Intake. Journal of Agricultural and Food Chemistry 51:12, pages 3554-3559.
Crossref
Cyrille Krul, Christèle Humblot, Catherine Philippe, Martijn Vermeulen, Marleen van Nuenen, Robert Havenaar & Sylvie Rabot. (2002) Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model. Carcinogenesis 23:6, pages 1009-1016.
Crossref
H. Crews, G. Alink, R. Andersen, V. Braesco, B. Holst, G. Maiani, L. Ovesen, M. Scotter, M. Solfrizzo, R. van den Berg, H. Verhagen & G. Williamson. (2007) A critical assessment of some biomarker approaches linked with dietary intake. British Journal of Nutrition 86:S1, pages S5-S35.
Crossref
Leonard Liebes, C.Clifford Conaway, Howard Hochster, Sandra Mendoza, Stephen S. Hecht, James Crowell & Fung-Lung Chung. (2001) High-Performance Liquid Chromatography-Based Determination of Total Isothiocyanate Levels in Human Plasma: Application to Studies with 2-Phenethyl Isothiocyanate. Analytical Biochemistry 291:2, pages 279-289.
Crossref
Richard F Mithen. 2001. 213 262 .
Yuesheng Zhang. (2000) Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis 21:6, pages 1175-1182.
Crossref
Richard F Mithen, Matthijs Dekker, Ruud Verkerk, Sylvie Rabot & Ian T Johnson. (2000) The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods. Journal of the Science of Food and Agriculture 80:7, pages 967-984.
Crossref
T.J. Smith & C.S. Yang. (2000) Effect of Organosulfur Compounds from Garlic and Cruciferous Vegetables on Drug Metabolism Enzymes. Drug Metabolism and Drug Interactions 17:1-4.
Crossref
Harshadrai M. Rawel, Jürgen Kroll, Brigitte Riese-Schneider & Sophie Haebel. (1998) Physicochemical and Enzymatic Properties of Benzyl Isothiocyanate Derivatized Proteinases. Journal of Agricultural and Food Chemistry 46:12, pages 5043-5051.
Crossref
Ding Jiao, Mimi C. Yu, Jean H. Hankin, Siew-Hong Low & Fung-Lung Chung. (1998) Total Isothiocyanate Contents in Cooked Vegetables Frequently Consumed in Singapore. Journal of Agricultural and Food Chemistry 46:3, pages 1055-1058.
Crossref
Paul D. Brown & Matthew J. Morra. 1997. 167 231 .
Fung-Lung Chung, Ding Jiao, C. Clifford Conaway, Theresa J. Smith, Chung S. Yang & Mimi C. Yu. (1997) Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates. Journal of Cellular Biochemistry 67:S27, pages 76-85.
Crossref
S.R.R. Musk, S.B. Astley, S.M. Edwards, P. Stephenson, R.B. Hubert & I.T. Johnson. (1995) Cytotoxic and clastogenic effects of benzyl isothiocyanate towards cultured mammalian cells. Food and Chemical Toxicology 33:1, pages 31-37.
Crossref
Thomas A. Baillie & Kelem Kassahun. 1994. 163 181 .
Thomas A. Baillie & J. Greg Slatter. (2002) Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo. Accounts of Chemical Research 24:9, pages 264-270.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.